| Accession | ARO:3002724 |
| CARD Short Name | QnrB10 |
| Definition | QnrB10 is a plasmid-mediated quinolone resistance protein found in Citrobacter freundii. |
| AMR Gene Family | quinolone resistance protein (qnr) |
| Drug Class | fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Resistomes with Perfect Matches | Enterobacter asburiaep, Enterobacter hormaecheiwgs, Escherichia colip, Klebsiella oxytocawgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Aeromonas hydrophilap, Bifidobacterium bifidumwgs, Burkholderia multivoransp, Citrobacter amalonaticuswgs, Citrobacter freundiig+p+wgs, Citrobacter portucalensisg+wgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaewgs, Enterobacter hormaecheip+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiig+p+wgs, Escherichia colig+p+wgs, Escherichia fergusoniiwgs, Helicobacter pyloriwgs, Klebsiella aerogeneswgs, Klebsiella michiganensiswgs, Klebsiella oxytocawgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatawgs, Proteus mirabiliswgs, Pseudomonas aeruginosawgs, Salmonella entericap+wgs, Serratia marcescenswgs, Shigella flexneriwgs, Shigella sonneiwgs, Staphylococcus aureuswgs |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic target protection [Resistance Mechanism] + fluoroquinolone antibiotic [Drug Class] + sparfloxacin [Antibiotic] + norfloxacin [Antibiotic] + nalidixic acid [Antibiotic] + gatifloxacin [Antibiotic] + antibiotic target protection protein + moxifloxacin [Antibiotic] + levofloxacin [Antibiotic] + ciprofloxacin [Antibiotic] |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] + quinolone resistance protein (qnr) [AMR Gene Family] |
| Publications | Quiroga MP, et al. 2007. Antimicrob Agents Chemother 51(12): 4466-4470. Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. (PMID 17938184) |
Prevalence of QnrB10 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.01% | 0% |
| Aeromonas hydrophila | 0% | 1.3% | 0% | 0% |
| Bifidobacterium bifidum | 0% | 0% | 0.5% | 0% |
| Burkholderia multivorans | 0% | 2.94% | 0% | 0% |
| Citrobacter amalonaticus | 0% | 0% | 1.82% | 0% |
| Citrobacter freundii | 2.46% | 0.31% | 1.55% | 0% |
| Citrobacter portucalensis | 3.7% | 0% | 0.9% | 0% |
| Enterobacter asburiae | 0% | 0.28% | 0.79% | 0% |
| Enterobacter chengduensis | 0% | 0% | 8% | 0% |
| Enterobacter cloacae | 0% | 0% | 0.32% | 0% |
| Enterobacter hormaechei | 0% | 0.19% | 1.99% | 0% |
| Enterobacter kobei | 0% | 1.38% | 2.18% | 0% |
| Enterobacter roggenkampii | 2.33% | 0.48% | 0.72% | 0% |
| Escherichia coli | 0.07% | 0.16% | 0.49% | 0% |
| Escherichia fergusonii | 0% | 0% | 1.09% | 0% |
| Helicobacter pylori | 0% | 0% | 0.05% | 0% |
| Klebsiella aerogenes | 0% | 0% | 0.28% | 0% |
| Klebsiella michiganensis | 0% | 0% | 0.27% | 0% |
| Klebsiella oxytoca | 0% | 0% | 0.42% | 0% |
| Klebsiella pneumoniae | 0% | 0.14% | 0.51% | 0% |
| Klebsiella quasipneumoniae | 0% | 0.21% | 1.18% | 0% |
| Leclercia adecarboxylata | 0% | 0% | 2.33% | 0% |
| Proteus mirabilis | 0% | 0% | 0.17% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.01% | 0% |
| Salmonella enterica | 0% | 0.66% | 0.51% | 0% |
| Serratia marcescens | 0% | 0% | 0.66% | 0% |
| Shigella flexneri | 0% | 0% | 0.16% | 0% |
| Shigella sonnei | 0% | 0% | 0.37% | 0% |
| Staphylococcus aureus | 0% | 0% | 0.01% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 400