erythromycin [Antibiotic]

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Accession ARO:0000006
Synonym(s)Abomacetin Emgel Eritromicina Erymax Erythrocin Erythromycin A Erythromycine Erythromycinum N-methylerythromycin A
DefinitionErythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.
SMILESCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
PubChem12560
ChEMBLCHEMBL532
ChEBI42355
Drug Classmacrolide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ macrolide antibiotic [Drug Class]
Sub-Term(s)
112 ontology terms | Show
+ EreA confers_resistance_to_antibiotic
+ EreB confers_resistance_to_antibiotic
+ mel confers_resistance_to_antibiotic
+ msrA confers_resistance_to_antibiotic
+ MacAB-TolC confers_resistance_to_antibiotic
+ CmeABC confers_resistance_to_antibiotic
+ MdtEF-TolC confers_resistance_to_antibiotic
+ Acinetobacter baumannii AmvA confers_resistance_to_antibiotic
+ MexAB-OprM confers_resistance_to_antibiotic
+ Clostridioides difficile 23S rRNA with mutation conferring resistance to erythromycin and clindamycin confers_resistance_to_antibiotic
+ ErmC confers_resistance_to_antibiotic
+ ErmE confers_resistance_to_antibiotic
+ ErmA confers_resistance_to_antibiotic
+ ErmB confers_resistance_to_antibiotic
+ Erm(37) confers_resistance_to_antibiotic
+ ErmD confers_resistance_to_antibiotic
+ ErmF confers_resistance_to_antibiotic
+ ErmG confers_resistance_to_antibiotic
+ ErmN confers_resistance_to_antibiotic
+ ErmQ confers_resistance_to_antibiotic
+ ErmR confers_resistance_to_antibiotic
+ ErmT confers_resistance_to_antibiotic
+ ErmX confers_resistance_to_antibiotic
+ Erm(33) confers_resistance_to_antibiotic
+ Erm(34) confers_resistance_to_antibiotic
+ Erm(38) confers_resistance_to_antibiotic
+ Erm(39) confers_resistance_to_antibiotic
+ Erm(41) confers_resistance_to_antibiotic
+ Erm(35) confers_resistance_to_antibiotic
+ Erm(36) confers_resistance_to_antibiotic
+ oleD confers_resistance_to_antibiotic
+ mgtA confers_resistance_to_antibiotic
+ mphA confers_resistance_to_antibiotic
+ mphB confers_resistance_to_antibiotic
+ mphC confers_resistance_to_antibiotic
+ MexVW-OprM confers_resistance_to_antibiotic
+ MexXY-OprM confers_resistance_to_antibiotic
+ MexJK-OprM confers_resistance_to_antibiotic
+ MexPQ-OpmE confers_resistance_to_antibiotic
+ EfrAB confers_resistance_to_antibiotic
+ efmA confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnGH-TolC confers_resistance_to_antibiotic
+ EreA2 confers_resistance_to_antibiotic
+ MexCD-OprJ with type A NfxB mutation confers_resistance_to_antibiotic
+ MexCD-OprJ with type B NfxB mutation confers_resistance_to_antibiotic
+ MuxABC-OpmB confers_resistance_to_antibiotic
+ MexAB-OprM with MexR mutations confers resistance to multiple antibiotics confers_resistance_to_antibiotic
+ LpeAB confers_resistance_to_antibiotic
+ Escherichia coli 23S rRNA with mutation conferring resistance to erythromycin and telithromycin confers_resistance_to_antibiotic
+ Chlamydomonas reinhardtii 23S rRNA with mutation conferring resistance to erythromycin confers_resistance_to_antibiotic
+ Escherichia coli emrE confers_resistance_to_antibiotic
+ AxyXY-OprZ confers_resistance_to_antibiotic
+ Mycoplasma pneumoniae 23S rRNA mutation conferring resistance to erythromycin confers_resistance_to_antibiotic
+ Campylobacter jejuni 23S rRNA with mutation conferring resistance to erythromycin confers_resistance_to_antibiotic
+ Staphylococcus aureus LmrS confers_resistance_to_antibiotic
+ MexXY-OprA confers_resistance_to_antibiotic
+ abeS confers_resistance_to_antibiotic
