AxyY

Accession ARO:3004144
DefinitionAxyY is the periplasmic adaptor protein of the AxyXY-OprZ efflux pump system in Achromobacter spp.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classmacrolide antibiotic, cephalosporin, aminoglycoside antibiotic, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification15 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Bador J, et al. 2017. Antimicrob. Agents Chemother. : The role of AxyZ transcriptional regulator in the overproduction of AxyXY-OprZ multidrug efflux system in Achromobacter spp. mutants selected by tobramycin. (PMID 28584156)

Resistomes

Prevalence of AxyY among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
Achromobacter xylosoxidans100%0%68.49%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 1700


>gb|EGP45231.1|-|AxyY [Achromobacter insuavis AXX-A]
MARFFIDRPVFAWVISLLIALVGLLSIRALPVAQYPDIAPPVVNIGASYPGASAKVVEEAVTAIIEREMNGAPGLMYTSSSSDSTGWASI
NLTFKQGTNPDIAAVEVQNRLKAVEPRLPESVRRDGVRVEKAADNIQLVVSLKSDGSLDDMQLGELAASNVLQALRRVEGVGKVQSFGAE
AAMRIWPDPAKLTALSLTPGDIVSALRSHNARVTIGELGNQAVPKDAPLNASIVAGESLHTPEQFANIPLRALPDGATLRLKDVARVELG
GTDYMYLSRVNGLTGTGLGIKLAPGSNAVETTRRIRETMRELAQYFPPGVTWDIPYETSTFVEISIKKVLMTLLEAVALVFCVMYLFMQN
LRATLIPTLVVPVALLGTLGVMLGLGYSINVLTMFGMVLAIGILVDDAIVVVENVERIMAEEGLSPHDATVKAMGQISGAIVGITVVLVS
VFVPMAFFDGAVGNIYRQFAVTLAVSIAFSAFLALSLTPALCASLLKPVPAGHHEKRGFFGWFNRAFARLTTRYTARVAGVLARPVRFGL
AYALVIGVAALLFARLPSSFLPDEDQGSFMAMVILPQGSPQAETMAVVKDVERYMMEHEPVQYVYSVNGFSQYGSGPNSAMFFVTLKDWK
ERRDASQHVDAVVKRINKAFADRKNLMVFALNSPPLPDLGSTSGFDFRLQDRGGLGYEALTQARQKLLAKAAEHPALTDVVFAGQEEAPQ
LQLRVDRDKAQAMGVPIDEINTALAVMYGSDYIGDFMLNGQVRRVMVQADGKRRVDVDDISRLHVRNLQGQMVPLSAFATLTWSMGPPQL
NRYNGFPSFTINGSAARGHSSGEAMRAMETLAAELPRGIGFDWSGQSYEERLSGNQAPVLFALSVLIVFLALAALYESWSIPLAVILVVP
LGVIGALLGVTVRGMPNDIYFKVGLIATIGLSAKNAILIVEVAKDLVRDGQGILSATLEAARLRLRPIVMTSLAFGVGVLPLALATGAAS
GAQAAIGTGVLGGIITATVLAVFLVPLFFLIVGRMVGMRARPARPDGREPLETTP


