arr-3

Accession ARO:3002848
Synonym(s)arr-6
CARD Short Namearr-3
Definitionarr-3 is a plasmid-encoded ribosyltransferase found in Vibrio fluvialis.
AMR Gene Familyrifampin ADP-ribosyltransferase (Arr)
Drug Classrifamycin antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesAcinetobacter baumanniig+p+wgs+gi, Acinetobacter defluviip, Acinetobacter haemolyticusp, Acinetobacter johnsoniip+wgs, Acinetobacter juniip+wgs, Acinetobacter lwoffiip+wgs, Acinetobacter nosocomialiswgs, Acinetobacter pittiiwgs, Acinetobacter towneriwgs, Acinetobacter wuhouensiswgs, Aeromonas caviaep+wgs, Aeromonas hydrophilap+wgs, Aeromonas veroniig+wgs+gi, Citrobacter amalonaticusp+wgs, Citrobacter freundiip+wgs, Citrobacter koserip+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniip+wgs, Citrobacter youngaewgs, Comamonas testosteroniwgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia colig+p+wgs+gi, Escherichia fergusoniip+wgs, Klebsiella aerogenesg+p+wgs, Klebsiella huaxiensisg+gi, Klebsiella michiganensisp+wgs, Klebsiella oxytocag+p+wgs, Klebsiella pneumoniaeg+p+wgs+gi, Klebsiella quasipneumoniaep+wgs, Laribacter hongkongensiswgs+gi, Leclercia adecarboxylatap+wgs, Morganella morganiig+p+wgs+gi, Proteus mirabilisg+p+wgs+gi, Proteus penneriwgs, Providencia alcalifaciensg, Providencia rettgerig+p+wgs, Providencia stuartiiwgs, Pseudomonas aeruginosap+wgs+gi, Pseudomonas putidap, Raoultella planticolap+wgs, Salmonella entericag+p+wgs+gi, Serratia marcescenswgs, Shigella flexnerip+wgs, Vibrio alginolyticusg+wgs, Vibrio choleraep+wgs, Vibrio harveyiwgs, Vibrio parahaemolyticusp+wgs
Resistomes with Sequence VariantsAcinetobacter baumanniig+p+wgs+gi, Acinetobacter defluviip, Acinetobacter haemolyticusp, Acinetobacter johnsoniip+wgs, Acinetobacter juniip+wgs, Acinetobacter lwoffiip+wgs, Acinetobacter nosocomialiswgs, Acinetobacter pittiiwgs, Acinetobacter towneriwgs, Acinetobacter wuhouensiswgs, Aeromonas caviaep+wgs, Aeromonas hydrophilap+wgs, Aeromonas veroniig+wgs+gi, Citrobacter amalonaticusp+wgs, Citrobacter freundiip+wgs, Citrobacter koserip+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniip+wgs, Citrobacter youngaewgs, Comamonas testosteroniwgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia colig+p+wgs+gi, Escherichia fergusoniip+wgs, Klebsiella aerogenesg+p+wgs, Klebsiella huaxiensisg+gi, Klebsiella michiganensisp+wgs, Klebsiella oxytocag+p+wgs, Klebsiella pneumoniaeg+p+wgs+gi, Klebsiella quasipneumoniaep+wgs, Laribacter hongkongensiswgs+gi, Leclercia adecarboxylatap+wgs, Morganella morganiig+p+wgs+gi, Proteus mirabilisg+p+wgs+gi, Proteus penneriwgs, Providencia alcalifaciensg, Providencia rettgerig+p+wgs, Providencia stuartiiwgs, Pseudomonas aeruginosap+wgs+gi, Pseudomonas putidap, Raoultella planticolap+wgs, Salmonella entericag+p+wgs+gi, Serratia marcescenswgs, Shigella flexnerip+wgs, Vibrio alginolyticusg+wgs, Vibrio choleraep+wgs, Vibrio harveyiwgs, Vibrio parahaemolyticusp+wgs
Classification13 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic rifampin [Antibiotic]
+ rifampin ADP-ribosyltransferase (Arr) [AMR Gene Family]
Publications

