Accession | ARO:3004012 |
Synonym(s) | Lampren Lamprene |
Definition | Clofazimine is a fluoroquinolone-class phenazine dye used for the treatment of leprosy. Clofazimine binds to DNA and disrupts bacterial DNA gyrase, thereby causing double-stranded DNA breaks, and subsequent cell death. |
SMILES | CC(C)/N=c1\cc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2cc1Nc1ccc(Cl)cc1 |
PubChem | 2794 |
ChEMBL | CHEMBL1292 |
ChEBI | 3749 |
CAS | 2030-63-9 |
Drug Class | fluoroquinolone antibiotic |
Classification | 2 ontology terms | Show |
Parent Term(s) | 1 ontology terms | Show + fluoroquinolone antibiotic [Drug Class] |
Sub-Term(s) | 4 ontology terms | Show + fluoroquinolone sensitive gyrA targeted_by_antibiotic + fluoroquinolone sensitive gyrB targeted_by_antibiotic + Mycobacterium tuberculosis Rv2535c with mutation conferring resistance to bedaquiline confers_resistance_to_antibiotic + Mycobacterium tuberculosis Rv0678 with mutation conferring resistance to clofazimine confers_resistance_to_antibiotic |
Publications | Arbiser JL, et al. 1995. J. Am. Acad. Dermatol. 32(2 Pt 1):241-7 Clofazimine: a review of its medical uses and mechanisms of action. (PMID 7829710) |
Curator | Description | Most Recent Edit |
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