moxifloxacin [Antibiotic]

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Accession ARO:0000074
Synonym(s)Avelox Actira (hydrochloride) Moxifloxacin hydrochloride MXFX Vigamox Avelox (hydrochloride)
DefinitionMoxifloxacin is a fourth generation synthetic fluoroquinolone chemotherapeutic agent, and has been shown to be significantly more active than levofloxacin (4 to 8 times more) against Streptococcus pneumoniae. It acts by inhibiting bacterial DNA topoisomerases.
Drug Classfluoroquinolone antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
24 ontology terms | Show
+ fluoroquinolone sensitive gyrA targeted_by_antibiotic
+ norB confers_resistance_to_antibiotic
+ quinolone resistance protein (qnr) [AMR Gene Family] confers_resistance_to_antibiotic
+ Bartonella bacilliformis gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Escherichia coli gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Mycobaterium leprae gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Staphylococcus aureus gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Morganella morganii gyrB conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Mycobacterium leprae gyrB conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Salmonella serovars gyrB conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Ureaplasma urealyticum gyrB conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Escherichia coli parC conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Mycoplasma hominis parC conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Staphylococcus aureus parC conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Streptococcus pneumoniae parC conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Ureaplasma urealyticum parC conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Escherichia coli parE conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Salmonella serovars parE conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Staphylococcus aureus parE conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis gyrB mutant conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Acinetobacter baumannii gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Acinetobacter baumannii parC conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ QepA2 confers_resistance_to_antibiotic
Publications

Oliphant CM and Green GM. 2002. Am Fam Physician 65(3): 455-464. Quinolones: a comprehensive review. (PMID 11858629)

Balfour JA and Wiseman LR. 1999. Drugs 57(3): 363-373. Moxifloxacin. (PMID 10193688)