quinolone resistance protein (qnr) [AMR Gene Family]

Accession ARO:3000419
Synonym(s)Qnr
DefinitionQnr proteins are pentapeptide repeat proteins that mimic DNA and protect the cell from the activity of fluoroquinolone antibiotics
Drug Classfluoroquinolone antibiotic
Resistance Mechanismantibiotic target protection
Classification6 ontology terms | Show
Parent Term(s)10 ontology terms | Show
+ antibiotic target protection protein
+ determinant of fluoroquinolone resistance
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic gatifloxacin [Antibiotic]
+ confers_resistance_to_antibiotic levofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic moxifloxacin [Antibiotic]
+ confers_resistance_to_antibiotic nalidixic acid [Antibiotic]
+ confers_resistance_to_antibiotic norfloxacin [Antibiotic]
+ confers_resistance_to_antibiotic sparfloxacin [Antibiotic]
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
Sub-Term(s)
110 ontology terms | Show
Publications

Hegde SS, et al. 2005. Science 308(5727): 1480-1483. A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA. (PMID 15933203)

Wang M, et al. 2009. Antimicrob Agents Chemother 53(5): 1892-1897. New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. (PMID 19258263)

Strahilevitz J, et al. 2009. Clin Microbiol Rev 22(4): 664-689. Plasmid-mediated quinolone resistance: a multifaceted threat. (PMID 19822894)