Salmonella serovars parE conferring resistance to fluoroquinolones

Accession ARO:3003317
DefinitionPoint mutation in Salmonella serovars parE resulting in fluoroquinolones resistance
AMR Gene Familyfluoroquinolone resistant parE
Drug Classfluoroquinolone antibiotic
Resistance Mechanismantibiotic target alteration
Classification12 ontology terms | Show
Parent Term(s)14 ontology terms | Show
+ fluoroquinolone resistant parE [AMR Gene Family]
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic enoxacin [Antibiotic]
+ confers_resistance_to_antibiotic gatifloxacin [Antibiotic]
+ confers_resistance_to_antibiotic grepafloxacin [Antibiotic]
+ confers_resistance_to_antibiotic levofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic lomefloxacin [Antibiotic]
+ confers_resistance_to_antibiotic moxifloxacin [Antibiotic]
+ confers_resistance_to_antibiotic nalidixic acid [Antibiotic]
+ confers_resistance_to_antibiotic norfloxacin [Antibiotic]
+ confers_resistance_to_antibiotic ofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic pefloxacin [Antibiotic]
+ confers_resistance_to_antibiotic sparfloxacin [Antibiotic]
+ confers_resistance_to_antibiotic trovafloxacin [Antibiotic]
Publications

O'Regan E, et al. 2009. Antimicrob Agents Chemother 53(3): 1080-1087. Multiple regulatory pathways associated with high-level ciprofloxacin and multidrug resistance in Salmonella enterica serovar enteritidis: involvement of RamA and other global regulators. (PMID 19104017)

Resistomes

Prevalence of Salmonella serovars parE conferring resistance to fluoroquinolones among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein variant model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Escherichia coli0%0%0.11%
Show Perfect Only


Detection Models

Model Type: protein variant model

Model Definition: The protein variant model is an AMR detection model. Protein variant models are similar to protein homolog models - they detect the presence of a protein sequence based on its similarity to a curated reference sequence, but secondarily search submitted query sequences for curated sets of mutations shown clinically to confer resistance relative to wild-type. This model includes a protein reference sequence, a curated BLASTP cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of: single resistance variants, insertions, deletions, co-dependent resistance variants, nonsense SNPs, and/or frameshift mutations. Protein variant model matches to reference sequences are categorized on two criteria: strict and loose. A strict match has a BLASTP bitscore above the curated BLASTP cutoff value and contains at least one detected mutation from amongst the mapped resistance variants; a loose match has a BLASTP bitscore below the curated BLASTP cutoff value but still contains at least one detected mutation from amongst the mapped resistance variants. Regardless of BLASTP bitscore, if a sequence does not contain one of the mapped resistance variants, it is not considered a match and not detected by the protein variant model.

Legend:

  • discovered in clinical, agricultural, or environmental isolates
  • discovered via laboratory selection experiments


Bit-score Cut-off (blastP): 1000


>gb|AAL22055.1|-|Salmonella serovars parE conferring resistance to fluoroquinolones [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
MTQTYNADAIEVLTGLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILH
ADQSLEVIDDGRGMPVDIHPEEGVPAVELILCRLHAGGKFSNKNYQFSGGLHGVGISVVN
ALSKRVEVTVRRDGQVYNIAFENGEKVQDLQVVGTCGKRNTGTSVHFWPDESFFDSPRFS
VSRLMHVLKAKAVLCPGVEITFKDEVNNSEQRWCYQDGLNDYLGEAVNGLPTLPEKPFIG
NFNGETEAVDWALLWLPEGGELLTESYVNLIPTMQGGTHVNGLRQGLLDAMREFCEYRNI
LPRGVKLSAEDIWDRCAYVLSVKMQDPQFAGQTKERLSSRQCAAFVSGVVKDAFSLWLNQ
NVQAAEQLAEMAIASAQRRLRAAKKVVRKKLTSGPALPGKLADCTAQDLNRTELFLVEGD
SAGGSAKQARDREYQAIMPLKGKILNTWEVSSDEVLASQEVHDISVAIGIDPDSDDLSQL
RYGKICILADADSDGLHIATLLCALFVRHFRALVKNGHVYVALPPLYRIDLGKEVYYALT
EEEKAGVLEQLKRKKGKPNVQRFKGLGEMNPMQLRETTLDPNTRRLVQLTISDEDDQRTN
AMMDMLLAKKRSEDRRNWLQEKGDLADLDV



