Mycobacterium tuberculosis eccC5 conferring resistance to fluoroquinolones

Accession ARO:3004919
CARD Short NameMtub_eccC5_FLO
DefinitioneccC5 is a membrane-bound ATPase within the ESX-5 secretion system complex. The complex is critical for mycobacterium viability and virulence in the host cell and mutations contribute to a decreased uptake of antibiotic in the outer membrane, yet the Relational Sequencing Tuberculosis Data platform (ReSeqTB, finds no evidence of an association between eccC5 mutations and drug resistance.
AMR Gene Familyfluoroquinolone resistant eccC5
Drug Classfluoroquinolone antibiotic
Resistance Mechanismantibiotic target alteration
Classification10 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ fluoroquinolone resistant eccC5 [AMR Gene Family]
+ confers_resistance_to_antibiotic ofloxacin [Antibiotic]
+ confers_resistance_to_antibiotic moxifloxacin [Antibiotic]

Ezewudo M, et al. 2018. Sci Rep 8(1):15382 Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase. (PMID 30337678)

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