| Accession | ARO:3003032 |
| CARD Short Name | MexXY-OprM |
| Definition | MexXY-OprM is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexY is the membrane fusion protein; MexX is the RND-type membrane protein; and OprM is the outer membrane channel. MexXY-OprM is associated with resistance to acriflavine, erythromycin, norfloxacin and ofloxacin. The efflux system may also be involved in acquisition of higher resistance, in particular when bacteria are repeatedly exposed to subinhibitory doses of AGs. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | aminoglycoside antibiotic, disinfecting agents and antiseptics, phenicol antibiotic, tetracycline antibiotic, carbapenem, fluoroquinolone antibiotic, macrolide antibiotic, cephalosporin, cephamycin, penam |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Classification | 17 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + antibiotic mixture + beta-lactam antibiotic + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + aminoglycoside antibiotic [Drug Class] + gentamicin [Antibiotic] + disinfecting agents and antiseptics [Drug Class] + phenicol antibiotic [Drug Class] + cephem + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + tetracycline antibiotic [Drug Class] + carbapenem [Drug Class] + fluoroquinolone antibiotic [Drug Class] + macrolide antibiotic [Drug Class] |
| Parent Term(s) | 18 ontology terms | Show + confers_resistance_to_drug_class macrolide antibiotic [Drug Class] + confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class] + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_antibiotic amikacin [Antibiotic] + confers_resistance_to_antibiotic gentamicin C [Antibiotic] + confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class] + confers_resistance_to_drug_class cephalosporin [Drug Class] + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] + confers_resistance_to_drug_class cephamycin [Drug Class] + confers_resistance_to_antibiotic acriflavine [Antibiotic] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + confers_resistance_to_antibiotic tobramycin [Antibiotic] + confers_resistance_to_antibiotic meropenem [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_drug_class penam [Drug Class] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic norfloxacin [Antibiotic] + confers_resistance_to_antibiotic ofloxacin [Antibiotic] |
| Sub-Term(s) | 5 ontology terms | Show |
| Publications | Mine T, et al. 1999. Antimicrob Agents Chemother 43(2): 415-417. Expression in Escherichia coli of a new multidrug efflux pump, MexXY, from Pseudomonas aeruginosa. (PMID 9925549) Hocquet D, et al. 2003. Antimicrob. Agents Chemother. 47(4):1371-5 MexXY-OprM efflux pump is necessary for a adaptive resistance of Pseudomonas aeruginosa to aminoglycosides. (PMID 12654672) |
Prevalence of MexXY-OprM among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Name: MexXY-OprM
Model Description: MexXY-OprM is a multidrug efflux protein expressed in Pseudomonas aeruginosa. MexY is the membrane fusion protein; MexX is the RND-type membrane protein; and OprM is the outer membrane channel. MexXY-OprM is associated with resistance to acriflavine, erythromycin, norfloxacin and ofloxacin. The efflux system may also be involved in acquisition of higher resistance, in particular when bacteria are repeatedly exposed to subinhibitory doses of AGs.
OprMmexXmexYMexZModel Name: MexXY
Model Description: MexXY requires an outer membrane protein to function, however, it is unclear which outer membrane protein it is most commonly associated with. This model has been created to detect MexXY and the repressor MexZ, leaving the outer membrane protein to be variable.
mexXmexYMexZ