| Accession | ARO:3002707 |
| CARD Short Name | QnrA1 |
| Definition | QnrA1 is a plasmid-mediated quinolone resistance protein found in Klebsiella pneumoniae. |
| AMR Gene Family | quinolone resistance protein (qnr) |
| Drug Class | fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Resistomes with Perfect Matches | Citrobacter freundiip+wgs, Citrobacter portucalensiswgs, Citrobacter werkmaniiwgs, Edwardsiella tardawgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia colip+wgs, Klebsiella aerogeneswgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocap+wgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaep+wgs, Proteus mirabilisp+wgs, Proteus vulgarisp+wgs, Providencia rettgerip+wgs, Providencia stuartiiwgs, Pseudomonas aeruginosawgs, Raoultella planticolawgs, Salmonella entericawgs, Serratia marcescensp+wgs, Shewanella putrefaciensp, Vibrio alginolyticuswgs |
| Resistomes with Sequence Variants | Citrobacter freundiip+wgs, Citrobacter portucalensiswgs, Citrobacter werkmaniiwgs, Edwardsiella tardawgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia colip+wgs, Klebsiella aerogeneswgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocap+wgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaep+wgs, Proteus mirabilisp+wgs, Proteus vulgarisp+wgs, Providencia rettgerip+wgs, Providencia stuartiiwgs, Pseudomonas aeruginosawgs, Raoultella planticolawgs, Salmonella entericawgs, Serratia marcescensp+wgs, Shewanella putrefaciensp, Vibrio alginolyticuswgs |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + fluoroquinolone antibiotic [Drug Class] + antibiotic target protection [Resistance Mechanism] + determinant of antibiotic resistance + nalidixic acid [Antibiotic] + antibiotic target protection protein + sparfloxacin [Antibiotic] + gatifloxacin [Antibiotic] + ciprofloxacin [Antibiotic] + norfloxacin [Antibiotic] + moxifloxacin [Antibiotic] + levofloxacin [Antibiotic] |
| Parent Term(s) | 2 ontology terms | Show + quinolone resistance protein (qnr) [AMR Gene Family] + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] |
| Publications | Tran JH and Jacoby GA. 2002. Proc Natl Acad Sci U S A 99(8): 5638-5642. Mechanism of plasmid-mediated quinolone resistance. (PMID 11943863) |
Prevalence of QnrA1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Citrobacter freundii | 0% | 1.23% | 6% | 0% |
| Citrobacter portucalensis | 0% | 0% | 3.6% | 0% |
| Citrobacter werkmanii | 0% | 0% | 10.26% | 0% |
| Edwardsiella tarda | 0% | 0% | 6.67% | 0% |
| Enterobacter asburiae | 0% | 0.55% | 5.53% | 0% |
| Enterobacter chengduensis | 0% | 0% | 4% | 0% |
| Enterobacter cloacae | 0% | 3.91% | 5.11% | 0% |
| Enterobacter hormaechei | 0.36% | 2.19% | 6.73% | 0% |
| Enterobacter kobei | 0% | 1.38% | 8.73% | 0% |
| Enterobacter roggenkampii | 0% | 0.97% | 3.6% | 0% |
| Escherichia coli | 0% | 0.04% | 0.11% | 0% |
| Klebsiella aerogenes | 0% | 0% | 0.28% | 0% |
| Klebsiella michiganensis | 0% | 0.57% | 0.8% | 0% |
| Klebsiella oxytoca | 0% | 0.68% | 0.42% | 0% |
| Klebsiella pneumoniae | 0% | 0.13% | 0.41% | 0% |
| Klebsiella quasipneumoniae | 0% | 0.85% | 1.05% | 0% |
| Proteus mirabilis | 0% | 2.5% | 1.98% | 0% |
| Proteus vulgaris | 0% | 11.11% | 5.56% | 0% |
| Providencia rettgeri | 0% | 2.7% | 2.55% | 0% |
| Providencia stuartii | 0% | 0% | 2.27% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.04% | 0% |
| Raoultella planticola | 0% | 0% | 2.56% | 0% |
| Salmonella enterica | 0% | 0% | 0.04% | 0% |
| Serratia marcescens | 0% | 0.65% | 0.52% | 0% |
| Shewanella putrefaciens | 0% | 20% | 0% | 0% |
| Vibrio alginolyticus | 0% | 0% | 0.79% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 400