Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin

Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3003283
Synonym(s)Rv0667
CARD Short NameMtub_rpoB_RIF
DefinitionPoint mutations that occurs in Mycobacterium tuberculosis rpoB resulting in resistance to rifampicin.
AMR Gene Familyrifamycin-resistant beta-subunit of RNA polymerase (rpoB)
Drug Classrifamycin antibiotic
Resistance Mechanismantibiotic target alteration, antibiotic target replacement
Resistomes with Sequence VariantsMycobacterium tuberculosisg+wgs
Classification11 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ confers_resistance_to_antibiotic rifampin [Antibiotic]
+ rifamycin-resistant beta-subunit of RNA polymerase (rpoB) [AMR Gene Family]
+ confers_resistance_to_antibiotic rifaximin [Antibiotic]
+ confers_resistance_to_antibiotic rifabutin [Antibiotic]
+ confers_resistance_to_antibiotic rifapentine [Antibiotic]
Publications

Htike Min PK, et al. 2014. Southeast Asian J Trop Med Public Health 45(4): 843-852. Novel mutation detection IN rpoB OF rifampicin-resistant Mycobacterium tuberculosis using pyrosequencing. (PMID 25427352)

Campbell PJ, et al. 2011. Antimicrob Agents Chemother 55(5): 2032-2041. Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis. (PMID 21300839)

Madania A, et al. 2012. Pol J Microbiol 61(1): 23-32. Characterization of mutations causing rifampicin and isoniazid resistance of Mycobacterium tuberculosis in Syria. (PMID 22708343)

Mariam DH, et al. 2004. Antimicrob Agents Chemother 48(4): 1289-1294. Effect of rpoB mutations conferring rifampin resistance on fitness of Mycobacterium tuberculosis. (PMID 15047531)

Heep M, et al. 2001. J Clin Microbiol 39(1): 107-110. Frequency of rpoB mutations inside and outside the cluster I region in rifampin-resistant clinical Mycobacterium tuberculosis isolates. (PMID 11136757)

Heep M, et al. 2000. Antimicrob. Agents Chemother. 44(4):1075-7 Mutations in the beginning of the rpoB gene can induce resistance to rifamycins in both Helicobacter pylori and Mycobacterium tuberculosis. (PMID 10722516)

Taniguchi H, et al. 1996. FEMS Microbiol. Lett. 144(1):103-8 Rifampicin resistance and mutation of the rpoB gene in Mycobacterium tuberculosis. (PMID 8870258)

Cavusoglu C, et al. 2002. J. Clin. Microbiol. 40(12):4435-8 Characterization of rpoB mutations in rifampin-resistant clinical isolates of Mycobacterium tuberculosis from Turkey by DNA sequencing and line probe assay. (PMID 12454132)

Schilke K, et al. 1999. Int. J. Tuberc. Lung Dis. 3(7):620-6 Universal pattern of RpoB gene mutations among multidrug-resistant isolates of Mycobacterium tuberculosis complex from Africa. (PMID 10423225)

Sekiguchi J, et al. 2007. J Clin Microbiol 45(1): 179-192. Detection of multidrug resistance in Mycobacterium tuberculosis. (PMID 17108078)

Zenteno-Cuevas R, et al. 2009. Mem. Inst. Oswaldo Cruz 104(3):468-72 Mutations in rpoB and katG genes in Mycobacterium isolates from the Southeast of Mexico. (PMID 19547874)

Sajduda A, et al. 2004. J. Clin. Microbiol. 42(6):2425-31 Molecular characterization of rifampin- and isoniazid-resistant Mycobacterium tuberculosis strains isolated in Poland. (PMID 15184414)

Kapur V, et al. 1994. J. Clin. Microbiol. 32(4):1095-8 Characterization by automated DNA sequencing of mutations in the gene (rpoB) encoding the RNA polymerase beta subunit in rifampin-resistant Mycobacterium tuberculosis strains from New York City and Texas. (PMID 8027320)

Siddiqi N, et al. 2002. Antimicrob. Agents Chemother. 46(2):443-50 Molecular characterization of multidrug-resistant isolates of Mycobacterium tuberculosis from patients in North India. (PMID 11796356)

