| Accession | ARO:3000386 |
| Definition | MexAB-OprM is a multidrug efflux protein expressed in the Gram-negative Pseudomonas aeruginosa. MexA is the membrane fusion protein; MexB is the inner membrane transporter; and OprM is the outer membrane channel. MexAB-OprM is associated with resistance to fluoroquinolones, chloramphenicol, erythromycin, azithromycin, novobiocin, and certain β-lactams and lastly over-expression is linked to colistin resistance. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | peptide antibiotic, sulfonamide antibiotic, diaminopyrimidine antibiotic, phenicol antibiotic, aminocoumarin antibiotic, tetracycline antibiotic, penam, cephalosporin, carbapenem, monobactam, fluoroquinolone antibiotic, macrolide antibiotic, cephamycin, penem |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Classification | 26 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + peptide antibiotic [Drug Class] + lipopeptide antibiotic + beta-lactam antibiotic + mechanism of antibiotic resistance + sulfonamide antibiotic [Drug Class] + cephem + diaminopyrimidine antibiotic [Drug Class] + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + polymyxin antibiotic + antibiotic mixture + phenicol antibiotic [Drug Class] + sulfamethoxazole [Antibiotic] + trimethoprim [Antibiotic] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + aminocoumarin antibiotic [Drug Class] + tetracycline antibiotic [Drug Class] + penam [Drug Class] + colistin + cephalosporin [Drug Class] + carbapenem [Drug Class] + monobactam [Drug Class] + fluoroquinolone antibiotic [Drug Class] + macrolide antibiotic [Drug Class] |
| Parent Term(s) | 24 ontology terms | Show + confers_resistance_to_drug_class macrolide antibiotic [Drug Class] + confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class] + confers_resistance_to_antibiotic erythromycin [Antibiotic] + confers_resistance_to_drug_class cephalosporin [Drug Class] + confers_resistance_to_antibiotic ciprofloxacin [Antibiotic] + confers_resistance_to_drug_class cephamycin [Drug Class] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + confers_resistance_to_antibiotic ceftazidime [Antibiotic] + confers_resistance_to_antibiotic ceftriaxone [Antibiotic] + confers_resistance_to_antibiotic meropenem [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_drug_class penam [Drug Class] + confers_resistance_to_antibiotic novobiocin [Antibiotic] + confers_resistance_to_antibiotic azithromycin [Antibiotic] + confers_resistance_to_antibiotic trimethoprim [Antibiotic] + confers_resistance_to_drug_class sulfonamide antibiotic [Drug Class] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic aztreonam [Antibiotic] + confers_resistance_to_antibiotic colistin A [Antibiotic] + confers_resistance_to_antibiotic colistin B [Antibiotic] + confers_resistance_to_antibiotic ampicillin [Antibiotic] + confers_resistance_to_drug_class penem [Drug Class] + confers_resistance_to_antibiotic panipenem [Antibiotic] + confers_resistance_to_antibiotic trimethoprim-sulfamethoxazole [Antibiotic] |
| Sub-Term(s) | 13 ontology terms | Show + MexA part_of + MexB part_of + OprM part_of + MexR regulates + nalC regulates + nalD regulates + CpxR regulates + ArmR regulates + MexAB-OprM with prematurely terminated MexR conferring resistance to meropenem and ciprofloxacin + MexAB-OprM with NalC mutations conferring resistance to aztreonam + MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics + MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam + MexAB-OprM with MexR mutations confers resistance to multiple antibiotics |
| Publications | Srikumar R, et al. 1998. Antimicrob Agents Chemother 42(1): 65-71. Expression of Pseudomonas aeruginosa multidrug efflux pumps MexA-MexB-OprM and MexC-MexD-OprJ in a multidrug-sensitive Escherichia coli strain. (PMID 9449262) Nehme D and Poole K. 2007. J Bacteriol 189(17): 6118-6127. Assembly of the MexAB-OprM multidrug pump of Pseudomonas aeruginosa: component interactions defined by the study of pump mutant suppressors. (PMID 17586626) Nehme D and Poole K. 2005. Antimicrob Agents Chemother 49(10): 4375-4378. Interaction of the MexA and MexB components of the MexAB-OprM multidrug efflux system of Pseudomonas aeruginosa: identification of MexA extragenic suppressors of a T578I mutation in MexB. (PMID 16189126) Sugimura M, et al. 2008. Antimicrob Agents Chemother 52(11): 4141-4144. Macrolide antibiotic-mediated downregulation of MexAB-OprM efflux pump expression in Pseudomonas aeruginosa. (PMID 18676884) Pamp SJ, et al. 2008. Mol Microbiol 68(1): 223-240. Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes. (PMID 18312276) |