| Accession | ARO:3003839 |
| CARD Short Name | Mrx |
| Definition | Mrx is part of the macrolide inactivation gene cluster in Aeromonas hydrophila. |
| AMR Gene Family | macrolide phosphotransferase (MPH) |
| Drug Class | macrolide antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter baumanniiwgs, Aeromonas caviaeg+p+wgs, Aeromonas hydrophilag+p+wgs, Aeromonas veroniig+p+wgs, Alcaligenes faecalisp, Bordetella trematumg, Citrobacter amalonaticusp+wgs, Citrobacter freundiip+wgs, Citrobacter koserig+p+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniiwgs, Citrobacter youngaep+wgs, Comamonas testosteronip, Cronobacter malonaticuswgs, Cronobacter sakazakiip, Enterobacter asburiaep+wgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia albertiip+wgs, Escherichia colig+p+wgs, Escherichia fergusoniip+wgs, Klebsiella aerogenesg+p+wgs, Klebsiella michiganensisg+p+wgs, Klebsiella oxytocap+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatag+p+wgs, Morganella morganiig+p+wgs, Proteus mirabilisg+p+wgs, Providencia rettgerig+wgs, Providencia stuartiip+wgs, Pseudomonas aeruginosag+p+wgs, Pseudomonas putidawgs, Raoultella planticolap+wgs, Salmonella entericag+p+wgs, Serratia marcescensp+wgs, Shewanella putrefaciensp, Shigella boydiiwgs, Shigella dysenteriaewgs, Shigella flexnerig+p+wgs, Shigella sonneig+p+wgs, Streptococcus suiswgs, Vibrio alginolyticuswgs, Vibrio choleraeg+p+wgs, Vibrio fluvialiswgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Aeromonas caviaeg+p+wgs, Aeromonas hydrophilag+p+wgs, Aeromonas veroniig+p+wgs, Alcaligenes faecalisp, Bordetella trematumg, Citrobacter amalonaticusp+wgs, Citrobacter freundiig+p+wgs, Citrobacter koserig+p+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniiwgs, Citrobacter youngaep+wgs, Comamonas testosteronip, Cronobacter malonaticuswgs, Cronobacter sakazakiip, Enterobacter asburiaep+wgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia albertiip+wgs, Escherichia colig+p+wgs, Escherichia fergusoniip+wgs, Klebsiella aerogenesg+p+wgs, Klebsiella michiganensisg+p+wgs, Klebsiella oxytocap+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatag+p+wgs, Morganella morganiig+p+wgs, Proteus mirabilisg+p+wgs, Providencia rettgerig+wgs, Providencia stuartiip+wgs, Pseudomonas aeruginosag+p+wgs, Pseudomonas putidawgs, Raoultella planticolap+wgs, Salmonella entericag+p+wgs, Serratia marcescensp+wgs, Shewanella putrefaciensp, Shigella boydiiwgs, Shigella dysenteriaewgs, Shigella flexnerig+p+wgs, Shigella sonneig+p+wgs, Streptococcus suiswgs, Vibrio alginolyticuswgs, Vibrio choleraeg+p+wgs, Vibrio fluvialiswgs |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic molecule + antibiotic inactivation enzyme + macrolide antibiotic [Drug Class] + macrolide inactivation enzyme + phosphorylation of antibiotic conferring resistance |
| Parent Term(s) | 4 ontology terms | Show + macrolide phosphotransferase (MPH) [AMR Gene Family] + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_antibiotic azithromycin [Antibiotic] + confers_resistance_to_antibiotic tylosin [Antibiotic] |
| Publications | Poole TL, et al. 2005. J Antimicrob Chemother 57(1): 31-38. Macrolide inactivation gene cluster mphA-mrx-mphR adjacent to a class 1 integron in Aeromonas hydrophila isolated from a diarrhoeic pig in Oklahoma. (PMID 16339607) |
Prevalence of Mrx among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.01% | 0% |
| Aeromonas caviae | 25% | 7.79% | 10.22% | 0% |
| Aeromonas hydrophila | 10.77% | 5.19% | 6.45% | 0% |
| Aeromonas veronii | 10.91% | 4.62% | 4.49% | 0% |
| Alcaligenes faecalis | 0% | 20% | 0% | 0% |
| Bordetella trematum | 20% | 0% | 0% | 0% |
| Citrobacter amalonaticus | 0% | 25% | 1.82% | 0% |
| Citrobacter freundii | 0.82% | 9.85% | 16.63% | 0% |
| Citrobacter koseri | 6.25% | 15% | 3.6% | 0% |
| Citrobacter portucalensis | 0% | 25% | 24.32% | 0% |
| Citrobacter werkmanii | 0% | 0% | 17.95% | 0% |
| Citrobacter youngae | 0% | 9.09% | 12.5% | 0% |
| Comamonas testosteroni | 0% | 50% | 0% | 0% |
| Cronobacter malonaticus | 0% | 0% | 1.82% | 0% |
| Cronobacter sakazakii | 0% | 2.56% | 0% | 0% |
| Enterobacter asburiae | 0% | 0.83% | 3.16% | 0% |
| Enterobacter cloacae | 0% | 1.68% | 9.58% | 0% |
| Enterobacter hormaechei | 0% | 3.93% | 7.98% | 0% |
| Enterobacter kobei | 0% | 1.38% | 6.99% | 0% |
| Enterobacter roggenkampii | 0% | 0.48% | 1.8% | 0% |
| Escherichia albertii | 0% | 0.56% | 0.65% | 0% |
| Escherichia coli | 1.98% | 4.24% | 10.32% | 0% |
| Escherichia fergusonii | 0% | 1.07% | 6.52% | 0% |
| Klebsiella aerogenes | 2% | 5.43% | 2.82% | 0% |
| Klebsiella michiganensis | 9.68% | 12.57% | 7.18% | 0% |
| Klebsiella oxytoca | 0% | 2.74% | 4.62% | 0% |
| Klebsiella pneumoniae | 1.07% | 5.28% | 17.3% | 0% |
| Klebsiella quasipneumoniae | 0% | 2.54% | 8.95% | 0% |
| Leclercia adecarboxylata | 7.14% | 4.76% | 2.33% | 0% |
| Morganella morganii | 17.31% | 10% | 7.36% | 0% |
| Proteus mirabilis | 5.5% | 6.25% | 1.82% | 0% |
| Providencia rettgeri | 5.88% | 0% | 2.55% | 0% |
| Providencia stuartii | 0% | 2.27% | 2.27% | 0% |
| Pseudomonas aeruginosa | 0.46% | 0.29% | 0.19% | 0% |
| Pseudomonas putida | 0% | 0% | 1.6% | 0% |
| Raoultella planticola | 0% | 11.63% | 15.38% | 0% |
| Salmonella enterica | 1.7% | 3.17% | 1.05% | 0% |
| Serratia marcescens | 0% | 1.29% | 0.39% | 0% |
| Shewanella putrefaciens | 0% | 40% | 0% | 0% |
| Shigella boydii | 0% | 0% | 11.11% | 0% |
| Shigella dysenteriae | 0% | 0% | 3.33% | 0% |
| Shigella flexneri | 3% | 7.63% | 12.27% | 0% |
| Shigella sonnei | 2.44% | 5.83% | 3.8% | 0% |
| Streptococcus suis | 0% | 0% | 0.05% | 0% |
| Vibrio alginolyticus | 0% | 0% | 0.4% | 0% |
| Vibrio cholerae | 0.45% | 10.53% | 0.89% | 0% |
| Vibrio fluvialis | 0% | 0% | 4% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 600