Accession ARO:3003844
CARD Short Namemfd
Definitionmfd dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. The Mfd (mutation frequency decline) protein, also known as transcription-repair coupling factor, is responsible for ATP-dependent removal of stalled RNA polymerase from DNA lesions by inducing forward movement of the RNA polymerase and subsequent recruitment of nucleotide excision repair machinery to the sites of the lesions.
AMR Gene Familyquinolone resistance protein (qnr)
Drug Classfluoroquinolone antibiotic
Resistance Mechanismantibiotic target protection
Classification14 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ quinolone resistance protein (qnr) [AMR Gene Family]
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]

Deaconescu AM, et al. 2007. Curr. Opin. Struct. Biol. 17(1):96-102 The bacterial transcription repair coupling factor. (PMID 17239578)

Han J, et al. 2008. PLoS Pathog 4(6): E1000083. Key role of Mfd in the development of fluoroquinolone resistance in Campylobacter jejuni. (PMID 18535657)

Private model - RGI is not currently using this model.