azithromycin [Antibiotic]

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Accession ARO:3000158
DefinitionAzithromycin is a 15-membered macrolide and falls under the subclass of azalide. Like other macrolides, azithromycin binds bacterial ribosomes to inhibit protein synthesis. The nitrogen substitution at the C-9a position prevents its degradation.
Drug Classmacrolide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ macrolide antibiotic [Drug Class]
36 ontology terms | Show
+ EreB confers_resistance_to_antibiotic
+ MexAB-OprM confers_resistance_to_antibiotic
+ ErmC confers_resistance_to_antibiotic
+ ErmE confers_resistance_to_antibiotic
+ ErmA confers_resistance_to_antibiotic
+ ErmB confers_resistance_to_antibiotic
+ Erm(37) confers_resistance_to_antibiotic
+ ErmD confers_resistance_to_antibiotic
+ ErmF confers_resistance_to_antibiotic
+ ErmG confers_resistance_to_antibiotic
+ ErmN confers_resistance_to_antibiotic
+ ErmQ confers_resistance_to_antibiotic
+ ErmR confers_resistance_to_antibiotic
+ ErmT confers_resistance_to_antibiotic
+ ErmX confers_resistance_to_antibiotic
+ Erm(31) confers_resistance_to_antibiotic
+ Erm(33) confers_resistance_to_antibiotic
+ Erm(34) confers_resistance_to_antibiotic
+ Erm(38) confers_resistance_to_antibiotic
+ Erm(39) confers_resistance_to_antibiotic
+ Erm(41) confers_resistance_to_antibiotic
+ Erm(35) confers_resistance_to_antibiotic
+ Erm(36) confers_resistance_to_antibiotic
+ mgtA confers_resistance_to_antibiotic
+ mphA confers_resistance_to_antibiotic
+ mphB confers_resistance_to_antibiotic
+ mphC confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnGH-TolC confers_resistance_to_antibiotic
+ MexAB-OprM with MexR mutations confers resistance to multiple antibiotics confers_resistance_to_antibiotic
+ LpeAB confers_resistance_to_antibiotic
+ Mycobacterium intracellulare 23S rRNA with mutation conferring resistance to azithromycin confers_resistance_to_antibiotic
+ MtrCDE confers_resistance_to_antibiotic
+ Neisseria gonorrhoeae mtrR with mutation conferring resistance confers_resistance_to_antibiotic
+ Neisseria gonorrhoeae rpld confers_resistance_to_antibiotic
+ Neisseria gonorrhoeae 23S rRNA with mutation conferring resistance to azithromycin confers_resistance_to_antibiotic
+ 50S ribosomal subunit P-site targeted_by_antibiotic

Williams JD. 1991. Eur J Clin Microbiol Infect Dis 10(10): 813-820. Spectrum of activity of azithromycin. (PMID 1662624)