ciprofloxacin [Antibiotic]

Download Sequences


Accession ARO:0000036
Synonym(s)CIP Ciproxan Ciprobay Cipro
DefinitionCiprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.
Drug Classfluoroquinolone antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
60 ontology terms | Show
+ fluoroquinolone sensitive parC targeted_by_antibiotic
+ fluoroquinolone sensitive gyrA targeted_by_antibiotic
+ fluoroquinolone sensitive gyrB targeted_by_antibiotic
+ norA confers_resistance_to_antibiotic
+ norB confers_resistance_to_antibiotic
+ pmrA confers_resistance_to_antibiotic
+ QepA1 confers_resistance_to_antibiotic
+ PatA-PatB confers_resistance_to_antibiotic
+ MexAB-OprM confers_resistance_to_antibiotic
+ quinolone resistance protein (qnr) [AMR Gene Family] confers_resistance_to_antibiotic
+ Bartonella bacilliformis gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Escherichia coli gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Mycobaterium leprae gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Staphylococcus aureus gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Morganella morganii gyrB conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Mycobacterium leprae gyrB conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Salmonella serovars gyrB conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Ureaplasma urealyticum gyrB conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Escherichia coli parC conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Mycoplasma hominis parC conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Staphylococcus aureus parC conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Streptococcus pneumoniae parC conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Ureaplasma urealyticum parC conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Escherichia coli parE conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Salmonella serovars parE conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Staphylococcus aureus parE conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Pseudomonas aeruginosa gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Campylobacter jejuni gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Acinetobacter baumannii gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Acinetobacter baumannii parC conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ mfd confers_resistance_to_antibiotic
+ Salmonella enterica gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Salmonella enterica parC conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ EfrAB confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnGH-TolC confers_resistance_to_antibiotic
+ MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin confers_resistance_to_antibiotic
+ MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam confers_resistance_to_antibiotic
+ MexEF-OprN with MexT mutation conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim confers_resistance_to_antibiotic
+ MexEF-OprN with MexS mutations conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim confers_resistance_to_antibiotic
+ Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime confers_resistance_to_antibiotic
+ MexAB-OprM with MexR mutations confers resistance to multiple antibiotics confers_resistance_to_antibiotic
+ AcrEF-TolC confers resistance to ciprofloxacin confers_resistance_to_antibiotic
+ MdtK confers_resistance_to_antibiotic
+ oqxAB confers_resistance_to_antibiotic
+ Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline confers_resistance_to_antibiotic
+ QepA2 confers_resistance_to_antibiotic
+ Serratia marcescens Omp1 confers_resistance_to_antibiotic
+ Escherichia coli LamB confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr confers_resistance_to_antibiotic
+ QnrS1 confers_resistance_to_antibiotic
+ MexXY-OprM confers_resistance_to_antibiotic
+ MexXY-OprA confers_resistance_to_antibiotic
+ MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics confers_resistance_to_antibiotic
+ MexAB-OprM with NalC mutations conferring resistance to aztreonam confers_resistance_to_antibiotic
+ abeM confers_resistance_to_antibiotic
+ hp1181 confers_resistance_to_antibiotic
+ CrpP confers_resistance_to_antibiotic
+ Staphylococcus aureus norA confers_resistance_to_antibiotic
+ hp1184 confers_resistance_to_antibiotic
Publications

Poole K. 2005. J Antimicrob Chemother 56(1): 20-51. Efflux-mediated antimicrobial resistance. (PMID 15914491)

Mitscher LA. 2005. Chem Rev 105(2): 559-592. Bacterial topoisomerase inhibitors: quinolone and pyridone antibacterial agents. (PMID 15700957)