fluoroquinolone sensitive gyrA

Accession ARO:3000733
Synonym(s)gyrase A
DefinitionDNA gyrase is responsible for DNA supercoiling and consists of two alpha and two beta subunits. Binding the alpha-subunit is sufficient to inhibit DNA supercoiling.
Drug Classfluoroquinolone antibiotic
Classification4 ontology terms | Show
Parent Term(s)19 ontology terms | Show
+ targeted_by fluoroquinolone antibiotic [Drug Class]
+ targeted_by_antibiotic ciprofloxacin [Antibiotic]
+ targeted_by_antibiotic enoxacin [Antibiotic]
+ targeted_by_antibiotic gatifloxacin [Antibiotic]
+ targeted_by_antibiotic grepafloxacin [Antibiotic]
+ targeted_by_antibiotic levofloxacin [Antibiotic]
+ targeted_by_antibiotic lomefloxacin [Antibiotic]
+ targeted_by_antibiotic moxifloxacin [Antibiotic]
+ targeted_by_antibiotic nalidixic acid [Antibiotic]
+ targeted_by_antibiotic norfloxacin [Antibiotic]
+ targeted_by_antibiotic ofloxacin [Antibiotic]
+ targeted_by_antibiotic pefloxacin [Antibiotic]
+ targeted_by_antibiotic sparfloxacin [Antibiotic]
+ targeted_by_antibiotic trovafloxacin [Antibiotic]
+ antibiotic sensitive DNA topoisomerase subunit gyrA
+ targeted_by_antibiotic cinoxacin [Antibiotic]
+ targeted_by_antibiotic clinafloxacin [Antibiotic]
+ targeted_by_antibiotic clofazimine [Antibiotic]
+ targeted_by_antibiotic fleroxacin [Antibiotic]

Reece RJ and Maxwell A. 1991. Crit Rev Biochem Mol Biol 26(3-4): 335-375. DNA gyrase: structure and function. (PMID 1657531)

Drlica K and Zhao X. 1997. Microbiol Mol Biol Rev 61(3): 377-392. DNA gyrase, topoisomerase IV, and the 4-quinolones. (PMID 9293187)