carbapenem [Drug Class]

Accession ARO:0000020
DefinitionCarbapenems are a class of beta-lactam antibiotics with a broad spectrum of antibacterial activity, and have a structure which renders them highly resistant to beta-lactamases. Carbapenem antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
65 ontology terms | Show
+ ertapenem [Antibiotic]
+ meropenem [Antibiotic]
+ imipenem [Antibiotic]
+ doripenem [Antibiotic]
+ panipenem [Antibiotic]
+ EBR beta-lactamase [AMR Gene Family]
+ tebipenem [Antibiotic]
+ CAM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ PNGM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ NDM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ MUS beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ TMB beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ ADC beta-lactamase with carbapenemase activity [AMR Gene Family] confers_resistance_to_drug_class
+ VCC beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ subclass B3 PEDO beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ subclass B1 PEDO beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ CPS beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ ESP beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ MSI beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ SPG beta-lacatamase [AMR Gene Family] confers_resistance_to_drug_class
+ CarO porin [AMR Gene Family] confers_resistance_to_drug_class
+ subclass B1 Vibrio cholerae varG beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ NmcA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ CcrA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ BlaB beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ JOHN beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ CGB beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ TUS beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ SIM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ CAU beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ BJP beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ Rm3 family beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ subclass B1 Bacillus anthracis Bla beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ KHM beta-latamase [AMR Gene Family] confers_resistance_to_drug_class
+ DIM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ HMB beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ SFH beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ FEZ beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ GOB beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ THIN-B beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ SMB beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ MSI-OXA family beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ MdsABC confers_resistance_to_drug_class
+ General Bacterial Porin with reduced permeability to beta-lactams [AMR Gene Family] confers_resistance_to_drug_class
+ Outer Membrane Porin (Opr) [AMR Gene Family] confers_resistance_to_drug_class
+ IND beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ IMP beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ GIM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ CphA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ SPM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ SME beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ IMI beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ GES beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ KPC beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ PER beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ SHV beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ ACT beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ PDC beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ VIM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ RSA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] confers_resistance_to_drug_class
+ CIA beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ BIC Beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ BKC Beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
+ FIM beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
Publications

Jacoby GA and Munoz-Price LS. 2005. N Engl J Med 352(4): 380-391. The new beta-lactamases. (PMID 15673804)

Bradford PA. 2001. Clin Microbiol Rev 14(4): 933-951. Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. (PMID 11585791)