Accession ARO:3004141
DefinitionAn RND-type efflux system that confers innate aminoglycoside resistance to Achromobacter spp. It has a transcriptional regulator encoded by the axyZ gene located upstream of axyXY-oprZ. In-frame axyZ gene deletion assay led to increased MICs of antibiotic substrates of the efflux system: aminoglycosides, cefepime, fluoroquinolones, tetracyclines and erythromycin, indicating that the product of axyZ negatively regulates expression of axyXY-oprZ. Moreover a 45 amino-acid substitution at position 29 of AxyZ (V29G) was identified in a clinical Achromobacter strain that occurred during the course of chronic respiratory tract colonization in a cystic fibrosis (CF) patient. This substitution, also detected in 3 other strains exposed in vitro to tobramycin, led to the increase in axyY transcription level (5 to 17-fold) together with the increase in antibiotic resistance level.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, triclosan, macrolide antibiotic, aminocoumarin antibiotic, antibacterial free fatty acids, carbapenem, aminoglycoside antibiotic, phenicol antibiotic, penam, fluoroquinolone antibiotic, diaminopyrimidine antibiotic, glycylcycline, cephalosporin, acridine dye, monobactam
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification24 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
+ confers_resistance_to_antibiotic erythromycin [Antibiotic]
+ confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class]
+ confers_resistance_to_antibiotic cefepime [Antibiotic]
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
4 ontology terms | Show
+ OprZ part_of
+ AxyX part_of
+ AxyY part_of
+ AxyZ part_of

Bador J, et al. 2017. Antimicrob. Agents Chemother. : The role of AxyZ transcriptional regulator in the overproduction of AxyXY-OprZ multidrug efflux system in Achromobacter spp. mutants selected by tobramycin. (PMID 28584156)