Ramaswamy S, et al. 1998. Tuber. Lung Dis. 79(1):3-29 Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update. (PMID 10645439)

Chan RC, et al. 2007. J Antimicrob Chemother 59(5): 866-873. Genetic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates in Hong Kong. (PMID 17360809)

Bahrmand AR, et al. 2009. J. Clin. Microbiol. 47(9):2744-50 High-level rifampin resistance correlates with multiple mutations in the rpoB gene of pulmonary tuberculosis isolates from the Afghanistan border of Iran. (PMID 19721079)

Prammananan T, et al. 2008. Clin. Microbiol. Infect. 14(5):446-53 Distribution of rpoB mutations among multidrug-resistant Mycobacterium tuberculosis (MDRTB) strains from Thailand and development of a rapid method for mutation detection. (PMID 18294243)

Kim BJ, et al. 1997. J. Clin. Microbiol. 35(2):492-4 Mutations in the rpoB gene of Mycobacterium tuberculosis that interfere with PCR-single-strand conformation polymorphism analysis for rifampin susceptibility testing. (PMID 9003625)

Valim AR, et al. 2000. J. Clin. Microbiol. 38(8):3119-22 Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis isolates from Brazil. (PMID 10921994)

O'Sullivan DM, et al. 2005. J. Antimicrob. Chemother. 55(5):674-9 Analysis of rpoB and pncA mutations in the published literature: an insight into the role of oxidative stress in Mycobacterium tuberculosis evolution?. (PMID 15814606)

Wu X, et al. 2009. Mol. Biotechnol. 41(1):1-7 Identification of rifampin-resistant genotypes in Mycobacterium tuberculosis by PCR-reverse dot blot hybridization. (PMID 18600483)

Mani C, et al. 2001. J. Clin. Microbiol. 39(8):2987-90 Mutations in the rpoB gene of multidrug-resistant Mycobacterium tuberculosis clinical isolates from India. (PMID 11474030)

Hillemann D, et al. 2005. Antimicrob. Agents Chemother. 49(3):1229-31 Disequilibrium in distribution of resistance mutations among Mycobacterium tuberculosis Beijing and non-Beijing strains isolated from patients in Germany. (PMID 15728936)

Heym B, et al. 1994. Lancet 344(8918):293-8 Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: a molecular study. (PMID 7914261)

Pozzi G, et al. 1999. J. Clin. Microbiol. 37(4):1197-9 rpoB mutations in multidrug-resistant strains of Mycobacterium tuberculosis isolated in Italy. (PMID 10074552)

Williams DL, et al. 1994. Antimicrob. Agents Chemother. 38(10):2380-6 Characterization of rifampin-resistance in pathogenic mycobacteria. (PMID 7840574)

Wang Q, et al. 2007. J. Proteome Res. 6(12):4564-71 A newly identified 191A/C mutation in the Rv2629 gene that was significantly associated with rifampin resistance in Mycobacterium tuberculosis. (PMID 17970586)

Aslan G, et al. 2008. Jpn. J. Infect. Dis. 61(4):255-60 Genotypic analysis of isoniazid and rifampin resistance in drug-resistant clinical Mycobacterium tuberculosis complex isolates in southern Turkey. (PMID 18653964)

Hauck Y, et al. 2009. J. Antimicrob. Chemother. 64(2):259-62 Comparison of two commercial assays for the characterization of rpoB mutations in Mycobacterium tuberculosis and description of new mutations conferring weak resistance to rifampicin. (PMID 19520715)

Takawira FT, et al. 2017. Pan Afr Med J 27:145 Mutations in rpoB and katG genes of multidrug resistant mycobacterium tuberculosis undetectable using genotyping diagnostic methods. (PMID 28904673)

Telenti A, et al. 1993. Lancet 341(8846):647-50 Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis. (PMID 8095569)

Bouziane F, et al. 2019. J Glob Antimicrob Resist : First genetic characterization of multi-drug resistant Mycobacterium tuberculosis isolates from Algeria. (PMID 31100498)

Ezewudo M, et al. 2018. Sci Rep 8(1):15382 Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase. (PMID 30337678)

The CRyPTIC Consortium 2022. PLoS Biol 20(8):e3001721 A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics. (PMID 35944069)

World Health Organization. 2023. ISBN 978-92-4-008241-0. Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance. Second Edition. (ISBN 978-92-4-008241-0)

Resistomes

Prevalence of Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein variant model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Mycobacterium tuberculosis98.77%0%98.36%0%0%
Show Perfect Only


Detection Models

Model Type: protein variant model

Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.

