QnrB2

Accession ARO:3002715
CARD Short NameQnrB2
DefinitionQnrB2 is a plasmid-mediated quinolone resistance protein found in Citrobacter koseri.
AMR Gene Familyquinolone resistance protein (qnr)
Drug Classfluoroquinolone antibiotic
Resistance Mechanismantibiotic target protection
Resistomes with Perfect MatchesEnterobacter cloacaewgs, Enterobacter hormaecheip+wgs, Klebsiella aerogenesg, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaewgs
Resistomes with Sequence VariantsCitrobacter freundiiwgs, Enterobacter cloacaewgs, Enterobacter hormaecheip+wgs, Escherichia colip, Klebsiella aerogenesg+wgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaep+wgs, Raoultella planticolap, Shigella flexnerip
Classification14 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ quinolone resistance protein (qnr) [AMR Gene Family]
+ confers_resistance_to_antibiotic ciprofloxacin [Antibiotic]
Publications

Jacoby GA, et al. 2006. Antimicrob Agents Chemother 50(4): 1178-1182. qnrB, another plasmid-mediated gene for quinolone resistance. (PMID 16569827)

Resistomes

Prevalence of QnrB2 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Citrobacter freundii0%0%0.19%0%
Enterobacter cloacae0%0%0.32%0%
Enterobacter hormaechei0%0.06%0.3%0%
Escherichia coli0%0.01%0%0%
Klebsiella aerogenes2%0%0.28%0%
Klebsiella pneumoniae0%0.49%0.85%0%
Klebsiella quasipneumoniae0%0.21%0.39%0%
Raoultella planticola0%2.33%0%0%
Shigella flexneri0%0.4%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 400


>gb|ABO93588.1|+|QnrB2 [Proteus mirabilis]
MALALVGEKINRNRFTGEKIENSTFFNCDFSGADLSGTEFIGCQFYDRESQKGCNFSRAMLKDAIFKSCDLSMADFRNASALGIEISHCR
AQGADFRGASFMNMITTRTWFCSAYITNTNLSYANFSKVVLEKCELWENRWMGAQVLGATFSGSDLSGGEFSTFDWRAANFTHCDLTNSE
LGDLDIRRVDLQGVKLDNYQASLLMERLGIAIIG


>gb|EF488762.1|+|1-645|QnrB2 [Proteus mirabilis]
ATGGCTCTGGCACTCGTTGGCGAAAAAATTAACAGAAACCGCTTCACCGGTGAGAAAATTGAAAATAGTACATTTTTTAACTGTGATTTT
TCAGGTGCCGACCTGAGCGGCACTGAATTTATCGGCTGTCAGTTCTATGATCGTGAAAGCCAGAAAGGGTGCAATTTTAGTCGTGCGATG
CTGAAAGATGCCATTTTTAAAAGCTGTGATTTATCCATGGCGGATTTTCGCAATGCCAGTGCGCTTGGCATTGAAATTAGCCACTGTCGT
GCGCAAGGCGCAGATTTTCGCGGCGCAAGTTTTATGAATATGATCACTACTCGCACCTGGTTTTGCAGTGCATATATCACTAACACAAAT
CTAAGCTACGCCAATTTTTCGAAAGTCGTGTTGGAAAAGTGTGAGCTGTGGGAAAACCGTTGGATGGGGGCCCAGGTACTGGGCGCGACG
TTCAGTGGTTCAGATCTCTCCGGCGGCGAGTTTTCGACTTTCGACTGGCGAGCAGCAAACTTCACACATTGCGATCTGACCAATTCGGAG
TTGGGTGACTTAGATATTCGGCGCGTTGATTTACAAGGCGTTAAGTTGGACAACTACCAGGCATCGTTGCTCATGGAACGTCTTGGCATC
GCGATTATTGGCTAG