quinolone resistance protein (qnr) [AMR Gene Family]

Accession ARO:3000419
DefinitionQnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics.
Drug Classfluoroquinolone antibiotic
Resistance Mechanismantibiotic target protection
Classification6 ontology terms | Show
Parent Term(s)9 ontology terms | Show
+ antibiotic target protection protein
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic gatifloxacin [Antibiotic]
+ confers_resistance_to_antibiotic levofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic moxifloxacin [Antibiotic]
+ confers_resistance_to_antibiotic nalidixic acid [Antibiotic]
+ confers_resistance_to_antibiotic norfloxacin [Antibiotic]
+ confers_resistance_to_antibiotic sparfloxacin [Antibiotic]
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
110 ontology terms | Show

Hegde SS, et al. 2005. Science 308(5727): 1480-1483. A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA. (PMID 15933203)

Wang M, et al. 2009. Antimicrob Agents Chemother 53(5): 1892-1897. New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. (PMID 19258263)

Strahilevitz J, et al. 2009. Clin Microbiol Rev 22(4): 664-689. Plasmid-mediated quinolone resistance: a multifaceted threat. (PMID 19822894)