Bit-score Cut-off (blastP): 2300

PubMed: mutation data hand curated from the scientific literature, evaluated as conferring resistance (R). CRyPTIC: mutation data acquired from the CRyPTIC catalog, evaluated as resistant (R), susceptible (S), or undetermined (U). ReSeqTB: mutation data acquired from the ReSeqTB catalog, evaluated as conferring resistance (Minimal, Moderate, High), not conferring resistance (None), or Indeterminate. WHO: mutation data acquired from the WHO 2023 catalog, evaluated as resistant (R), susceptible (S), or undetermined (U).

MutationMutation typePubMedReSeqTBCRyPTICWHO
P45Lsingle resistance variantno dataReSeqTB-Highno datano data
P45Ssingle resistance variantno dataReSeqTB-Moderateno dataWHO-U
V170Fsingle resistance variantPMID:10722516no dataCRyPTIC-RWHO-R
A286Vsingle resistance variantPMID:8870258no datano datano data
V359Asingle resistance variantno datano dataCRyPTIC-Rno data
Q409Hsingle resistance variantPMID:12454132no datano datano data
E423Asingle resistance variantPMID:10423225no datano datano data
F425Varsingle resistance variantno datano dataCRyPTIC-Rno data
G426Dsingle resistance variantPMID:19721079no datano datano data
G426Varsingle resistance variantno datano dataCRyPTIC-Rno data
G426Ssingle resistance variantPMID:19721079no datano dataWHO-R
T427Ssingle resistance variantPMID:11474030no datano dataWHO-R
T427Psingle resistance variantPMID:19721079no datano dataWHO-R
T427Nsingle resistance variantPMID:28904673no datano dataWHO-R
T427Varsingle resistance variantno datano dataCRyPTIC-Rno data
T427Hsingle resistance variantPMID:19721079no datano datano data
T427Isingle resistance variantno datano datano dataWHO-R
T427Gsingle resistance variantno datano datano dataWHO-R
T427Asingle resistance variantPMID:19721079no datano dataWHO-R
S428Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
S428Gsingle resistance variantno datano datano dataWHO-R
S428Tsingle resistance variantno datano datano dataWHO-R
S428Isingle resistance variantno datano datano dataWHO-R
S428Rsingle resistance variantPMID:17108078no datano dataWHO-R
S428Qsingle resistance variantPMID:19547874no datano datano data
Q429Lsingle resistance variantno datano datano dataWHO-R
Q429Hsingle resistance variantno datano datano dataWHO-R
Q429Psingle resistance variantno datano datano dataWHO-R
Q429Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
L430Rsingle resistance variantPMID:8027320no datano dataWHO-R
L430Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
L430R,D435Vmultiple resistance variantsPMID:10921994no datano datano data
L430Msingle resistance variantPMID:11474030no datano datano data
L430Vsingle resistance variantPMID:11796356no datano datano data
L430P,M434Imultiple resistance variantsPMID:10921994no datano datano data
L430Psingle resistance variantPMID:10423225ReSeqTB-MinimalCRyPTIC-RWHO-R
S431Tsingle resistance variantPMID:8027320no dataCRyPTIC-RWHO-R
S431Gsingle resistance variantno datano datano dataWHO-R
S431Nsingle resistance variantPMID:28904673no datano dataWHO-R
S431Isingle resistance variantPMID:15184414no datano datano data
S431Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
S431Rsingle resistance variantPMID:10645439no datano dataWHO-R
Q432Esingle resistance variantPMID:19721079no datano dataWHO-R
Q432Nsingle resistance variantno datano datano dataWHO-R
Q432Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
Q432Rsingle resistance variantPMID:15814606no datano datano data
Q432Psingle resistance variantPMID:12454132ReSeqTB-HighCRyPTIC-RWHO-R
Q432Hsingle resistance variantno datano datano dataWHO-R
Q432deldeletion mutation from peptide sequencePMID:28904673no datano datano data
Q432Lsingle resistance variantPMID:10423225no dataCRyPTIC-RWHO-R
Q432Ternonsense mutationPMID:19721079no datano datano data
Q432Ksingle resistance variantPMID:10423225no dataCRyPTIC-RWHO-R
Q432Dsingle resistance variantPMID:19721079no datano datano data
F433deldeletion mutation from peptide sequencePMID:28904673no datano datano data
F433Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
M434Lsingle resistance variantno datano datano dataWHO-R
M434deldeletion mutation from peptide sequencePMID:28904673no datano datano data
M434Vsingle resistance variantPMID:22708343no datano dataWHO-R
M434Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
M434Tsingle resistance variantno datano datano dataWHO-R
M434Isingle resistance variantPMID:22708343ReSeqTB-HighCRyPTIC-RWHO-R
