| Accession | ARO:3002799 |
| CARD Short Name | QnrVC1 |
| Definition | QnrVC1 is an integron-mediated quinolone resistance protein found in Vibrio cholerae. |
| AMR Gene Family | quinolone resistance protein (qnr) |
| Drug Class | fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Resistomes with Perfect Matches | Aeromonas caviaeg+wgs, Enterobacter cloacaewgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Escherichia colip, Klebsiella pneumoniaewgs, Klebsiella quasipneumoniaewgs, Providencia stuartiiwgs, Pseudomonas aeruginosag+p+wgs+gi, Pseudomonas mendocinap+wgs, Pseudomonas monteiliiwgs, Pseudomonas putidap+wgs, Pseudomonas stutzerig+p+wgs, Shewanella putrefaciensg, Vibrio alginolyticusg+wgs, Vibrio choleraeg+wgs, Vibrio parahaemolyticuswgs, Vibrio vulnificuswgs |
| Resistomes with Sequence Variants | Aeromonas caviaeg+wgs, Enterobacter cloacaewgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Escherichia colip, Klebsiella pneumoniaewgs, Klebsiella quasipneumoniaewgs, Providencia stuartiiwgs, Pseudomonas aeruginosag+p+wgs+gi, Pseudomonas mendocinap+wgs, Pseudomonas monteiliiwgs, Pseudomonas putidap+wgs, Pseudomonas stutzerig+p+wgs, Shewanella putrefaciensg, Vibrio alginolyticusg+wgs, Vibrio choleraeg+wgs, Vibrio parahaemolyticusg+wgs, Vibrio vulnificuswgs |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + fluoroquinolone antibiotic [Drug Class] + antibiotic target protection [Resistance Mechanism] + determinant of antibiotic resistance + nalidixic acid [Antibiotic] + gatifloxacin [Antibiotic] + sparfloxacin [Antibiotic] + norfloxacin [Antibiotic] + moxifloxacin [Antibiotic] + levofloxacin [Antibiotic] + antibiotic target protection protein + ciprofloxacin [Antibiotic] |
| Parent Term(s) | 2 ontology terms | Show + quinolone resistance protein (qnr) [AMR Gene Family] + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] |
| Publications | Fonseca EL, et al. 2008. Emerg Infect Dis 14(7): 1129-1131. New qnr gene cassettes associated with superintegron repeats in Vibrio cholerae O1. (PMID 18598639) |
Prevalence of QnrVC1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Aeromonas caviae | 2.27% | 0% | 1.08% | 0% |
| Enterobacter cloacae | 0% | 0% | 0.32% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.09% | 0% |
| Enterobacter kobei | 0% | 0% | 0.87% | 0% |
| Escherichia coli | 0% | 0.01% | 0% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.01% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.26% | 0% |
| Providencia stuartii | 0% | 0% | 2.27% | 0% |
| Pseudomonas aeruginosa | 1.99% | 2.92% | 1.25% | 5.56% |
| Pseudomonas mendocina | 0% | 50% | 7.14% | 0% |
| Pseudomonas monteilii | 0% | 0% | 4.76% | 0% |
| Pseudomonas putida | 0% | 4% | 2.67% | 0% |
| Pseudomonas stutzeri | 3.57% | 9.09% | 2.29% | 0% |
| Shewanella putrefaciens | 11.11% | 0% | 0% | 0% |
| Vibrio alginolyticus | 3.7% | 0% | 3.97% | 0% |
| Vibrio cholerae | 0.45% | 0% | 1.34% | 0% |
| Vibrio parahaemolyticus | 0.32% | 0% | 0.31% | 0% |
| Vibrio vulnificus | 0% | 0% | 1.22% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 400