ciprofloxacin [Antibiotic]

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Accession ARO:0000036
Synonym(s)CIP Cipro Ciprobay Ciproxan
DefinitionCiprofloxacin is a bacteriocidal fluoroquinolone. It blocks bacterial DNA replication by binding to the toposiomerase II or IV-DNA complex (or cleavable complex), thereby causing double-stranded breaks in the bacterial chromosome.
SMILESN/A
PubChem2764
Drug Classfluoroquinolone antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
197 ontology terms | Show
+ Fluoroquinolone sensitive parC targeted_by_antibiotic
+ fluoroquinolone sensitive gyrA targeted_by_antibiotic
+ fluoroquinolone sensitive gyrB targeted_by_antibiotic
+ norA confers_resistance_to_antibiotic
+ norB confers_resistance_to_antibiotic
+ pmrA confers_resistance_to_antibiotic
+ QepA1 confers_resistance_to_antibiotic
+ PatA-PatB confers_resistance_to_antibiotic
+ MexAB-OprM confers_resistance_to_antibiotic
+ quinolone resistance protein (qnr) [AMR Gene Family] confers_resistance_to_antibiotic
+ Bartonella bacilliformis gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Escherichia coli gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Mycobacterium leprae gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Staphylococcus aureus gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Morganella morganii gyrB conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Mycobacterium leprae gyrB conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Salmonella serovars gyrB conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Ureaplasma urealyticum gyrB conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Escherichia coli parC conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Mycoplasma hominis parC conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Staphylococcus aureus parC conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Streptococcus pneumoniae parC conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Ureaplasma urealyticum parC conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Escherichia coli parE conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Salmonella serovars parE conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Staphylococcus aureus parE conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Pseudomonas aeruginosa gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Campylobacter jejuni gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Acinetobacter baumannii gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Acinetobacter baumannii parC conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ mfd confers_resistance_to_antibiotic
+ Salmonella enterica gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Salmonella enterica parC conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ EfrAB confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnGH-TolC confers_resistance_to_antibiotic
+ MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin confers_resistance_to_antibiotic
+ MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam confers_resistance_to_antibiotic
+ MexEF-OprN with MexT mutation conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim confers_resistance_to_antibiotic
+ MexEF-OprN with MexS mutations conferring resistance to chloramphenicol, ciprofloxacin, and trimethoprim confers_resistance_to_antibiotic
+ MexAB-OprM with MexR mutations confers resistance to multiple antibiotics confers_resistance_to_antibiotic
+ AcrEF-TolC confers resistance to ciprofloxacin confers_resistance_to_antibiotic
+ MdtK confers_resistance_to_antibiotic
+ oqxAB confers_resistance_to_antibiotic
+ QepA2 confers_resistance_to_antibiotic
+ Serratia marcescens Omp1 confers_resistance_to_antibiotic
+ Escherichia coli LamB confers_resistance_to_antibiotic
+ QnrS1 confers_resistance_to_antibiotic
+ MexXY-OprM confers_resistance_to_antibiotic
+ MexXY-OprA confers_resistance_to_antibiotic
+ MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics confers_resistance_to_antibiotic
+ MexAB-OprM with NalC mutations conferring resistance to aztreonam confers_resistance_to_antibiotic
+ abeM confers_resistance_to_antibiotic
+ hp1181 confers_resistance_to_antibiotic
+ Staphylococcus aureus norA confers_resistance_to_antibiotic
+ hp1184 confers_resistance_to_antibiotic
+ Burkholderia dolosa gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Neisseria gonorrhoeae gyrA with mutations conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Neisseria gonorrhoeae parC conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ NDM-33 confers_resistance_to_antibiotic
+ mdeA confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr3 confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr4 confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr5 confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr6 confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr7 confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr8 confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr9 confers_resistance_to_antibiotic
+ Capnocytophaga gingivalis gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Clostridioides difficile gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Clostridioides difficile gyrB conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Cutibacterium acnes gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Haemophilus parainfluenzae gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Haemophilus parainfluenzae parC conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Pseudomonas aeruginosa gyrA and parC conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Pseudomonas aeruginosa parE conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ QnrA1 confers_resistance_to_antibiotic
+ QnrA2 confers_resistance_to_antibiotic
+ QnrA3 confers_resistance_to_antibiotic
+ QnrA4 confers_resistance_to_antibiotic
+ QnrA5 confers_resistance_to_antibiotic
+ QnrA6 confers_resistance_to_antibiotic
+ QnrA7 confers_resistance_to_antibiotic
+ QnrB1 confers_resistance_to_antibiotic
+ QnrB10 confers_resistance_to_antibiotic
+ QnrB11 confers_resistance_to_antibiotic
+ QnrB12 confers_resistance_to_antibiotic
+ QnrB13 confers_resistance_to_antibiotic
+ QnrB14 confers_resistance_to_antibiotic
+ QnrB15 confers_resistance_to_antibiotic
+ QnrB16 confers_resistance_to_antibiotic
+ QnrB17 confers_resistance_to_antibiotic
+ QnrB18 confers_resistance_to_antibiotic
+ QnrB19 confers_resistance_to_antibiotic
+ QnrB2 confers_resistance_to_antibiotic
+ QnrB20 confers_resistance_to_antibiotic
+ QnrB21 confers_resistance_to_antibiotic
+ QnrB22 confers_resistance_to_antibiotic
+ QnrB23 confers_resistance_to_antibiotic
+ QnrB24 confers_resistance_to_antibiotic
+ QnrB25 confers_resistance_to_antibiotic
+ QnrB26 confers_resistance_to_antibiotic
+ QnrB27 confers_resistance_to_antibiotic
+ QnrB28 confers_resistance_to_antibiotic
+ QnrB29 confers_resistance_to_antibiotic
+ QnrB3 confers_resistance_to_antibiotic
+ QnrB30 confers_resistance_to_antibiotic
+ QnrB31 confers_resistance_to_antibiotic
+ QnrB32 confers_resistance_to_antibiotic
+ QnrB33 confers_resistance_to_antibiotic
+ QnrB34 confers_resistance_to_antibiotic
+ QnrB35 confers_resistance_to_antibiotic
+ QnrB36 confers_resistance_to_antibiotic
+ QnrB37 confers_resistance_to_antibiotic
+ QnrB38 confers_resistance_to_antibiotic
+ QnrB4 confers_resistance_to_antibiotic
+ QnrB40 confers_resistance_to_antibiotic
+ QnrB41 confers_resistance_to_antibiotic
+ QnrB42 confers_resistance_to_antibiotic
+ QnrB43 confers_resistance_to_antibiotic
+ QnrB44 confers_resistance_to_antibiotic
+ QnrB45 confers_resistance_to_antibiotic
+ QnrB46 confers_resistance_to_antibiotic
+ QnrB47 confers_resistance_to_antibiotic
+ QnrB48 confers_resistance_to_antibiotic
+ QnrB49 confers_resistance_to_antibiotic