M434Rsingle resistance variantno datano datano dataWHO-R
D435Ksingle resistance variantPMID:11474030no datano datano data
D435Ysingle resistance variantPMID:22708343ReSeqTB-MinimalCRyPTIC-RWHO-R
D435Fsingle resistance variantno datano dataCRyPTIC-RWHO-R
D435Esingle resistance variantno datano datano dataWHO-R
D435Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
D435Nsingle resistance variantPMID:10423225no dataCRyPTIC-RWHO-R
D435Y,L430Rmultiple resistance variantsPMID:18294243no datano datano data
D435Asingle resistance variantno datano dataCRyPTIC-RWHO-R
D435Vsingle resistance variantPMID:22708343ReSeqTB-HighCRyPTIC-RWHO-R
D435Gsingle resistance variantPMID:10423225ReSeqTB-HighCRyPTIC-RWHO-R
D435E,S441Lmultiple resistance variantsPMID:18294243no datano datano data
D435Lsingle resistance variantno datano datano dataWHO-R
D435Tsingle resistance variantPMID:22708343no datano datano data
D435deldeletion mutation from peptide sequencePMID:28904673no datano datano data
D435Hsingle resistance variantPMID:19721079no datano dataWHO-R
Q436Nsingle resistance variantno datano datano dataWHO-R
Q436Hsingle resistance variantPMID:18600483no datano datano data
Q436Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
Q436deldeletion mutation from peptide sequencePMID:11474030no datano datano data
Q436Lsingle resistance variantPMID:19547874no datano datano data
Q436Psingle resistance variantno datano datano dataWHO-R
Q436Rsingle resistance variantno datano datano dataWHO-R
N437Dsingle resistance variantno datano datano dataWHO-R
N437deldeletion mutation from peptide sequencePMID:28904673no datano datano data
N437Ssingle resistance variantno datano datano dataWHO-R
N437Ysingle resistance variantno datano datano dataWHO-R
N437Tsingle resistance variantPMID:11796356no datano datano data
N437Isingle resistance variantPMID:15728936no datano dataWHO-R
N437Hsingle resistance variantPMID:11474030no datano dataWHO-R
N437Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
N438Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
N438Ksingle resistance variantPMID:19721079no datano datano data
N438Hsingle resistance variantno datano datano dataWHO-R
P439Asingle resistance variantno datano datano dataWHO-R
P439Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
P439Ssingle resistance variantno datano datano dataWHO-R
P439deldeletion mutation from peptide sequencePMID:19721079no datano datano data
P439Lsingle resistance variantno datano datano dataWHO-R
P439Tsingle resistance variantPMID:28904673no datano datano data
L440Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
L440Msingle resistance variantPMID:10645439no datano datano data
L440Psingle resistance variantPMID:8870258no datano datano data
S441Wsingle resistance variantPMID:12454132no datano dataWHO-R
S441Qsingle resistance variantPMID:11136757 PMID:11796356no dataCRyPTIC-RWHO-R
S441Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
S441Vsingle resistance variantno datano datano dataWHO-R
S441Msingle resistance variantno datano datano dataWHO-R
S441Ternonsense mutationPMID:15814606no datano datano data
S441Asingle resistance variantno datano datano dataWHO-R
S441Ksingle resistance variantno datano datano dataWHO-R
S441Lsingle resistance variantPMID:18294243no dataCRyPTIC-RWHO-R
G442Esingle resistance variantno datano datano dataWHO-R
G442Asingle resistance variantPMID:19721079no datano datano data
G442Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
L443Wsingle resistance variantno datano datano dataWHO-R
L443Ssingle resistance variantPMID:19547874no datano dataWHO-R
L443Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
L443Fsingle resistance variantno datano dataCRyPTIC-SWHO-R
T444Ssingle resistance variantno datano datano dataWHO-R
T444Isingle resistance variantno datano datano dataWHO-R
T444Psingle resistance variantno datano datano dataWHO-R
T444Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
H445Csingle resistance variantPMID:11136757no dataCRyPTIC-RWHO-R
H445D,S450Lmultiple resistance variantsPMID:10074552no datano datano data
H445S,P454Hmultiple resistance variantsPMID:18294243no datano datano data
H445Lsingle resistance variantPMID:10423225ReSeqTB-ModerateCRyPTIC-RWHO-R
H445S,M434Vmultiple resistance variantsPMID:18294243no datano datano data
H445Ssingle resistance variantPMID:22708343no datano dataWHO-R
H445Nsingle resistance variantPMID:15184414no dataCRyPTIC-RWHO-R
H445Tsingle resistance variantPMID:15184414no datano dataWHO-R
