Accession | ARO:3002788 |
CARD Short Name | QnrD1 |
Definition | QnrD1 is a plasmid-mediated quinolone resistance protein found in Salmonella enterica. |
AMR Gene Family | quinolone resistance protein (qnr) |
Drug Class | fluoroquinolone antibiotic |
Resistance Mechanism | antibiotic target protection |
Resistomes with Perfect Matches | Alcaligenes faecaliswgs, Enterobacter hormaecheiwgs, Escherichia coliwgs, Klebsiella pneumoniaewgs, Morganella morganiip+wgs, Proteus columbaewgs, Proteus mirabilisp+wgs, Proteus penneriwgs, Proteus vulgarisp+wgs, Providencia heimbachaewgs, Providencia rettgerip+wgs, Providencia stuartiip+wgs, Salmonella entericawgs, Serratia marcescenswgs, Vibrio choleraewgs, Vibrio parahaemolyticuswgs |
Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Alcaligenes faecaliswgs, Citrobacter freundiip, Cronobacter sakazakiiwgs, Delftia tsuruhatensiswgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Escherichia coliwgs, Klebsiella pneumoniaewgs, Klebsiella quasipneumoniaewgs, Morganella morganiip+wgs, Mycobacterium tuberculosiswgs, Proteus columbaewgs, Proteus mirabilisp+wgs, Proteus penneriwgs, Proteus vulgarisp+wgs, Providencia heimbachaewgs, Providencia rettgerip+wgs, Providencia stuartiip+wgs, Pseudomonas aeruginosawgs, Salmonella entericawgs, Serratia marcescenswgs, Staphylococcus simulanswgs, Stenotrophomonas maltophiliawgs, Vibrio choleraewgs, Vibrio parahaemolyticuswgs |
Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + fluoroquinolone antibiotic [Drug Class] + antibiotic target protection [Resistance Mechanism] + determinant of antibiotic resistance + norfloxacin [Antibiotic] + antibiotic target protection protein + moxifloxacin [Antibiotic] + levofloxacin [Antibiotic] + gatifloxacin [Antibiotic] + nalidixic acid [Antibiotic] + sparfloxacin [Antibiotic] + ciprofloxacin [Antibiotic] |
Parent Term(s) | 2 ontology terms | Show + quinolone resistance protein (qnr) [AMR Gene Family] + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] |
Publications | Cavaco LM, et al. 2009. Antimicrob Agents Chemother 53(2): 603-608. qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. (PMID 19029321) |
Prevalence of QnrD1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
---|---|---|---|---|
Acinetobacter baumannii | 0% | 0% | 0.02% | 0% |
Alcaligenes faecalis | 0% | 0% | 3.85% | 0% |
Citrobacter freundii | 0% | 0.32% | 0% | 0% |
Cronobacter sakazakii | 0% | 0% | 0.24% | 0% |
Delftia tsuruhatensis | 0% | 0% | 14.29% | 0% |
Enterobacter hormaechei | 0% | 0% | 0.14% | 0% |
Enterobacter kobei | 0% | 0% | 0.52% | 0% |
Escherichia coli | 0% | 0% | 0.09% | 0% |
Klebsiella pneumoniae | 0% | 0% | 0.09% | 0% |
Klebsiella quasipneumoniae | 0% | 0% | 0.16% | 0% |
Morganella morganii | 0% | 8.11% | 8.28% | 0% |
Mycobacterium tuberculosis | 0% | 0% | 0.02% | 0% |
Proteus columbae | 0% | 0% | 100% | 0% |
Proteus mirabilis | 0% | 7.46% | 6.38% | 0% |
Proteus penneri | 0% | 0% | 16.67% | 0% |
Proteus vulgaris | 0% | 12.5% | 13.33% | 0% |
Providencia heimbachae | 0% | 0% | 33.33% | 0% |
Providencia rettgeri | 0% | 2.78% | 33.09% | 0% |
Providencia stuartii | 0% | 7.14% | 2.27% | 0% |
Pseudomonas aeruginosa | 0% | 0% | 0.02% | 0% |
Salmonella enterica | 0% | 0% | 0.08% | 0% |
Serratia marcescens | 0% | 0% | 0.28% | 0% |
Staphylococcus simulans | 0% | 0% | 1.67% | 0% |
Stenotrophomonas maltophilia | 0% | 0% | 0.17% | 0% |
Vibrio cholerae | 0% | 0% | 1.38% | 0% |
Vibrio parahaemolyticus | 0% | 0% | 1% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 400