rifapentine [Antibiotic]

Download Sequences


Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3000534
Synonym(s)priftin
DefinitionRifapentine is a semisynthetic rifamycin that inhibits DNA-dependent RNA synthesis. It is often used in the treatment of tuberculosis and leprosy.
SMILESCO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C6CCCC6)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C
PubChem135403821
ChEMBLCHEMBL1660
ChEBI45304
CAS61379-65-5
Drug Classrifamycin antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ rifamycin antibiotic [Drug Class]
Sub-Term(s)
15 ontology terms | Show
+ rifampin ADP-ribosyltransferase (Arr) [AMR Gene Family] confers_resistance_to_antibiotic
+ DnaA confers_resistance_to_antibiotic
+ RbpA confers_resistance_to_antibiotic
+ rpoB2 confers_resistance_to_antibiotic
+ sigma factor conferring resistance to rifampin confers_resistance_to_antibiotic
+ Escherichia coli rpoB mutants conferring resistance to rifampicin confers_resistance_to_antibiotic
+ Mycobacterium leprae rpoB mutations conferring resistance to rifampicin confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin confers_resistance_to_antibiotic
+ Staphylococcus aureus rpoB mutants conferring resistance to rifampicin confers_resistance_to_antibiotic
+ rgt1438 confers_resistance_to_antibiotic
+ iri confers_resistance_to_antibiotic
+ rphB confers_resistance_to_antibiotic
+ rphA confers_resistance_to_antibiotic
+ Streptomyces venezuelae rox confers_resistance_to_antibiotic
+ rifamycin sensitive beta-subunit of RNA polymerase (rpoB) targeted_by_antibiotic
Publications

Floss HG and Yu TW. 2005. Chem Rev 105(2): 621-632. Rifamycin-mode of action, resistance, and biosynthesis. (PMID 15700959)

Curator Acknowledgements
Curator Description Most Recent Edit