imipenem [Antibiotic]

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Accession ARO:3000170
DefinitionImipenem is a broad-spectrum antibiotic and is usually taken with cilastatin, which prevents hydrolysis of imipenem by renal dehydropeptidase-I. It is resistant to hydrolysis by most other beta-lactamases. Notable exceptions are the KPC beta-lactamases and Ambler Class B enzymes.
Drug Classcarbapenem
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ carbapenem [Drug Class]
24 ontology terms | Show
+ beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic
+ CAM-1 confers_resistance_to_antibiotic
+ Pseudomonas aeruginosa oprD with mutation conferring resistance to imipenem confers_resistance_to_antibiotic
+ MexPQ-OpmE confers_resistance_to_antibiotic
+ NDM-1 confers_resistance_to_antibiotic
+ Acinetobacter baumannii OprD conferring resistance to imipenem confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnGH-TolC confers_resistance_to_antibiotic
+ Burkholderia pseudomallei Omp38 confers_resistance_to_antibiotic
+ AdeIJK confers_resistance_to_antibiotic
+ crxA confers_resistance_to_antibiotic
+ Klebsiella aerogenes Omp36 confers_resistance_to_antibiotic
+ Klebsiella pneumoniae OmpK35 confers_resistance_to_antibiotic
+ carO confers_resistance_to_antibiotic
+ VIM-63 confers_resistance_to_antibiotic
+ YEM-1 confers_resistance_to_antibiotic
+ VMB-1 confers_resistance_to_antibiotic
+ VCC-1 confers_resistance_to_antibiotic
+ PJM-1 confers_resistance_to_antibiotic
+ KPC-87 confers_resistance_to_antibiotic
+ WUS-1 confers_resistance_to_antibiotic
+ LptD confers_resistance_to_antibiotic
+ FRI-11 confers_resistance_to_antibiotic
+ imipenem-cloxacillin [Antibiotic] has_part
+ imipenem-cilastatin-relebactam [Antibiotic+Adjuvant] has_part

Edwards JR and Betts MJ. 2000. J Antimicrob Chemother 45(1): 1-4. Carbapenems: the pinnacle of the beta-lactam antibiotics or room for improvement?. (PMID 10629005)

Nordmann P and Poirel L. 2002. Clin Microbiol Infect 8(6): 321-331. Emerging carbapenemases in Gram-negative aerobes. (PMID 12084099)