| Accession | ARO:3002790 |
| CARD Short Name | QnrS1 |
| Definition | QnrS1 is a plasmid-mediated quinolone resistance protein found in Shigella flexneri. |
| AMR Gene Family | quinolone resistance protein (qnr) |
| Drug Class | fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Resistomes with Perfect Matches | Acinetobacter baumanniiwgs, Citrobacter amalonaticusp+wgs, Citrobacter freundiip+wgs, Citrobacter koserip+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniip, Citrobacter youngaep+wgs, Cronobacter malonaticuswgs, Cronobacter sakazakiip, Edwardsiella tardap+wgs, Enterobacter asburiaewgs, Enterobacter chengduensisp+wgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia albertiip+wgs, Escherichia colig+p+wgs+gi, Escherichia fergusoniig+p+wgs, Escherichia marmotaep, Klebsiella aerogenesg+p+wgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocap+wgs, Klebsiella pneumoniaeg+p+wgs+gi, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatag+p+wgs, Morganella morganiip+wgs, Proteus mirabilisg+wgs+gi, Raoultella planticolap+wgs, Salmonella entericag+p+wgs+gi, Serratia liquefaciensp, Serratia marcescensg+p+wgs+gi, Shigella boydiip+wgs, Shigella dysenteriaewgs, Shigella flexnerip+wgs, Shigella sonneip+wgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Citrobacter amalonaticusp+wgs, Citrobacter freundiip+wgs, Citrobacter koserip+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniip, Citrobacter youngaep+wgs, Cronobacter dublinensiswgs, Cronobacter malonaticuswgs, Cronobacter sakazakiip, Edwardsiella tardap+wgs, Enterobacter asburiaewgs, Enterobacter chengduensisp+wgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia albertiip+wgs, Escherichia colig+p+wgs+gi, Escherichia fergusoniig+p+wgs, Escherichia marmotaep, Klebsiella aerogenesg+p+wgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocap+wgs, Klebsiella pneumoniaeg+p+wgs+gi, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatag+p+wgs, Morganella morganiip+wgs, Proteus mirabilisg+wgs+gi, Raoultella planticolap+wgs, Salmonella entericag+p+wgs+gi, Serratia liquefaciensp, Serratia marcescensg+p+wgs+gi, Shigella boydiip+wgs, Shigella dysenteriaewgs, Shigella flexnerip+wgs, Shigella sonneip+wgs |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic target protection [Resistance Mechanism] + fluoroquinolone antibiotic [Drug Class] + sparfloxacin [Antibiotic] + norfloxacin [Antibiotic] + nalidixic acid [Antibiotic] + gatifloxacin [Antibiotic] + antibiotic target protection protein + moxifloxacin [Antibiotic] + levofloxacin [Antibiotic] + ciprofloxacin [Antibiotic] |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] + quinolone resistance protein (qnr) [AMR Gene Family] |
| Publications | Hata M, et al. 2005. Antimicrob Agents Chemother 49(2): 801-803. Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b. (PMID 15673773) |
Prevalence of QnrS1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.04% | 0% |
| Citrobacter amalonaticus | 0% | 8.33% | 7.27% | 0% |
| Citrobacter freundii | 0% | 1.23% | 6.19% | 0% |
| Citrobacter koseri | 0% | 5% | 0.9% | 0% |
| Citrobacter portucalensis | 0% | 1.47% | 9.91% | 0% |
| Citrobacter werkmanii | 0% | 10% | 0% | 0% |
| Citrobacter youngae | 0% | 9.09% | 6.25% | 0% |
| Cronobacter dublinensis | 0% | 0% | 2.56% | 0% |
| Cronobacter malonaticus | 0% | 0% | 1.82% | 0% |
| Cronobacter sakazakii | 0% | 5.13% | 0% | 0% |
| Edwardsiella tarda | 0% | 5.26% | 6.67% | 0% |
| Enterobacter asburiae | 0% | 0% | 5.14% | 0% |
| Enterobacter chengduensis | 0% | 100% | 16% | 0% |
| Enterobacter cloacae | 0% | 4.47% | 10.54% | 0% |
| Enterobacter hormaechei | 0.72% | 2.83% | 7.29% | 0% |
| Enterobacter kobei | 0% | 0.69% | 5.24% | 0% |
| Enterobacter roggenkampii | 0% | 2.42% | 6.83% | 0% |
| Escherichia albertii | 0% | 0.56% | 1.94% | 0% |
| Escherichia coli | 0.79% | 1.67% | 4.11% | 0.13% |
| Escherichia fergusonii | 1.64% | 1.78% | 15.22% | 0% |
| Escherichia marmotae | 0% | 3.12% | 0% | 0% |
| Klebsiella aerogenes | 2% | 3.26% | 7.06% | 0% |
| Klebsiella michiganensis | 0% | 4% | 4.79% | 0% |
| Klebsiella oxytoca | 0% | 0.68% | 0.42% | 0% |
| Klebsiella pneumoniae | 0.36% | 3.83% | 8.25% | 1.9% |
| Klebsiella quasipneumoniae | 0% | 3.81% | 15.66% | 0% |
| Leclercia adecarboxylata | 7.14% | 9.52% | 9.3% | 0% |
| Morganella morganii | 0% | 2.5% | 3.68% | 0% |
| Proteus mirabilis | 0.92% | 0% | 0.17% | 3.7% |
| Raoultella planticola | 0% | 6.98% | 2.56% | 0% |
| Salmonella enterica | 1.45% | 4.1% | 1.75% | 0.66% |
| Serratia liquefaciens | 0% | 16.67% | 0% | 0% |
| Serratia marcescens | 3.03% | 2.58% | 5.9% | 22.22% |
| Shigella boydii | 0% | 4.35% | 22.22% | 0% |
| Shigella dysenteriae | 0% | 0% | 6.67% | 0% |
| Shigella flexneri | 0% | 8.03% | 4.66% | 0% |
| Shigella sonnei | 0% | 4.85% | 2.41% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 400