| Accession | ARO:3004141 |
| Definition | An RND-type efflux system that confers innate aminoglycoside resistance to Achromobacter spp. It has a transcriptional regulator encoded by the axyZ gene located upstream of axyXY-oprZ. In-frame axyZ gene deletion assay led to increased MICs of antibiotic substrates of the efflux system: aminoglycosides, cefepime, fluoroquinolones, tetracyclines and erythromycin, indicating that the product of axyZ negatively regulates expression of axyXY-oprZ. Moreover a 45 amino-acid substitution at position 29 of AxyZ (V29G) was identified in a clinical Achromobacter strain that occurred during the course of chronic respiratory tract colonization in a cystic fibrosis (CF) patient. This substitution, also detected in 3 other strains exposed in vitro to tobramycin, led to the increase in axyY transcription level (5 to 17-fold) together with the increase in antibiotic resistance level. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | cephalosporin, macrolide antibiotic, fluoroquinolone antibiotic, aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Classification | 10 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + beta-lactam antibiotic + mechanism of antibiotic resistance + cephem + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + cephalosporin [Drug Class] + macrolide antibiotic [Drug Class] |
| Parent Term(s) | 5 ontology terms | Show + confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class] + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_drug_class aminoglycoside antibiotic [Drug Class] + confers_resistance_to_antibiotic cefepime [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] |
| Sub-Term(s) | 4 ontology terms | Show |
| Publications | Bador J, et al. 2017. Antimicrob. Agents Chemother. : The role of AxyZ transcriptional regulator in the overproduction of AxyXY-OprZ multidrug efflux system in Achromobacter spp. mutants selected by tobramycin. (PMID 28584156) |