clinafloxacin [Antibiotic]

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Accession ARO:3004011
DefinitionClinafloxacin is a fluoroquinolone antibiotic and gyrase (DNA topoisomerase II) inhibitor. It binds to DNA gyrase and disrupts replication by causing double-stranded DNA breaks, resulting in cell death.
Drug Classfluoroquinolone antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
2 ontology terms | Show
+ fluoroquinolone sensitive gyrA targeted_by_antibiotic
+ fluoroquinolone sensitive gyrB targeted_by_antibiotic

Wise R, et al. 1988. Antimicrob. Agents Chemother. 32(8):1251-6 In vitro activity of PD 127,391, an enhanced-spectrum quinolone. (PMID 3142350)