QnrB6

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Accession	ARO:3002720
CARD Short Name	QnrB6
Definition	QnrB6 is a plasmid-mediated quinolone resistance protein found in Pantoea agglomerans.
AMR Gene Family	quinolone resistance protein (qnr)
Drug Class	fluoroquinolone antibiotic
Resistance Mechanism	antibiotic target protection
Resistomes with Perfect Matches	Acinetobacter nosocomialis^wgs, Citrobacter freundii^g+p+wgs, Citrobacter koseri^wgs, Citrobacter portucalensis^g+p+wgs, Enterobacter asburiae^p+wgs, Enterobacter cloacae^p+wgs, Enterobacter hormaechei^p+wgs, Enterobacter kobei^wgs, Escherichia coli^p+wgs, Escherichia fergusonii^wgs, Klebsiella aerogenes^wgs, Klebsiella huaxiensis^g+gi, Klebsiella michiganensis^p+wgs, Klebsiella oxytoca^wgs, Klebsiella pneumoniae^p+wgs, Klebsiella quasipneumoniae^p+wgs, Leclercia adecarboxylata^p+wgs, Pseudomonas aeruginosa^wgs, Raoultella planticola^p, Salmonella enterica^g+p+wgs, Serratia marcescens^wgs, Shigella flexneri^p+wgs
Resistomes with Sequence Variants	Acinetobacter nosocomialis^wgs, Citrobacter freundii^g+p+wgs, Citrobacter koseri^wgs, Citrobacter portucalensis^g+p+wgs+gi, Enterobacter asburiae^p+wgs, Enterobacter cloacae^p+wgs, Enterobacter hormaechei^p+wgs, Enterobacter kobei^wgs, Enterobacter roggenkampii^p+wgs, Escherichia coli^p+wgs, Escherichia fergusonii^wgs, Klebsiella aerogenes^wgs, Klebsiella huaxiensis^g+gi, Klebsiella michiganensis^p+wgs, Klebsiella oxytoca^wgs, Klebsiella pneumoniae^p+wgs, Klebsiella quasipneumoniae^p+wgs, Leclercia adecarboxylata^p+wgs, Pseudomonas aeruginosa^wgs, Raoultella planticola^p, Salmonella enterica^g+p+wgs, Serratia marcescens^wgs, Shigella flexneri^p+wgs
Classification	14 ontology terms \| Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic target protection [Resistance Mechanism] + fluoroquinolone antibiotic [Drug Class] + sparfloxacin [Antibiotic] + norfloxacin [Antibiotic] + nalidixic acid [Antibiotic] + gatifloxacin [Antibiotic] + antibiotic target protection protein + moxifloxacin [Antibiotic] + levofloxacin [Antibiotic] + ciprofloxacin [Antibiotic]
Parent Term(s)	2 ontology terms \| Show + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] + quinolone resistance protein (qnr) [AMR Gene Family]
Publications	Sanchez-Cespedes J, et al. 2009. Clin Microbiol Infect 15(12): 1132-1138. Two chromosomally located qnrB variants, qnrB6 and the new qnrB16, in Citrobacter spp. isolates causing bacteraemia. (PMID 19392890)

