AdeIJK

Accession ARO:3000772
DefinitionAdeIJK is a RND multidrug efflux pump expressed in Acinetobacter baumannii. It contributes to resistance for beta-lactams, chloramphenicol, tetracycline, erythromycin, lincosamides, fluoroquinolone, fusidic acid, novobiocin, rifampicin, trimethoprim, acridine, pyronine, and safranin.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, macrolide antibiotic, glycylcycline, triclosan, carbapenem, rifamycin antibiotic, aminoglycoside antibiotic, monobactam, penem, phenicol antibiotic, aminocoumarin antibiotic, antibacterial free fatty acids, penam, fluoroquinolone antibiotic, diaminopyrimidine antibiotic, acridine dye, lincosamide antibiotic, cephalosporin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification25 ontology terms | Show
Parent Term(s)11 ontology terms | Show
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ confers_resistance_to_antibiotic rifampin [Antibiotic]
+ confers_resistance_to_drug_class lincosamide antibiotic [Drug Class]
+ confers_resistance_to_drug_class macrolide antibiotic [Drug Class]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
+ confers_resistance_to_antibiotic ticarcillin [Antibiotic]
+ confers_resistance_to_antibiotic imipenem [Antibiotic]
+ confers_resistance_to_antibiotic trimethoprim [Antibiotic]
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
Sub-Term(s)
4 ontology terms | Show
+ adeI part_of
+ adeJ part_of
+ adeK part_of
+ adeN regulates
Publications

Damier-Piolle L, et al. 2008. Antimicrob Agents Chemother 52(2): 557-562. AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. (PMID 18086852)