H445Rsingle resistance variantPMID:11136757ReSeqTB-HighCRyPTIC-RWHO-R
H445Gsingle resistance variantPMID:10645439no dataCRyPTIC-RWHO-R
H445Dsingle resistance variantPMID:11136757ReSeqTB-HighCRyPTIC-RWHO-R
H445Ysingle resistance variantPMID:11136757ReSeqTB-HighCRyPTIC-RWHO-R
H445Psingle resistance variantPMID:15814606no dataCRyPTIC-RWHO-R
H445Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
H445Esingle resistance variantPMID:8027320no datano datano data
H445deldeletion mutation from peptide sequencePMID:28904673no datano datano data
H445Fsingle resistance variantPMID:19721079no dataCRyPTIC-RWHO-R
H445P,K446Qmultiple resistance variantsPMID:7840574no datano datano data
H445Qsingle resistance variantPMID:19721079no datano dataWHO-R
H445Y,E460Gmultiple resistance variantsPMID:18294243no datano datano data
K446Esingle resistance variantno datano datano dataWHO-R
K446Tsingle resistance variantno datano datano dataWHO-R
K446Nsingle resistance variantPMID:11796356no datano datano data
K446Qsingle resistance variantPMID:22708343no datano dataWHO-R
K446Rsingle resistance variantno datano datano dataWHO-R
K446Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
R447Hsingle resistance variantPMID:11796356no datano datano data
R447Psingle resistance variantPMID:19547874no datano datano data
R447Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
R448Ksingle resistance variantno datano datano dataWHO-R
R448Lsingle resistance variantno datano datano dataWHO-R
R448Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
R448Qsingle resistance variantPMID:15184414no datano dataWHO-R
L449Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
L449Msingle resistance variantno datano datano dataWHO-R
S450L,F433Vmultiple resistance variantsPMID:10921994no datano datano data
S450Wsingle resistance variantPMID:11136757ReSeqTB-HighCRyPTIC-RWHO-R
S450L,H445Cmultiple resistance variantsPMID:10921994no datano datano data
S450Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
S450Vsingle resistance variantno datano datano dataWHO-R
S450Qsingle resistance variantno datano dataCRyPTIC-RWHO-R
S450Msingle resistance variantno datano datano dataWHO-R
S450Gsingle resistance variantPMID:22708343no datano dataWHO-R
S450L,S540Amultiple resistance variantsPMID:18294243no datano datano data
S450Lsingle resistance variantPMID:17108078ReSeqTB-HighCRyPTIC-RWHO-R
S450Csingle resistance variantPMID:8027320no datano dataWHO-R
S450Ysingle resistance variantno datano dataCRyPTIC-RWHO-R
S450Asingle resistance variantno datano datano dataWHO-R
S450Fsingle resistance variantPMID:19721079no dataCRyPTIC-RWHO-R
A451Gsingle resistance variantno datano datano dataWHO-R
A451Vsingle resistance variantno datano datano dataWHO-R
A451Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
L452Rsingle resistance variantPMID:25427352no datano datano data
L452Varsingle resistance variantno datano dataCRyPTIC-RWHO-R
L452Vsingle resistance variantno datano datano dataWHO-R
L452Msingle resistance variantno datano datano dataWHO-R
L452Psingle resistance variantPMID:22708343ReSeqTB-MinimalCRyPTIC-RWHO-R
L457Psingle resistance variantPMID:17970586no datano datano data
L457Rsingle resistance variantPMID:25427352no datano datano data
L464Msingle resistance variantPMID:18653964no datano datano data
I480Vsingle resistance variantno dataReSeqTB-Highno datano data
E481G,P483Lmultiple resistance variantsPMID:19520715no datano datano data
L490Vsingle resistance variantPMID:11136757no datano datano data
I491Fsingle resistance variantPMID:15814606no dataCRyPTIC-RWHO-R
S493Lsingle resistance variantPMID:17360809no datano datano data
F503Ssingle resistance variantno dataReSeqTB-Highno dataWHO-U
F505Lsingle resistance variantPMID:17360809no datano datano data
D545Esingle resistance variantno datano dataCRyPTIC-Rno data
R552Csingle resistance variantPMID:11136757no datano datano data
E592Dsingle resistance variantPMID:11136757no datano datano data
T676Psingle resistance variantno datano dataCRyPTIC-Rno data
L731Psingle resistance variantno dataReSeqTB-Highno dataWHO-U
R827Hsingle resistance variantno dataReSeqTB-Highno datano data
H835Rsingle resistance variantno dataReSeqTB-Highno dataWHO-U
G836Ssingle resistance variantno dataReSeqTB-Highno datano data
Q975Hsingle resistance variantno dataReSeqTB-Highno datano data
G981Dsingle resistance variantno datano dataCRyPTIC-RWHO-U
I1106Tsingle resistance variantno dataReSeqTB-Highno dataWHO-U

