adeJ

Accession ARO:3000781
CARD Short NameadeJ
DefinitionAdeJ is a RND efflux protein that acts as the inner membrane transporter of the AdeIJK efflux complex. It has 57% identity with E. coli AcrB.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classcarbapenem, diaminopyrimidine antibiotic, rifamycin antibiotic, phenicol antibiotic, penem, tetracycline antibiotic, fluoroquinolone antibiotic, macrolide antibiotic, lincosamide antibiotic, cephalosporin
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Sequence VariantsAcinetobacter baumanniig+p+wgs
Classification25 ontology terms | Show
Parent Term(s)2 ontology terms | Show
Publications

Damier-Piolle L, et al. 2008. Antimicrob Agents Chemother 52(2): 557-562. AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii. (PMID 18086852)

Resistomes

Prevalence of adeJ among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Acinetobacter baumannii96.99%0.1%62.95%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 2000


>gb|AAX14802.1|+|adeJ [Acinetobacter baumannii]
MAQFFIHRPIFAWVIALVIMLAGILTLTKMPIAQYPTIAPPTVTIAATYPGASAETVENTVTQIIEQQMNGLDGLRYISSNSAGNGQASI
QLNFEQGVDPDIAQVQVQNKLQSATALLPEDVQRQGVTVTKSGASFLQVIAFYSPDNNLSDSDIKDYVNSSIKEPLSRVAGVGEVQVFGG
SYAMRIWLDPAKLTSYQLTPSDIATALQAQNSQVAVGQLGGAPAVQGQVLNATVNAQSLLQTPEQFKNIFLKNTASGAEVRLKDVARVEL
GSDNYQFDSKFNGKPAAGLAIKIATGANALDTAEAVEQRLSELRKNYPTGLADKLAYDTTPFIRLSIESVVHTLIEAVILVFIVMFLFLQ
NWRATIIPTLAVPVVVLGTFAVINIFGFSINTLTMFAMVLAIGLLVDDAIVVVENVERVMSEDHTDPVTATSRSMQQISGALVGITSVLT
AVFVPMAFFGGTTGVIYRQFSITLVTAMVLSLIVALTFTPALCATILKQHDPNKEPSNNIFARFFRSFNNGFDRMSHSYQNGVSRMLKGK
IFSGVLYAVVVALLVFLFQKLPSSFLPEEDQGVVMTLVQLPPNATLDRTGKVIDTMTNFFMNEKDTVESIFTVSGFSFTGVGQNAGIGFV
KLKDWSKRTTPETQIGSLIQRGMALNMIIKDASYVMPLQLPAMPELGVTAGFNLQLKDSSGQGHEKLIAARNTILGLASQDKRLVGVRPN
GQEDTPQYQINVDQAQAGAMGVSIAEINNTMRIAWGGSYINDFVDRGRVKKVYVQGDAGSRMMPEDLNKWYVRNNKGEMVPFSAFATGEW
TYGSPRLERYNGVSSVNIQGTPAPGVSSGDAMKAMEEIIGKLPSMGLQGFDYEWTGLSLEERESGAQAPFLYALSLLIVFLCLAALYESW
SIPFSVLLVVPLGVIGAIVLTYLGMIIKGDPNLSNNIYFQVAIIAVIGLSAKNAILIVEFAKELQEKGEDLLDATLHAAKMRLRPIIMTT
LAFGFGVLPLALSTGAGAGSQHSVGFGVLGGVLSATFLGIFFIPVFYVWIRSMFKYKPKTINTQEHKS


