ofloxacin [Antibiotic]

Download Sequences


Accession ARO:3000663
Synonym(s)floxin Tarivid
DefinitionOfloxacin is a 6-fluoro, 7-piperazinyl quinolone with a methyl-substituted oxazine ring. It has a broad spectrum of activity including many enterobacteria and mycoplasma but most anaerobes are resistant.
Drug Classfluoroquinolone antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
29 ontology terms | Show
+ fluoroquinolone sensitive parC targeted_by_antibiotic
+ fluoroquinolone sensitive gyrA targeted_by_antibiotic
+ MexXY-OprM confers_resistance_to_antibiotic
+ Bartonella bacilliformis gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Escherichia coli gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Mycobaterium leprae gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Staphylococcus aureus gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Morganella morganii gyrB conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Mycobacterium leprae gyrB conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Salmonella serovars gyrB conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Ureaplasma urealyticum gyrB conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Escherichia coli parC conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Mycoplasma hominis parC conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Staphylococcus aureus parC conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Streptococcus pneumoniae parC conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Ureaplasma urealyticum parC conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Escherichia coli parE conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Salmonella serovars parE conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Staphylococcus aureus parE conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis gyrB mutant conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ Pseudomonas aeruginosa gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Acinetobacter baumannii gyrA conferring resistance to fluoroquinolones confers_resistance_to_antibiotic
+ Acinetobacter baumannii parC conferring resistance to fluoroquinolone confers_resistance_to_antibiotic
+ MexCD-OprJ with type A NfxB mutation confers_resistance_to_antibiotic
+ MexCD-OprJ with type B NfxB mutation confers_resistance_to_antibiotic
+ Staphylococcus aureus norA confers_resistance_to_antibiotic
+ MexXY-OprA confers_resistance_to_antibiotic
+ abeM confers_resistance_to_antibiotic
Publications

Sato K, et al. 1987. Infection 14(SUPPL 4): S226-S230. Antibacterial activity of ofloxacin and its mode of action. (PMID 3028966)

Mandell L and Tillotson G. 2002. Can J Infect Dis 13(1): 54-61. Safety of fluoroquinolones: An update. (PMID 18159374)

Nicolau D, et al. 1992. Conn Med 56(5): 261-263. Ofloxacin vs ciprofloxacin: a comparison. (PMID 1611900)