>gb|AE006468.2|-|3343969-3345861|Salmonella serovars parE conferring resistance to fluoroquinolones [Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]
ATGACGCAAACTTATAACGCTGATGCCATTGAGGTACTCACTGGGCTTGAGCCGGTACGCCGCCGCCCGGGGATGTACACCGATACGACC
CGCCCCAACCATTTGGGTCAGGAAGTGATTGATAATAGTGTGGATGAAGCACTGGCAGGTCACGCCAAACGCGTGGATGTCATTTTACAT
GCCGATCAATCGCTGGAAGTGATTGACGACGGACGCGGGATGCCGGTGGATATCCATCCGGAAGAGGGGGTTCCGGCGGTAGAACTGATC
CTCTGTCGGCTTCATGCCGGCGGTAAATTCTCCAATAAGAACTATCAGTTCTCTGGTGGTCTGCATGGGGTGGGGATTTCGGTAGTAAAT
GCCCTGTCAAAGCGCGTGGAAGTGACCGTGCGCCGCGACGGTCAGGTCTATAACATCGCGTTTGAAAACGGCGAAAAAGTGCAGGATTTG
CAGGTTGTCGGCACCTGCGGTAAACGTAATACTGGAACCAGCGTCCATTTCTGGCCGGACGAAAGTTTCTTCGACAGCCCGCGTTTTTCT
GTCTCTCGCTTAATGCACGTTCTGAAAGCAAAAGCGGTGCTGTGTCCCGGCGTGGAAATCACTTTTAAAGATGAAGTGAATAACAGCGAG
CAGCGCTGGTGCTACCAGGATGGTCTGAACGACTATCTGGGCGAAGCGGTAAACGGCCTGCCGACGCTGCCGGAAAAGCCGTTTATCGGT
AATTTTAACGGTGAAACGGAAGCGGTTGACTGGGCGCTATTGTGGCTGCCGGAAGGCGGCGAATTACTGACGGAAAGCTACGTCAACCTG
ATCCCGACCATGCAGGGGGGGACGCACGTCAACGGTCTGCGCCAGGGCCTGCTCGACGCGATGCGCGAATTTTGCGAATACCGCAATATT
CTGCCGCGCGGCGTCAAACTGTCGGCGGAAGATATCTGGGATCGCTGCGCTTATGTGCTTTCCGTGAAAATGCAGGACCCGCAATTTGCC
GGGCAGACCAAAGAGCGTCTGTCGTCGCGTCAATGTGCGGCATTTGTTTCCGGCGTGGTGAAAGATGCCTTCAGCCTGTGGCTGAACCAG
AACGTGCAGGCGGCGGAACAACTGGCAGAGATGGCGATTGCCAGCGCGCAGCGGCGACTGCGCGCCGCAAAAAAAGTGGTGCGCAAAAAG
CTCACCAGCGGCCCGGCGTTGCCGGGGAAACTGGCGGACTGTACCGCGCAGGATCTTAATCGGACCGAGCTGTTCCTTGTGGAAGGGGAT
TCGGCGGGCGGTTCCGCCAAGCAGGCGCGCGATCGCGAATATCAGGCGATCATGCCGCTCAAAGGTAAGATCCTTAACACCTGGGAGGTC
TCTTCCGATGAAGTGCTGGCCTCGCAAGAAGTGCATGATATTTCCGTGGCGATCGGTATCGATCCGGACAGCGACGATCTGAGTCAGCTG
CGCTACGGCAAGATCTGTATCCTGGCGGATGCGGACTCCGATGGTTTGCATATCGCTACTCTGCTTTGCGCGCTGTTTGTCAGACACTTC
CGCGCGCTGGTGAAGAATGGTCATGTCTACGTCGCGCTACCGCCGCTATACCGTATCGATTTGGGTAAAGAGGTCTATTACGCGCTGACG
GAAGAAGAGAAGGCGGGCGTACTGGAACAACTGAAGCGTAAGAAAGGCAAGCCGAACGTACAGCGTTTCAAAGGCCTGGGAGAAATGAAC
CCGATGCAGTTACGCGAAACCACGCTTGATCCGAATACTCGCCGCCTGGTGCAGCTCACCATTAGCGATGAAGACGATCAGCGTACTAAT
GCGATGATGGATATGCTGCTGGCGAAGAAACGTTCTGAAGATCGACGCAACTGGCTACAGGAAAAAGGCGATCTCGCGGATCTCGACGTG
TAA