rifampin ADP-ribosyltransferase (Arr) [AMR Gene Family]

Accession ARO:3000390
DefinitionEnzyme responsible for the ADP-ribosylative inactivation of rifampin at the 23-OH position using NAD+.
Drug Classrifamycin antibiotic
Resistance Mechanismantibiotic inactivation
Classification7 ontology terms | Show
Parent Term(s)7 ontology terms | Show
+ rifampin inactivation enzyme
+ confers_resistance_to_antibiotic rifabutin [Antibiotic]
+ confers_resistance_to_antibiotic rifampin [Antibiotic]
+ confers_resistance_to_antibiotic rifapentine [Antibiotic]
+ confers_resistance_to_antibiotic rifaximin [Antibiotic]
+ participates_in ADP-ribosylation of antibiotic conferring resistance
+ confers_resistance_to_drug_class rifamycin antibiotic [Drug Class]
7 ontology terms | Show

Quan S, et al. 1999. Antimicrob Agents Chemother 43(1): 181-184. ADP-ribosylation as an intermediate step in inactivation of rifampin by a mycobacterial gene. (PMID 9869590)

Baysarowich J, et al. 2008. Proc Natl Acad Sci U S A 105(12): 4886-4891. Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr. (PMID 18349144)