Clofazimine [Antibiotic]

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Accession ARO:3004012
Synonym(s)Lamprene Lampren
DefinitionClofazimine is a fluoroquinolone-class phenazine dye used for the treatment of leprosy. Clofazimine binds to DNA and disrupts bacterial DNA gyrase, thereby causing double-stranded DNA breaks, and subsequent cell death.
Drug Classfluoroquinolone antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
2 ontology terms | Show
+ fluoroquinolone sensitive gyrA targeted_by_antibiotic
+ fluoroquinolone sensitive gyrB targeted_by_antibiotic
Publications

Arbiser JL, et al. 1995. J. Am. Acad. Dermatol. 32(2 Pt 1):241-7 Clofazimine: a review of its medical uses and mechanisms of action. (PMID 7829710)