rifamycin antibiotic [Drug Class]

Accession ARO:3000157
DefinitionRifamycin antibiotics are a group of broad-spectrum ansamycin antibiotics that inhibit bacterial RNA polymerase by binding to a highly conserved region, blocking the oligonucleotide exit tunnel, and preventing the extension of nascent mRNAs.
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
21 ontology terms | Show
+ rifampin [Antibiotic]
+ rifaximin [Antibiotic]
+ rifabutin [Antibiotic]
+ rifapentine [Antibiotic]
+ Rifalazil [Antibiotic]
+ lassomycin [Antibiotic]
+ rifamycin sensitive beta-subunit of RNA polymerase (rpoB) targeted_by
+ antibiotic sensitive beta-subunit of RNA polymerase (rpoB) targeted_by
+ rifamycin-resistant arabinosyltransferase [AMR Gene Family] confers_resistance_to_drug_class
+ rifamycin-resistant beta-subunit of RNA polymerase (rpoB) [AMR Gene Family] confers_resistance_to_drug_class
+ determinant of rifamycin resistance confers_resistance_to_drug_class
+ daptomycin resistant beta-subunit of RNA polymerase (rpoB) [AMR Gene Family] confers_resistance_to_drug_class
+ rifampin ADP-ribosyltransferase (Arr) [AMR Gene Family] confers_resistance_to_drug_class
+ rifampin glycosyltransferase [AMR Gene Family] confers_resistance_to_drug_class
+ rifampin phosphotransferase [AMR Gene Family] confers_resistance_to_drug_class
+ rifampin monooxygenase [AMR Gene Family] confers_resistance_to_drug_class
+ RbpA bacterial RNA polymerase-binding protein [AMR Gene Family] confers_resistance_to_drug_class
+ DnaA chromosomal replication initiation protein [AMR Gene Family] confers_resistance_to_drug_class
+ ATP-binding cassette (ABC) antibiotic efflux pump [AMR Gene Family] confers_resistance_to_drug_class
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] confers_resistance_to_drug_class
+ LAP beta-lactamase [AMR Gene Family] confers_resistance_to_drug_class
Publications

Floss HG and Yu TW. 2005. Chem Rev 105(2): 621-632. Rifamycin-mode of action, resistance, and biosynthesis. (PMID 15700959)