Accession | ARO:3003844 |
CARD Short Name | mfd |
Definition | mfd dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. The Mfd (mutation frequency decline) protein, also known as transcription-repair coupling factor, is responsible for ATP-dependent removal of stalled RNA polymerase from DNA lesions by inducing forward movement of the RNA polymerase and subsequent recruitment of nucleotide excision repair machinery to the sites of the lesions. |
AMR Gene Family | quinolone resistance protein (qnr) |
Drug Class | fluoroquinolone antibiotic |
Resistance Mechanism | antibiotic target protection |
Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + fluoroquinolone antibiotic [Drug Class] + determinant of antibiotic resistance + antibiotic target protection [Resistance Mechanism] + sparfloxacin [Antibiotic] + gatifloxacin [Antibiotic] + moxifloxacin [Antibiotic] + antibiotic target protection protein + nalidixic acid [Antibiotic] + ciprofloxacin [Antibiotic] + norfloxacin [Antibiotic] + levofloxacin [Antibiotic] |
Parent Term(s) | 2 ontology terms | Show + quinolone resistance protein (qnr) [AMR Gene Family] + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] |
Publications | Deaconescu AM, et al. 2007. Curr. Opin. Struct. Biol. 17(1):96-102 The bacterial transcription repair coupling factor. (PMID 17239578) Han J, et al. 2008. PLoS Pathog 4(6): E1000083. Key role of Mfd in the development of fluoroquinolone resistance in Campylobacter jejuni. (PMID 18535657) |
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