Resistomes

Prevalence of QnrB6 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

Species	NCBI Chromosome	NCBI Plasmid	NCBI WGS	NCBI GI	GRDI-AMR2
Acinetobacter nosocomialis	0%	0%	0.57%	0%	0%
Acinetobacter nosocomialis	0%	0%	0.57%	0%	0%
Citrobacter freundii	1.64%	0.31%	3.48%	0%	0%
Citrobacter freundii	1.64%	0.31%	3.29%	0%	0%
Citrobacter koseri	0%	0%	0.9%	0%	0%
Citrobacter koseri	0%	0%	0.9%	0%	0%
Citrobacter portucalensis	11.11%	1.47%	11.71%	100%	0%
Citrobacter portucalensis	11.11%	1.47%	9.91%	0%	0%
Enterobacter asburiae	0%	0.55%	2.37%	0%	0%
Enterobacter asburiae	0%	0.55%	2.37%	0%	0%
Enterobacter cloacae	0%	0.56%	1.92%	0%	0%
Enterobacter cloacae	0%	0.56%	1.92%	0%	0%
Enterobacter hormaechei	0%	3.22%	5.14%	0%	0%
Enterobacter hormaechei	0%	3.86%	6.04%	0%	0%
Enterobacter kobei	0%	0%	0.44%	0%	0%
Enterobacter kobei	0%	0%	0.44%	0%	0%
Enterobacter roggenkampii	0%	0.48%	1.08%	0%	0%
Enterobacter roggenkampii	0%	0%	0%	0%	0%
Escherichia coli	0%	0.05%	0.18%	0%	0%
Escherichia coli	0%	0.05%	0.18%	0%	0%
Escherichia fergusonii	0%	0%	1.09%	0%	0%
Escherichia fergusonii	0%	0%	1.09%	0%	0%
Klebsiella aerogenes	0%	0%	0.56%	0%	0%
Klebsiella aerogenes	0%	0%	0.56%	0%	0%
Klebsiella huaxiensis	100%	0%	0%	50%	0%
Klebsiella huaxiensis	100%	0%	0%	50%	0%
Klebsiella michiganensis	0%	0.57%	1.86%	0%	0%
Klebsiella michiganensis	0%	0.57%	1.86%	0%	0%
Klebsiella oxytoca	0%	0%	0.42%	0%	0%
Klebsiella oxytoca	0%	0%	0.42%	0%	0%
Klebsiella pneumoniae	0%	0.25%	1.64%	0%	0%
Klebsiella pneumoniae	0%	0.28%	1.67%	0%	0%
Klebsiella quasipneumoniae	0%	1.27%	2.63%	0%	0%
Klebsiella quasipneumoniae	0%	1.27%	2.5%	0%	0%
Leclercia adecarboxylata	0%	4.76%	4.65%	0%	0%
Leclercia adecarboxylata	0%	4.76%	4.65%	0%	0%
Pseudomonas aeruginosa	0%	0%	0.01%	0%	0%
Pseudomonas aeruginosa	0%	0%	0.01%	0%	0%
Raoultella planticola	0%	2.33%	0%	0%	0%
Raoultella planticola	0%	2.33%	0%	0%	0%
Salmonella enterica	0.13%	0.16%	0.28%	0%	0%
Salmonella enterica	0.13%	0.16%	0.29%	0%	0%
Serratia marcescens	0%	0%	0.79%	0%	0%
Serratia marcescens	0%	0%	0.79%	0%	0%
Shigella flexneri	0%	0.4%	0.16%	0%	0%
Shigella flexneri	0%	0.4%	0.16%	0%	0%

Show Perfect Only

Detection Models

protein homolog model

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 400

Protein
DNA

>gb|ABP87778.1|+|QnrB6 [Pantoea agglomerans]
MTPLLYKKTGTNMALALVGEKIDRNRFTGEKIENSTFFNCDFSGADLSGTEFIGCQFYDRESQKGCNFSRAMLKDAIFKSCDLSMADFRN
ASALGIEIRHCRAQGADFRGASFMNMITTRTWFCSAYITNTNLSYANFSKVVLEKCELWENRWMGAQVLGATFSGSDLSGGEFSTFDWRA
ANFTHCDLTNSELGDLDIRGVDLQGVKLDNYQASLLMERLGIAVIG

>gb|EF520349.1|+|1-681|QnrB6 [Pantoea agglomerans]
ATGACGCCATTACTGTATAAAAAAACAGGTACAAATATGGCTCTGGCACTCGTTGGCGAAAAAATTGACAGAAACCGTTTCACCGGTGAG
AAAATTGAAAATAGTACATTTTTTAACTGTGATTTTTCAGGTGCCGACCTGAGCGGCACTGAATTTATCGGCTGTCAGTTCTATGATCGT
GAAAGCCAGAAAGGGTGCAATTTTAGTCGTGCGATGCTGAAAGATGCCATTTTTAAAAGCTGTGATTTATCCATGGCGGATTTTCGCAAT
GCCAGTGCGCTGGGCATTGAAATTCGCCACTGCCGCGCACAAGGCGCAGATTTCCGCGGCGCAAGCTTTATGAATATGATCACCACGCGC
ACCTGGTTTTGTAGCGCATATATCACGAATACCAATCTAAGCTACGCCAATTTTTCGAAAGTCGTGTTGGAAAAGTGTGAGCTGTGGGAA
AACCGTTGGATGGGTGCCCAGGTACTGGGCGCGACGTTCAGTGGTTCAGATCTCTCCGGCGGCGAGTTTTCGACTTTCGACTGGCGAGCA
GCAAACTTCACACATTGCGATCTGACCAATTCGGAGTTGGGTGACTTAGATATTCGGGGCGTTGATTTACAAGGCGTTAAGCTGGACAAC
TACCAGGCGTCGTTGCTCATGGAGCGGCTTGGCATCGCGGTGATTGGTTAG

Curator Acknowledgements

Curator	Description	Most Recent Edit

QnrB6

Prevalence: protein homolog model (view sequences)

Graph