+ QnrB5 confers_resistance_to_antibiotic
+ QnrB50 confers_resistance_to_antibiotic
+ QnrB54 confers_resistance_to_antibiotic
+ QnrB55 confers_resistance_to_antibiotic
+ QnrB56 confers_resistance_to_antibiotic
+ QnrB57 confers_resistance_to_antibiotic
+ QnrB58 confers_resistance_to_antibiotic
+ QnrB59 confers_resistance_to_antibiotic
+ QnrB6 confers_resistance_to_antibiotic
+ QnrB60 confers_resistance_to_antibiotic
+ QnrB61 confers_resistance_to_antibiotic
+ QnrB62 confers_resistance_to_antibiotic
+ QnrB64 confers_resistance_to_antibiotic
+ QnrB65 confers_resistance_to_antibiotic
+ QnrB66 confers_resistance_to_antibiotic
+ QnrB67 confers_resistance_to_antibiotic
+ QnrB68 confers_resistance_to_antibiotic
+ QnrB69 confers_resistance_to_antibiotic
+ QnrB7 confers_resistance_to_antibiotic
+ QnrB70 confers_resistance_to_antibiotic
+ QnrB71 confers_resistance_to_antibiotic
+ QnrB72 confers_resistance_to_antibiotic
+ QnrB73 confers_resistance_to_antibiotic
+ QnrB74 confers_resistance_to_antibiotic
+ QnrB8 confers_resistance_to_antibiotic
+ QnrB9 confers_resistance_to_antibiotic
+ QnrC confers_resistance_to_antibiotic
+ QnrD1 confers_resistance_to_antibiotic
+ QnrD2 confers_resistance_to_antibiotic
+ QnrS10 confers_resistance_to_antibiotic
+ QnrS11 confers_resistance_to_antibiotic
+ QnrS12 confers_resistance_to_antibiotic
+ QnrS15 confers_resistance_to_antibiotic
+ QnrS2 confers_resistance_to_antibiotic
+ QnrS3 confers_resistance_to_antibiotic
+ QnrS4 confers_resistance_to_antibiotic
+ QnrS5 confers_resistance_to_antibiotic
+ QnrS6 confers_resistance_to_antibiotic
+ QnrS7 confers_resistance_to_antibiotic
+ QnrS8 confers_resistance_to_antibiotic
+ QnrS9 confers_resistance_to_antibiotic
+ QnrVC1 confers_resistance_to_antibiotic
+ QnrVC2 confers_resistance_to_antibiotic
+ QnrVC3 confers_resistance_to_antibiotic
+ QnrVC4 confers_resistance_to_antibiotic
+ QnrVC5 confers_resistance_to_antibiotic
+ QnrVC6 confers_resistance_to_antibiotic
+ QnrVC7 confers_resistance_to_antibiotic
+ qnrE1 confers_resistance_to_antibiotic
+ qnrE2 confers_resistance_to_antibiotic
+ mfpA confers_resistance_to_antibiotic
+ Escherichia coli soxR with mutation conferring antibiotic resistance confers_resistance_to_antibiotic
+ Escherichia coli soxS with mutation conferring antibiotic resistance confers_resistance_to_antibiotic
+ Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime confers_resistance_to_antibiotic
+ Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline confers_resistance_to_antibiotic
+ Enterobacter aerogenes acrR with mutation conferring multidrug antibiotic resistance confers_resistance_to_antibiotic
+ Salmonella serovars soxS with mutation conferring antibiotic resistance confers_resistance_to_antibiotic
+ Salmonella enterica soxR with mutation conferring antibiotic resistance confers_resistance_to_antibiotic
+ Salmonella enterica ramR mutants confers_resistance_to_antibiotic
+ AAC(6')-Ib-cr1 confers_resistance_to_antibiotic
+ fosA5 confers_resistance_to_antibiotic
+ Mycobacterium avium gyrA with mutation conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Klebsiella pneumoniae acrA confers_resistance_to_antibiotic
+ QepA3 confers_resistance_to_antibiotic
+ QepA4 confers_resistance_to_antibiotic
+ Shigella flexneri acrA confers_resistance_to_antibiotic
+ lfrA confers_resistance_to_antibiotic
+ Salmonella isangi gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Salmonella isangi gyrB conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ aac(6')-Ib-cr10 confers_resistance_to_antibiotic
+ aac(6')-Ib-cr11 confers_resistance_to_antibiotic
Publications

Poole K. 2005. J Antimicrob Chemother 56(1): 20-51. Efflux-mediated antimicrobial resistance. (PMID 15914491)

Mitscher LA. 2005. Chem Rev 105(2): 559-592. Bacterial topoisomerase inhibitors: quinolone and pyridone antibacterial agents. (PMID 15700957)
Curator Acknowledgements
Curator Description Most Recent Edit