fluoroquinolone antibiotic [Drug Class]

Accession ARO:0000001
Synonym(s)fluoroquinolone quinolone
DefinitionThe fluoroquinolones are a family of synthetic broad-spectrum antibiotics that are 4-quinolone-3-carboxylates. These compounds interact with topoisomerase II (DNA gyrase) to disrupt bacterial DNA replication, damage DNA, and cause cell death.
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
70 ontology terms | Show
+ enoxacin [Antibiotic]
+ ciprofloxacin [Antibiotic]
+ levofloxacin [Antibiotic]
+ moxifloxacin [Antibiotic]
+ gatifloxacin [Antibiotic]
+ lomefloxacin [Antibiotic]
+ nalidixic acid [Antibiotic]
+ norfloxacin [Antibiotic]
+ ofloxacin [Antibiotic]
+ trovafloxacin [Antibiotic]
+ grepafloxacin [Antibiotic]
+ sparfloxacin [Antibiotic]
+ pefloxacin [Antibiotic]
+ Tosufloxacin [Antibiotic]
+ sitafloxacin [Antibiotic]
+ cinoxacin [Antibiotic]
+ clinafloxacin [Antibiotic]
+ Clofazimine [Antibiotic]
+ fleroxacin [Antibiotic]
+ balofloxacin [Antibiotic]
+ delafloxacin [Antibiotic]
+ Zabofloxacin [Antibiotic]
+ Finefloxacin [Antibiotic]
+ Nemonoxacin [Antibiotic]
+ determinant of fluoroquinolone resistance confers_resistance_to_drug_class
+ Mycoplasma genitalium parC mutations confers resistance to Moxifloxacin confers_resistance_to_drug_class
+ fluoroquinolone resistant gyrB [AMR Gene Family] confers_resistance_to_drug_class
+ fluoroquinolone resistant parC [AMR Gene Family] confers_resistance_to_drug_class
+ fluoroquinolone resistant gyrA [AMR Gene Family] confers_resistance_to_drug_class
+ fluoroquinolone resistant parE [AMR Gene Family] confers_resistance_to_drug_class
+ MexAB-OprM confers_resistance_to_drug_class
+ MexCD-OprJ confers_resistance_to_drug_class
+ MexEF-OprN confers_resistance_to_drug_class
+ MexXY-OprM confers_resistance_to_drug_class
+ Mycoplasma genitalium 23S rRNA mutations confers resistance to fluoroquinolone and macrolide antibiotics confers_resistance_to_drug_class
+ oqxAB confers_resistance_to_drug_class
+ efmA confers_resistance_to_drug_class
+ lfrA confers_resistance_to_drug_class
+ Acinetobacter baumannii AbaQ confers_resistance_to_drug_class
+ MdtK confers_resistance_to_drug_class
+ AdeFGH confers_resistance_to_drug_class
+ AcrAB-TolC confers_resistance_to_drug_class
+ AcrEF-TolC confers_resistance_to_drug_class
+ AdeIJK confers_resistance_to_drug_class
+ CmeABC confers_resistance_to_drug_class
+ blt confers_resistance_to_drug_class
+ bmr confers_resistance_to_drug_class
+ CeoAB-OpcM confers_resistance_to_drug_class
+ MexVW-OprM confers_resistance_to_drug_class
+ SmeDEF confers_resistance_to_drug_class
+ quinolone resistance protein (qnr) [AMR Gene Family] confers_resistance_to_drug_class
+ qacH confers_resistance_to_drug_class
+ qacB confers_resistance_to_drug_class
+ qacA confers_resistance_to_drug_class
+ cdeA confers_resistance_to_drug_class
+ AxyXY-OprZ confers_resistance_to_drug_class
+ Sugar Porin (SP) [AMR Gene Family] confers_resistance_to_drug_class
+ MipA-interacting Protein [AMR Gene Family] confers_resistance_to_drug_class
+ abeM confers_resistance_to_drug_class
+ TLA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ fluoroquinolone self resistant parC [AMR Gene Family] confers_resistance_to_drug_class
+ ciprofloxacin phosphotransferase [AMR Gene Family] confers_resistance_to_drug_class
+ Mycoplasma genitalium gyrA mutation confers resistance to fluoroquinolones confers_resistance_to_drug_class
+ QepA4 confers_resistance_to_drug_class
+ QepA3 confers_resistance_to_drug_class
+ PmpM confers_resistance_to_drug_class
+ LAP beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ fluoroquinolone sensitive gyrA targeted_by
+ fluoroquinolone sensitive gyrB targeted_by
+ fluoroquinolone sensitive parC targeted_by
Publications

Nix DE, et al. 1987. Clin Pharm 6(2):105-17 Ciprofloxacin and norfloxacin, two fluoroquinolone antimicrobials. (PMID 3311572)

Barry AL, et al. 1987. Diagn. Microbiol. Infect. Dis. 6(1):77-9 Resistance to ten different fluoroquinolone antibiotics following in vitro exposures to nalidixic acid. (PMID 3802748)

Nesar S, et al. 2012. Pak J Pharm Sci 25(4):877-81 Emergence of resistance to fluoroquinolones among gram positive and gram negative clinical isolates. (PMID 23010009)