aminoglycoside antibiotic [Drug Class]

Accession ARO:0000016
DefinitionAminoglycosides are a group of antibiotics that are mostly effective against Gram-negative bacteria. These molecules consist of aminated sugars attached to a dibasic cyclitol. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth.
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
69 ontology terms | Show
+ astromicin [Antibiotic]
+ neomycin [Antibiotic]
+ dibekacin [Antibiotic]
+ amikacin [Antibiotic]
+ gentamicin C [Antibiotic]
+ ribostamycin [Antibiotic]
+ butirosin [Antibiotic]
+ sisomicin [Antibiotic]
+ apramycin [Antibiotic]
+ netilmicin [Antibiotic]
+ spectinomycin [Antibiotic]
+ streptomycin [Antibiotic]
+ kanamycin A [Antibiotic]
+ tobramycin [Antibiotic]
+ hygromycin B [Antibiotic]
+ isepamicin [Antibiotic]
+ G418 [Antibiotic]
+ arbekacin [Antibiotic]
+ gentamicin B [Antibiotic]
+ paromomycin [Antibiotic]
+ lividomycin
+ lividomycin A [Antibiotic]
+ verdamicin [Antibiotic]
+ vertilimicin [Antibiotic]
+ kasugamycin [Antibiotic]
+ lividomycin B [Antibiotic]
+ plazomicin [Antibiotic]
+ capreomycin [Antibiotic]
+ gentamicin A [Antibiotic]
+ determinant of aminoglycoside resistance confers_resistance_to_drug_class
+ Klebsiella pneumoniae KpnGH-TolC confers_resistance_to_drug_class
+ antibiotic resistant rpsL [AMR Gene Family] confers_resistance_to_drug_class
+ antibiotic resistant gidB [AMR Gene Family] confers_resistance_to_drug_class
+ Antibiotic resistant tlyA [AMR Gene Family] confers_resistance_to_drug_class
+ 16s rRNA with mutation conferring resistance to aminoglycoside antibiotics [AMR Gene Family] confers_resistance_to_drug_class
+ MexXY-OprA confers_resistance_to_drug_class
+ MexXY-OprM confers_resistance_to_drug_class
+ acrD confers_resistance_to_drug_class
+ AmrAB-OprM confers_resistance_to_drug_class
+ CeoAB-OpcM confers_resistance_to_drug_class
+ SmeABC confers_resistance_to_drug_class
+ AxyXY-OprZ confers_resistance_to_drug_class
+ cpa acetyltransferase [AMR Gene Family] confers_resistance_to_drug_class
+ amp acetyltransferase [AMR Gene Family] confers_resistance_to_drug_class
+ AAC(1) [AMR Gene Family] confers_resistance_to_drug_class
+ APH(3') [AMR Gene Family] confers_resistance_to_drug_class
+ APH(3'') [AMR Gene Family] confers_resistance_to_drug_class
+ APH(2'') [AMR Gene Family] confers_resistance_to_drug_class
+ APH(6) [AMR Gene Family] confers_resistance_to_drug_class
+ APH(9) [AMR Gene Family] confers_resistance_to_drug_class
+ APH(7'') [AMR Gene Family] confers_resistance_to_drug_class
+ APH(4) [AMR Gene Family] confers_resistance_to_drug_class
+ 16S rRNA methyltransferase (G1405) [AMR Gene Family] confers_resistance_to_drug_class
+ 16S rRNA methyltransferase (A1408) [AMR Gene Family] confers_resistance_to_drug_class
+ ANT(3'') [AMR Gene Family] confers_resistance_to_drug_class
+ ANT(2'') [AMR Gene Family] confers_resistance_to_drug_class
+ MipA-interacting Protein [AMR Gene Family] confers_resistance_to_drug_class
+ phenotypic variant regulator [AMR Gene Family] confers_resistance_to_drug_class
+ ANT(9) [AMR Gene Family] confers_resistance_to_drug_class
+ AAC(6') [AMR Gene Family] confers_resistance_to_drug_class
+ AAC(2') [AMR Gene Family] confers_resistance_to_drug_class
+ ANT(6) [AMR Gene Family] confers_resistance_to_drug_class
+ AAC(3) [AMR Gene Family] confers_resistance_to_drug_class
+ ANT(4') [AMR Gene Family] confers_resistance_to_drug_class
+ kdpDE [AMR Gene Family] confers_resistance_to_drug_class
+ LAP beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ antibiotic sensitive 16S rRNA targeted_by
+ antibiotic sensitive Ribosomal protein S12 (rpsL) targeted_by
+ antibiotic sensitive gidB targeted_by
Publications

Kotra LP, et al. 2000. Antimicrob Agents Chemother 44(12): 3249-3256. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance. (PMID 11083623)

Mingeot-Leclercq MP, et al. 1999. Antimicrob Agents Chemother 43(4): 727-737. Aminoglycosides: activity and resistance. (PMID 10103173)

Shaw KJ, et al. 1993. Microbiol Rev 57(1): 138-163. Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. (PMID 8385262)