| Accession | ARO:3000210 |
| Definition | Rifampin resistant RNA polymerases include amino acids substitutions which disrupt the affinity of rifampin for its binding site. These mutations are frequently concentrated in the rif I region of the beta-subunit and most often involve amino acids which make direct interactions with rifampin. However, mutations which also confer resistance can occur outside this region and may involve amino acids which do not directly make contact with rifampin. |
| Drug Class | rifamycin antibiotic |
| Resistance Mechanism | antibiotic target alteration, antibiotic target replacement |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic target replacement [Resistance Mechanism] + antibiotic molecule + antibiotic resistant gene variant or mutant |
| Parent Term(s) | 4 ontology terms | Show + derives_from rifamycin sensitive beta-subunit of RNA polymerase (rpoB) + antibiotic resistant rpoB + confers_resistance_to_drug_class rifamycin antibiotic [Drug Class] + antibiotic target replacement protein |
| Sub-Term(s) | 9 ontology terms | Show + Bifidobacterium adolescentis rpoB mutants conferring resistance to rifampicin + rpoB2 + Clostridioides difficile rpoB with mutation conferring resistance to rifampicin + Mycobacterium leprae rpoB mutations conferring resistance to rifampicin + Escherichia coli rpoB mutants conferring resistance to rifampicin + Mycobacterium tuberculosis rpoB mutants conferring resistance to rifampicin + Staphylococcus aureus rpoB mutants conferring resistance to rifampicin + Helicobacter pylori rpoB mutation conferring resistance to rifampicin + Bacillus subtilis rpoB mutants conferring resistance to rifampin |
| Publications | Jin DJ and Gross CA. 1988. J Mol Biol 202(1): 45-58. Mapping and sequencing of mutations in the Escherichia coli rpoB gene that lead to rifampicin resistance. (PMID 3050121) Mariam DH, et al. 2004. Antimicrob Agents Chemother 48(4): 1289-1294. Effect of rpoB mutations conferring rifampin resistance on fitness of Mycobacterium tuberculosis. (PMID 15047531) Heep M, et al. 2001. J Clin Microbiol 39(1): 107-110. Frequency of rpoB mutations inside and outside the cluster I region in rifampin-resistant clinical Mycobacterium tuberculosis isolates. (PMID 11136757) Pecavar V, et al. 2012. J Med Microbiol 61(PT 6): 780-785. High-resolution melting analysis of the single nucleotide polymorphism hot-spot region in the rpoB gene as an indicator of reduced susceptibility to rifaximin in Clostridium difficile. (PMID 22361457) Wichelhaus TA, et al. 1999. Antimicrob Agents Chemother 43(11): 2813-2816. Molecular characterization of rpoB mutations conferring cross-resistance to rifamycins on methicillin-resistant Staphylococcus aureus. (PMID 10543773) Mokrousov I, et al. 2003. Antimicrob Agents Chemother 47(7): 2231-2235. Allele-specific rpoB PCR assays for detection of rifampin-resistant Mycobacterium tuberculosis in sputum smears. (PMID 12821473) Campbell PJ, et al. 2011. Antimicrob Agents Chemother 55(5): 2032-2041. Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis. (PMID 21300839) |