| Accession | ARO:3000170 |
| Definition | Imipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes. |
| Drug Class | carbapenem |
| Classification | 3 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + carbapenem [Drug Class] |
| Sub-Term(s) | 24 ontology terms | Show + beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic + CAM-1 confers_resistance_to_antibiotic + Pseudomonas aeruginosa oprD with mutation conferring resistance to imipenem confers_resistance_to_antibiotic + MexPQ-OpmE confers_resistance_to_antibiotic + NDM-1 confers_resistance_to_antibiotic + Acinetobacter baumannii OprD conferring resistance to imipenem confers_resistance_to_antibiotic + Klebsiella pneumoniae KpnGH-TolC confers_resistance_to_antibiotic + Burkholderia pseudomallei Omp38 confers_resistance_to_antibiotic + AdeIJK confers_resistance_to_antibiotic + crxA confers_resistance_to_antibiotic + Klebsiella aerogenes Omp36 confers_resistance_to_antibiotic + Klebsiella pneumoniae OmpK35 confers_resistance_to_antibiotic + carO confers_resistance_to_antibiotic + VIM-63 confers_resistance_to_antibiotic + YEM-1 confers_resistance_to_antibiotic + VMB-1 confers_resistance_to_antibiotic + VCC-1 confers_resistance_to_antibiotic + PJM-1 confers_resistance_to_antibiotic + KPC-87 confers_resistance_to_antibiotic + WUS-1 confers_resistance_to_antibiotic + LptD confers_resistance_to_antibiotic + FRI-11 confers_resistance_to_antibiotic + imipenem-cloxacillin [Antibiotic] has_part + imipenem-cilastatin-relebactam [Antibiotic+Adjuvant] has_part |
| Publications | Edwards JR and Betts MJ. 2000. J Antimicrob Chemother 45(1): 1-4. Carbapenems: the pinnacle of the beta-lactam antibiotics or room for improvement?. (PMID 10629005) Nordmann P and Poirel L. 2002. Clin Microbiol Infect 8(6): 321-331. Emerging carbapenemases in Gram-negative aerobes. (PMID 12084099) |