>gb|NP_215181.1|+|Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin [Mycobacterium tuberculosis H37Rv]
MADSRQSKTAASPSPSRPQSSSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIG
SPRWRESAAERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVDECKDKD
MTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVVSQLVRSPGVY
FDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGVRIDRKRRQPVTVLLKALGWTSE
QIVERFGFSEIMRSTLEKDNTVGTDEALLDIYRKLRPGEPPTKESAQTLLENLFFKEKRY
DLARVGRYKVNKKLGLHVGEPITSSTLTEEDVVATIEYLVRLHEGQTTMTVPGGVEVPVE
TDDIDHFGNRRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLINIRPVVAA
IKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVHPSHYGRMCPI
ETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDGVVSDEIVYLTADEEDRHVVAQANS
PIDADGRFVEPRVLVRRKAGEVEYVPSSEVDYMDVSPRQMVSVATAMIPFLEHDDANRAL
MGANMQRQAVPLVRSEAPLVGTGMELRAAIDAGDVVVAEESGVIEEVSADYITVMHDNGT
RRTYRMRKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGEMALGKNLLVAIMPW
EGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNISDEVLADLDE
RGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGK
VIGIRVFSREDEDELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKILPVEDMPF
LADGTPVDIILNTHGVPRRMNIGQILETHLGWCAHSGWKVDAAKGVPDWAARLPDELLEA
QPNAIVSTPVFDGAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFDGRSGEPFPYPVTVG
YMYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQ
ELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIE
LREGEDEDLERAAANLGINLSRNESASVEDLA