>gb|AY769962.1|+|2435-5611|adeJ [Acinetobacter baumannii]
ATGGCACAATTTTTTATTCATCGCCCCATATTTGCGTGGGTGATTGCATTAGTCATTATGTTGGCGGGTATTCTTACGCTAACAAAAATG
CCTATTGCACAATATCCAACGATTGCACCACCAACCGTAACGATTGCTGCGACTTATCCTGGTGCATCGGCTGAAACAGTTGAAAATACT
GTAACCCAGATCATTGAACAACAAATGAATGGTCTTGATGGCTTACGTTATATTTCATCTAACAGTGCTGGTAATGGTCAGGCATCTATT
CAATTAAACTTTGAACAAGGTGTTGACCCTGATATTGCACAGGTTCAAGTTCAAAACAAATTGCAATCTGCAACTGCGCTTTTACCTGAA
GATGTACAACGTCAAGGTGTAACAGTTACTAAATCTGGTGCGAGCTTCTTGCAAGTTATTGCATTCTATTCACCAGATAACAACCTGTCA
GACTCTGACATTAAAGACTACGTAAACTCGTCAATTAAAGAACCGCTTAGCCGTGTTGCCGGTGTTGGTGAGGTACAGGTCTTCGGTGGC
TCATACGCAATGCGTATCTGGCTTGATCCAGCTAAATTAACAAGCTATCAACTTACTCCTAGTGATATTGCAACTGCCTTACAAGCGCAG
AACTCGCAAGTTGCCGTAGGTCAGTTAGGTGGTGCTCCGGCTGTACAAGGTCAAGTTCTTAACGCAACAGTAAATGCACAAAGCTTATTG
CAGACTCCTGAACAGTTTAAAAATATCTTCTTAAAGAACACAGCATCAGGTGCTGAGGTTCGATTAAAAGATGTTGCTCGCGTAGAATTA
GGTTCGGATAACTATCAATTCGACTCGAAGTTTAACGGTAAACCGGCAGCTGGTCTTGCAATTAAAATTGCAACAGGTGCTAACGCACTC
GACACAGCCGAAGCAGTTGAACAACGTTTATCTGAACTACGTAAGAACTATCCAACAGGTCTTGCAGATAAACTGGCTTATGACACGACT
CCATTTATCCGTCTTTCAATTGAAAGTGTAGTACACACATTAATTGAAGCCGTGATTTTGGTATTCATTGTCATGTTCCTATTCTTACAA
AACTGGCGTGCAACGATTATTCCAACGCTTGCAGTTCCAGTAGTTGTATTAGGTACATTTGCGGTCATTAATATCTTTGGCTTCTCAATT
AACACCTTAACCATGTTCGCTATGGTATTGGCAATCGGTCTTCTGGTCGACGACGCCATTGTTGTAGTCGAAAACGTTGAACGTGTGATG
AGTGAAGACCATACCGATCCGGTTACGGCCACTTCTCGCTCAATGCAGCAGATTTCTGGTGCGTTAGTAGGTATTACCAGCGTATTGACA
GCGGTATTCGTACCAATGGCTTTCTTTGGTGGTACAACAGGTGTAATTTACCGCCAGTTCTCGATTACCCTTGTAACTGCAATGGTTCTG
TCGTTAATTGTAGCGTTGACGTTCACACCGGCACTTTGTGCAACTATCTTGAAACAGCATGATCCTAATAAAGAACCAAGCAATAATATC
TTTGCGCGTTTCTTTAGAAGCTTTAACAATGGTTTTGACCGCATGTCGCATAGCTACCAAAATGGTGTTAGCCGCATGCTTAAAGGCAAA
ATCTTCTCTGGCGTGCTCTATGCTGTTGTAGTTGCCCTTTTAGTCTTCTTGTTCCAAAAACTCCCGTCTTCATTCTTACCAGAAGAAGAT
CAGGGTGTGGTCATGACACTTGTACAATTACCACCAAATGCAACGCTTGACCGTACCGGTAAAGTGATTGATACCATGACTAACTTCTTT
ATGAATGAAAAAGATACCGTGGAATCTATTTTCACTGTTTCTGGTTTCTCATTCACAGGTGTTGGTCAAAACGCGGGTATTGGCTTCGTT
AAGTTGAAAGACTGGAGCAAACGTACGACACCAGAAACTCAAATTGGTTCATTGATTCAGCGTGGTATGGCATTAAATATGATCATTAAA
GATGCATCATACGTTATGCCGTTACAGCTTCCAGCAATGCCTGAACTTGGTGTAACTGCCGGATTTAACTTGCAGCTTAAAGATTCAAGT
GGTCAAGGCCATGAGAAACTGATTGCAGCTCGTAACACGATTTTAGGTTTGGCATCACAAGATAAACGTCTTGTAGGTGTGCGTCCAAAT
GGTCAGGAAGATACTCCTCAGTATCAAATTAATGTAGATCAGGCTCAAGCTGGTGCTATGGGCGTTAGTATTGCCGAAATCAACAATACA
ATGCGTATTGCATGGGGTGGCTCATACATTAACGATTTCGTTGACCGTGGTCGTGTGAAAAAAGTTTATGTTCAAGGTGATGCGGGCAGC
CGTATGATGCCTGAAGACTTAAACAAATGGTATGTACGTAATAACAAAGGTGAGATGGTTCCATTCTCGGCATTTGCTACAGGCGAATGG
ACGTATGGTTCTCCACGTCTCGAACGTTATAACGGCGTGTCATCGGTTAACATTCAAGGTACACCTGCACCTGGCGTGAGCTCTGGTGAT
GCCATGAAAGCAATGGAAGAAATTATTGGTAAGTTACCATCTATGGGCTTACAAGGTTTCGACTATGAGTGGACAGGCTTATCACTTGAA
GAACGTGAGTCTGGTGCTCAAGCGCCGTTCTTATACGCACTTTCATTGTTAATCGTATTCCTTTGCTTGGCTGCACTATATGAAAGCTGG
TCAATTCCGTTCTCGGTTTTACTTGTGGTACCACTTGGTGTCATTGGTGCAATCGTATTGACCTACTTGGGCATGATTATTAAAGGAGAT
CCAAATCTCTCAAATAACATTTACTTCCAGGTAGCGATTATTGCGGTTATCGGTCTTTCTGCAAAAAATGCGATCTTGATTGTTGAATTC
GCAAAAGAATTGCAGGAAAAAGGTGAAGATCTACTTGATGCAACCTTACATGCTGCAAAAATGCGTTTACGTCCAATTATCATGACCACC
CTTGCCTTCGGTTTCGGTGTACTTCCACTTGCACTTTCAACAGGTGCCGGTGCAGGAAGTCAGCACTCTGTAGGCTTTGGTGTACTTGGT
GGCGTACTCAGCGCGACGTTCTTAGGAATCTTCTTTATCCCTGTATTCTATGTGTGGATTCGTAGTATGTTTAAGTACAAACCAAAAACC
ATAAACACTCAGGAGCATAAATCGTGA