+ MtrCDE confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnEF confers_resistance_to_antibiotic
+ hp1184 confers_resistance_to_antibiotic
+ Neisseria gonorrhoeae mtrR with mutation conferring resistance confers_resistance_to_antibiotic
+ msrB confers_resistance_to_antibiotic
+ msrC confers_resistance_to_antibiotic
+ msrE confers_resistance_to_antibiotic
+ EreD confers_resistance_to_antibiotic
+ Erm(42) confers_resistance_to_antibiotic
+ Erm(43) confers_resistance_to_antibiotic
+ Erm(44)v confers_resistance_to_antibiotic
+ Erm(47) confers_resistance_to_antibiotic
+ Erm(48) confers_resistance_to_antibiotic
+ Erm(49) confers_resistance_to_antibiotic
+ Erm(51) confers_resistance_to_antibiotic
+ Erm(K) confers_resistance_to_antibiotic
+ Erm(O)-lrm confers_resistance_to_antibiotic
+ ErmH confers_resistance_to_antibiotic
+ ErmV confers_resistance_to_antibiotic
+ ErmW confers_resistance_to_antibiotic
+ ErmY confers_resistance_to_antibiotic
+ Chlamydia trachomatis 23S rRNA with mutation conferring resistance to macrolide antibiotics confers_resistance_to_antibiotic
+ Moraxella catarrhalis 23S rRNA with mutation conferring resistance to macrolide antibiotics confers_resistance_to_antibiotic
+ Mycoplasma hominis 23S rRNA with mutation conferring resistance to macrolide antibiotics confers_resistance_to_antibiotic
+ Mycoplasmopsis fermentans 23S rRNA with mutation conferring resistance to macrolide antibiotics confers_resistance_to_antibiotic
+ Propionibacteria 23S rRNA with mutation conferring resistance to macrolide antibiotics confers_resistance_to_antibiotic
+ Streptococcus pneumoniae 23S rRNA with mutation conferring resistance to macrolide antibiotics confers_resistance_to_antibiotic
+ erm(40) confers_resistance_to_antibiotic
+ erm(45) confers_resistance_to_antibiotic
+ erm(46) confers_resistance_to_antibiotic
+ mphJ confers_resistance_to_antibiotic
+ mphE confers_resistance_to_antibiotic
+ mphF confers_resistance_to_antibiotic
+ mphG confers_resistance_to_antibiotic
+ mphI confers_resistance_to_antibiotic
+ mphL confers_resistance_to_antibiotic
+ mphM confers_resistance_to_antibiotic
+ mphN confers_resistance_to_antibiotic
+ mphO confers_resistance_to_antibiotic
+ msr(G) confers_resistance_to_antibiotic
+ msrF confers_resistance_to_antibiotic
+ msrH confers_resistance_to_antibiotic
+ 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) confers_resistance_to_antibiotic
+ Enterobacter cloacae rob confers_resistance_to_antibiotic
+ Mrx confers_resistance_to_antibiotic
+ lmrP confers_resistance_to_antibiotic
+ mef(B) confers_resistance_to_antibiotic
+ mef(D) confers_resistance_to_antibiotic
+ mef(E) confers_resistance_to_antibiotic
+ mef(F) confers_resistance_to_antibiotic
+ mreA confers_resistance_to_antibiotic
+ erm(56) confers_resistance_to_antibiotic
+ aadT confers_resistance_to_antibiotic
+ Treponema pallidum 23S rRNA with mutation conferring resistance to erythromycin confers_resistance_to_antibiotic
+ 50S ribosomal subunit P-site targeted_by_antibiotic
Publications

Gibreel A, et al. 2005. Antimicrob Agents Chemother 49(7): 2753-2759. Macrolide resistance in Campylobacter jejuni and Campylobacter coli: molecular mechanism and stability of the resistance phenotype. (PMID 15980346)

Roberts MC, et al. 1999. Antimicrob Agents Chemother 43(12): 2823-2830. Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants. (PMID 10582867)

Mazzei T, et al. 1993. J Antimicrob Chemother 31(SUPPL C): 1-9. Chemistry and mode of action of macrolides. (PMID 7683018)
Curator Acknowledgements
Curator Description Most Recent Edit