>gb|NC_000962.3|+|759807-763325|Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin [Mycobacterium tuberculosis H37Rv]
TTGGCAGATTCCCGCCAGAGCAAAACAGCCGCTAGTCCTAGTCCGAGTCGCCCGCAAAGTTCCTCGAATAACTCCGTACCCGGAGCGCCA
AACCGGGTCTCCTTCGCTAAGCTGCGCGAACCACTTGAGGTTCCGGGACTCCTTGACGTCCAGACCGATTCGTTCGAGTGGCTGATCGGT
TCGCCGCGCTGGCGCGAATCCGCCGCCGAGCGGGGTGATGTCAACCCAGTGGGTGGCCTGGAAGAGGTGCTCTACGAGCTGTCTCCGATC
GAGGACTTCTCCGGGTCGATGTCGTTGTCGTTCTCTGACCCTCGTTTCGACGATGTCAAGGCACCCGTCGACGAGTGCAAAGACAAGGAC
ATGACGTACGCGGCTCCACTGTTCGTCACCGCCGAGTTCATCAACAACAACACCGGTGAGATCAAGAGTCAGACGGTGTTCATGGGTGAC
TTCCCGATGATGACCGAGAAGGGCACGTTCATCATCAACGGGACCGAGCGTGTGGTGGTCAGCCAGCTGGTGCGGTCGCCCGGGGTGTAC
TTCGACGAGACCATTGACAAGTCCACCGACAAGACGCTGCACAGCGTCAAGGTGATCCCGAGCCGCGGCGCGTGGCTCGAGTTTGACGTC
GACAAGCGCGACACCGTCGGCGTGCGCATCGACCGCAAACGCCGGCAACCGGTCACCGTGCTGCTCAAGGCGCTGGGCTGGACCAGCGAG
CAGATTGTCGAGCGGTTCGGGTTCTCCGAGATCATGCGATCGACGCTGGAGAAGGACAACACCGTCGGCACCGACGAGGCGCTGTTGGAC
ATCTACCGCAAGCTGCGTCCGGGCGAGCCCCCGACCAAAGAGTCAGCGCAGACGCTGTTGGAAAACTTGTTCTTCAAGGAGAAGCGCTAC
GACCTGGCCCGCGTCGGTCGCTATAAGGTCAACAAGAAGCTCGGGCTGCATGTCGGCGAGCCCATCACGTCGTCGACGCTGACCGAAGAA
GACGTCGTGGCCACCATCGAATATCTGGTCCGCTTGCACGAGGGTCAGACCACGATGACCGTTCCGGGCGGCGTCGAGGTGCCGGTGGAA
ACCGACGACATCGACCACTTCGGCAACCGCCGCCTGCGTACGGTCGGCGAGCTGATCCAAAACCAGATCCGGGTCGGCATGTCGCGGATG
GAGCGGGTGGTCCGGGAGCGGATGACCACCCAGGACGTGGAGGCGATCACACCGCAGACGTTGATCAACATCCGGCCGGTGGTCGCCGCG
ATCAAGGAGTTCTTCGGCACCAGCCAGCTGAGCCAATTCATGGACCAGAACAACCCGCTGTCGGGGTTGACCCACAAGCGCCGACTGTCG
GCGCTGGGGCCCGGCGGTCTGTCACGTGAGCGTGCCGGGCTGGAGGTCCGCGACGTGCACCCGTCGCACTACGGCCGGATGTGCCCGATC
GAAACCCCTGAGGGGCCCAACATCGGTCTGATCGGCTCGCTGTCGGTGTACGCGCGGGTCAACCCGTTCGGGTTCATCGAAACGCCGTAC
CGCAAGGTGGTCGACGGCGTGGTTAGCGACGAGATCGTGTACCTGACCGCCGACGAGGAGGACCGCCACGTGGTGGCACAGGCCAATTCG
CCGATCGATGCGGACGGTCGCTTCGTCGAGCCGCGCGTGCTGGTCCGCCGCAAGGCGGGCGAGGTGGAGTACGTGCCCTCGTCTGAGGTG