>gb|AFRQ01000061.1|-|23987-27124|AxyY [Achromobacter insuavis AXX-A]
ATGGCGCGTTTCTTTATCGATCGCCCCGTTTTCGCGTGGGTGATCTCGCTGCTCATCGCGCTGGTCGGCCTGTTGTCGATCCGCGCGCTG
CCGGTGGCGCAGTATCCGGACATCGCTCCGCCCGTCGTCAACATCGGCGCCAGCTATCCCGGCGCCTCGGCCAAGGTGGTCGAGGAAGCC
GTCACCGCCATCATCGAACGCGAGATGAACGGCGCCCCGGGCCTGATGTACACCTCGTCCAGCAGCGATTCGACCGGCTGGGCCAGCATC
AACCTGACCTTCAAGCAGGGCACCAACCCCGACATCGCGGCGGTGGAAGTGCAGAACCGCCTGAAGGCGGTCGAGCCTCGCCTGCCCGAA
TCGGTGCGGCGCGATGGCGTGCGCGTGGAAAAGGCGGCCGACAACATCCAGCTGGTGGTGTCGTTGAAGTCGGACGGCAGCCTGGACGAC
ATGCAACTGGGCGAGCTGGCCGCCTCCAATGTGCTGCAGGCGCTGCGGCGGGTCGAAGGCGTGGGCAAGGTGCAGTCGTTCGGCGCGGAA
GCGGCGATGCGCATCTGGCCGGACCCGGCCAAGCTCACCGCCCTGTCGCTGACGCCGGGCGACATCGTCTCGGCGCTGCGCAGCCACAAC
GCGCGCGTCACCATCGGCGAACTGGGCAACCAGGCCGTGCCCAAGGACGCGCCGCTGAACGCCAGCATCGTGGCGGGCGAATCGCTGCAC
ACGCCGGAACAGTTCGCCAACATCCCGCTGCGGGCGCTGCCGGACGGCGCCACGCTGCGCCTGAAGGACGTGGCGCGGGTGGAGCTGGGC
GGCACCGACTACATGTACCTGTCGCGCGTCAACGGCCTGACCGGCACCGGCCTGGGCATCAAGCTGGCGCCCGGCTCCAACGCCGTCGAA
ACCACCCGCCGCATCCGCGAGACCATGCGCGAGCTGGCGCAATACTTCCCGCCGGGCGTGACCTGGGACATTCCGTACGAGACCTCCACC
TTCGTCGAGATCTCGATCAAGAAGGTCCTGATGACGCTGCTGGAGGCGGTGGCGCTGGTGTTCTGCGTGATGTACCTGTTCATGCAGAAC
CTGCGCGCCACGCTGATCCCGACCCTGGTGGTGCCGGTGGCGCTGCTGGGCACGCTGGGGGTGATGCTGGGGCTGGGCTATTCGATCAAC
GTGCTGACGATGTTCGGCATGGTGCTGGCCATCGGCATCCTGGTGGACGACGCCATCGTGGTGGTCGAGAACGTCGAGCGCATCATGGCC
GAGGAAGGCCTGTCGCCGCATGACGCCACGGTCAAGGCCATGGGCCAGATCAGCGGCGCCATCGTCGGCATCACCGTGGTGCTGGTGTCG
GTGTTCGTGCCGATGGCGTTCTTCGACGGCGCGGTGGGCAACATCTACCGCCAGTTCGCCGTGACGCTGGCGGTGTCGATCGCCTTCTCG
GCCTTCCTGGCGCTGTCGCTGACGCCGGCGCTGTGCGCCAGCCTGCTCAAACCCGTCCCGGCCGGCCACCACGAGAAGCGCGGCTTCTTC
GGCTGGTTCAACCGCGCCTTCGCGCGCCTGACCACGCGCTATACGGCGCGGGTGGCCGGCGTGCTGGCGCGGCCGGTACGCTTCGGCCTG
GCCTATGCGCTGGTGATCGGCGTGGCGGCGTTGCTGTTCGCGCGGCTGCCATCGTCGTTCCTGCCGGACGAGGACCAGGGCAGCTTCATG
GCCATGGTGATCCTGCCGCAGGGCTCGCCGCAGGCCGAGACCATGGCGGTGGTCAAGGACGTCGAACGCTACATGATGGAGCACGAGCCG
GTGCAGTACGTGTATTCGGTCAACGGCTTCAGCCAGTACGGCAGCGGCCCGAACTCCGCCATGTTCTTCGTCACGCTGAAGGACTGGAAG
GAACGCCGCGATGCCTCGCAACACGTGGACGCGGTGGTCAAGCGCATCAACAAGGCGTTCGCGGATCGCAAGAACCTGATGGTGTTCGCG
CTGAACTCGCCGCCGCTGCCTGACCTGGGCTCGACCTCGGGCTTCGACTTCCGGCTGCAGGATCGCGGCGGCCTCGGCTACGAAGCCCTG
ACGCAGGCGCGCCAGAAGCTGCTGGCCAAGGCGGCCGAGCATCCCGCGCTGACGGACGTGGTGTTCGCCGGCCAGGAAGAGGCGCCGCAG
CTGCAACTGCGCGTCGACCGCGACAAGGCGCAGGCCATGGGCGTGCCGATCGACGAGATCAACACCGCGCTGGCTGTGATGTACGGCTCG
GACTACATCGGCGACTTCATGCTCAACGGCCAGGTTCGGCGCGTGATGGTGCAGGCCGACGGCAAGCGCCGCGTGGACGTGGACGACATC
TCGCGCCTGCACGTGCGCAACCTGCAGGGCCAGATGGTGCCGCTGTCGGCGTTCGCCACGCTGACGTGGTCGATGGGGCCGCCGCAGCTG
AACCGCTACAACGGCTTCCCGTCGTTCACCATCAACGGCTCGGCGGCGCGCGGCCACAGCAGCGGCGAGGCCATGCGCGCCATGGAGACG
CTGGCGGCCGAGCTGCCGCGCGGCATCGGCTTCGACTGGTCGGGCCAATCGTACGAAGAGCGGCTGTCCGGCAACCAGGCGCCGGTGCTG
TTCGCGCTGTCGGTGCTGATCGTGTTCCTGGCGCTGGCGGCGCTGTATGAAAGCTGGTCGATTCCGCTGGCGGTGATCCTGGTGGTGCCG
CTGGGCGTGATCGGCGCGCTGCTGGGGGTGACCGTGCGCGGCATGCCCAACGACATCTACTTCAAGGTCGGCCTGATCGCCACCATCGGC
CTGTCCGCCAAGAACGCGATCCTGATCGTGGAAGTGGCCAAGGACCTGGTGCGCGACGGCCAGGGCATCCTGTCCGCCACGCTGGAAGCG
GCGCGGCTGCGGCTGCGGCCGATCGTGATGACCTCGCTGGCCTTTGGCGTGGGCGTGCTGCCGCTGGCGCTGGCCACTGGCGCCGCCTCG
GGCGCGCAGGCCGCCATCGGCACCGGCGTGCTGGGCGGGATCATCACGGCGACCGTGCTGGCGGTGTTCCTGGTGCCGCTGTTCTTTCTC
ATCGTGGGACGCATGGTCGGCATGCGCGCCCGCCCCGCGCGCCCCGACGGCCGCGAACCGCTGGAGACGACGCCATGA