| Accession | ARO:3002720 |
| CARD Short Name | QnrB6 |
| Definition | QnrB6 is a plasmid-mediated quinolone resistance protein found in Pantoea agglomerans. |
| AMR Gene Family | quinolone resistance protein (qnr) |
| Drug Class | fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Resistomes with Perfect Matches | Acinetobacter nosocomialiswgs, Citrobacter freundiig+p+wgs, Citrobacter koseriwgs, Citrobacter portucalensisg+p+wgs, Enterobacter asburiaep+wgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter kobeiwgs, Escherichia colip+wgs, Escherichia fergusoniiwgs, Klebsiella aerogeneswgs, Klebsiella huaxiensisg+gi, Klebsiella michiganensisp+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatap+wgs, Pseudomonas aeruginosawgs, Raoultella planticolap, Salmonella entericag+p+wgs, Serratia marcescenswgs, Shigella flexnerip+wgs |
| Resistomes with Sequence Variants | Acinetobacter nosocomialiswgs, Citrobacter freundiig+p+wgs, Citrobacter koseriwgs, Citrobacter portucalensisg+p+wgs+gi, Enterobacter asburiaep+wgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter kobeiwgs, Enterobacter roggenkampiip+wgs, Escherichia colip+wgs, Escherichia fergusoniiwgs, Klebsiella aerogeneswgs, Klebsiella huaxiensisg+gi, Klebsiella michiganensisp+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaep+wgs, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatap+wgs, Pseudomonas aeruginosawgs, Raoultella planticolap, Salmonella entericag+p+wgs, Serratia marcescenswgs, Shigella flexnerip+wgs |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + fluoroquinolone antibiotic [Drug Class] + determinant of antibiotic resistance + antibiotic target protection [Resistance Mechanism] + moxifloxacin [Antibiotic] + sparfloxacin [Antibiotic] + gatifloxacin [Antibiotic] + levofloxacin [Antibiotic] + ciprofloxacin [Antibiotic] + norfloxacin [Antibiotic] + nalidixic acid [Antibiotic] + antibiotic target protection protein |
| Parent Term(s) | 2 ontology terms | Show + quinolone resistance protein (qnr) [AMR Gene Family] + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] |
| Publications | Sanchez-Cespedes J, et al. 2009. Clin Microbiol Infect 15(12): 1132-1138. Two chromosomally located qnrB variants, qnrB6 and the new qnrB16, in Citrobacter spp. isolates causing bacteraemia. (PMID 19392890) |
Prevalence of QnrB6 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter nosocomialis | 0% | 0% | 0.57% | 0% |
| Citrobacter freundii | 1.64% | 0.31% | 3.29% | 0% |
| Citrobacter koseri | 0% | 0% | 0.9% | 0% |
| Citrobacter portucalensis | 11.11% | 1.47% | 9.91% | 100% |
| Enterobacter asburiae | 0% | 0.55% | 2.37% | 0% |
| Enterobacter cloacae | 0% | 0.56% | 1.92% | 0% |
| Enterobacter hormaechei | 0% | 3.86% | 5.96% | 0% |
| Enterobacter kobei | 0% | 0% | 0.44% | 0% |
| Enterobacter roggenkampii | 0% | 0.48% | 0.72% | 0% |
| Escherichia coli | 0% | 0.05% | 0.15% | 0% |
| Escherichia fergusonii | 0% | 0% | 1.09% | 0% |
| Klebsiella aerogenes | 0% | 0% | 0.56% | 0% |
| Klebsiella huaxiensis | 100% | 0% | 0% | 50% |
| Klebsiella michiganensis | 0% | 0.57% | 1.33% | 0% |
| Klebsiella oxytoca | 0% | 0% | 0.42% | 0% |
| Klebsiella pneumoniae | 0% | 0.28% | 1.38% | 0% |
| Klebsiella quasipneumoniae | 0% | 1.27% | 2.63% | 0% |
| Leclercia adecarboxylata | 0% | 4.76% | 4.65% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.01% | 0% |
| Raoultella planticola | 0% | 2.33% | 0% | 0% |
| Salmonella enterica | 0.13% | 0.16% | 0.09% | 0% |
| Serratia marcescens | 0% | 0% | 0.52% | 0% |
| Shigella flexneri | 0% | 0.4% | 0.16% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 400