GACTACATGGACGTCTCGCCCCGCCAGATGGTGTCGGTGGCCACCGCGATGATTCCCTTCCTGGAGCACGACGACGCCAACCGTGCCCTC
ATGGGGGCAAACATGCAGCGCCAGGCGGTGCCGCTGGTCCGTAGCGAGGCCCCGCTGGTGGGCACCGGGATGGAGCTGCGCGCGGCGATC
GACGCCGGCGACGTCGTCGTCGCCGAAGAAAGCGGCGTCATCGAGGAGGTGTCGGCCGACTACATCACTGTGATGCACGACAACGGCACC
CGGCGTACCTACCGGATGCGCAAGTTTGCCCGGTCCAACCACGGCACTTGCGCCAACCAGTGCCCCATCGTGGACGCGGGCGACCGAGTC
GAGGCCGGTCAGGTGATCGCCGACGGTCCCTGTACTGACGACGGCGAGATGGCGCTGGGCAAGAACCTGCTGGTGGCCATCATGCCGTGG
GAGGGCCACAACTACGAGGACGCGATCATCCTGTCCAACCGCCTGGTCGAAGAGGACGTGCTCACCTCGATCCACATCGAGGAGCATGAG
ATCGATGCTCGCGACACCAAGCTGGGTGCGGAGGAGATCACCCGCGACATCCCGAACATCTCCGACGAGGTGCTCGCCGACCTGGATGAG
CGGGGCATCGTGCGCATCGGTGCCGAGGTTCGCGACGGGGACATCCTGGTCGGCAAGGTCACCCCGAAGGGTGAGACCGAGCTGACGCCG
GAGGAGCGGCTGCTGCGTGCCATCTTCGGTGAGAAGGCCCGCGAGGTGCGCGACACTTCGCTGAAGGTGCCGCACGGCGAATCCGGCAAG
GTGATCGGCATTCGGGTGTTTTCCCGCGAGGACGAGGACGAGTTGCCGGCCGGTGTCAACGAGCTGGTGCGTGTGTATGTGGCTCAGAAA
CGCAAGATCTCCGACGGTGACAAGCTGGCCGGCCGGCACGGCAACAAGGGCGTGATCGGCAAGATCCTGCCGGTTGAGGACATGCCGTTC
CTTGCCGACGGCACCCCGGTGGACATTATTTTGAACACCCACGGCGTGCCGCGACGGATGAACATCGGCCAGATTTTGGAGACCCACCTG
GGTTGGTGTGCCCACAGCGGCTGGAAGGTCGACGCCGCCAAGGGGGTTCCGGACTGGGCCGCCAGGCTGCCCGACGAACTGCTCGAGGCG
CAGCCGAACGCCATTGTGTCGACGCCGGTGTTCGACGGCGCCCAGGAGGCCGAGCTGCAGGGCCTGTTGTCGTGCACGCTGCCCAACCGC
GACGGTGACGTGCTGGTCGACGCCGACGGCAAGGCCATGCTCTTCGACGGGCGCAGCGGCGAGCCGTTCCCGTACCCGGTCACGGTTGGC
TACATGTACATCATGAAGCTGCACCACCTGGTGGACGACAAGATCCACGCCCGCTCCACCGGGCCGTACTCGATGATCACCCAGCAGCCG
CTGGGCGGTAAGGCGCAGTTCGGTGGCCAGCGGTTCGGGGAGATGGAGTGCTGGGCCATGCAGGCCTACGGTGCTGCCTACACCCTGCAG
GAGCTGTTGACCATCAAGTCCGATGACACCGTCGGCCGCGTCAAGGTGTACGAGGCGATCGTCAAGGGTGAGAACATCCCGGAGCCGGGC
ATCCCCGAGTCGTTCAAGGTGCTGCTCAAAGAACTGCAGTCGCTGTGCCTCAACGTCGAGGTGCTATCGAGTGACGGTGCGGCGATCGAA
CTGCGCGAAGGTGAGGACGAGGACCTGGAGCGGGCCGCGGCCAACCTGGGAATCAATCTGTCCCGCAACGAATCCGCAAGTGTCGAGGAT
CTTGCGTAA

Curator Acknowledgements
Curator Description Most Recent Edit