clofazimine [Antibiotic]

Download Sequences


Accession ARO:3004012
Synonym(s)Lampren Lamprene
DefinitionClofazimine is a fluoroquinolone-class phenazine dye used for the treatment of leprosy. Clofazimine binds to DNA and disrupts bacterial DNA gyrase, thereby causing double-stranded DNA breaks, and subsequent cell death.
SMILESCC(C)/N=c1\cc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2cc1Nc1ccc(Cl)cc1
PubChem2794
ChEMBLCHEMBL1292
ChEBI3749
CAS2030-63-9
Drug Classfluoroquinolone antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
4 ontology terms | Show
Publications

Arbiser JL, et al. 1995. J. Am. Acad. Dermatol. 32(2 Pt 1):241-7 Clofazimine: a review of its medical uses and mechanisms of action. (PMID 7829710)

Curator Acknowledgements
Curator Description Most Recent Edit