Chowdhury G, et al. 2011. Int J Antimicrob Agents 38(2): 169-173. Transferable plasmid-mediated quinolone resistance in association with extended-spectrum beta-lactamases and fluoroquinolone-acetylating aminoglycoside-6'-N-acetyltransferase in clinical isolates of Vibrio fluvialis. (PMID 21683552)

Resistomes

Prevalence of arr-3 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Acinetobacter baumannii0.35%0.42%0.2%0.63%0%
Acinetobacter defluvii0%12.5%0%0%0%
Acinetobacter haemolyticus0%2.44%0%0%0%
Acinetobacter johnsonii0%2.78%12.73%0%0%
Acinetobacter junii0%33.33%2.99%0%0%
Acinetobacter lwoffii0%1.39%2.63%0%0%
Acinetobacter nosocomialis0%0%2.3%0%0%
Acinetobacter pittii0%0%0.57%0%0%
Acinetobacter towneri0%0%3.85%0%0%
Acinetobacter wuhouensis0%0%50%0%0%
Aeromonas caviae0%2.6%5.38%0%0%
Aeromonas hydrophila0%1.3%0.81%0%0%
Aeromonas veronii3.64%0%2.25%12.5%0%
Citrobacter amalonaticus0%8.33%10.91%0%0%
Citrobacter freundii0%8.62%21.47%0%0%
Citrobacter koseri0%15%6.31%0%0%
Citrobacter portucalensis0%16.18%17.12%0%0%
Citrobacter werkmanii0%10%7.69%0%0%
Citrobacter youngae0%0%12.5%0%0%
Comamonas testosteroni0%0%7.14%0%0%
Enterobacter asburiae0%0.55%2.77%0%0%
Enterobacter chengduensis0%0%4%0%0%
Enterobacter cloacae0%1.12%4.15%0%0%
Enterobacter hormaechei0.72%1.67%8.76%0%0%
Enterobacter kobei0%2.07%3.93%0%0%
Enterobacter roggenkampii0%0.48%2.52%0%0%
Escherichia coli0.29%0.52%1.96%0.26%0%
Escherichia fergusonii0%0.71%2.17%0%0%
Klebsiella aerogenes2%4.35%2.26%0%0%
Klebsiella huaxiensis100%0%0%50%0%
Klebsiella michiganensis0%10.29%6.65%0%0%
Klebsiella oxytoca2.56%2.74%2.1%0%0%
Klebsiella pneumoniae0.3%2.52%7.44%1.9%0%
Klebsiella quasipneumoniae0%2.97%10%0%0%
Laribacter hongkongensis0%0%8.33%50%0%
Leclercia adecarboxylata0%4.76%4.65%0%0%
Morganella morganii19.23%10%12.27%15.38%0%
Proteus mirabilis39.45%10%20.79%25.93%0%
Proteus penneri0%0%25%0%0%
Providencia alcalifaciens18.18%0%0%0%0%
Providencia rettgeri11.76%5.41%5.1%0%0%
Providencia stuartii0%0%6.82%0%0%
Pseudomonas aeruginosa0%0.88%0.44%4.17%0%
Pseudomonas putida0%4%0%0%0%
Raoultella planticola0%13.95%12.82%0%0%
Salmonella enterica1.14%3.45%2.12%2.65%0%
Serratia marcescens0%0%1.05%0%0%
Shigella flexneri0%2.41%0.78%0%0%
Vibrio alginolyticus1.23%0%1.59%0%0%
Vibrio cholerae0%5.26%0.13%0%0%
Vibrio harveyi0%0%4%0%0%
Vibrio parahaemolyticus0%0.62%0.05%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 250


>gb|ACD56151.1|+|arr-3 [Escherichia coli]
MVKDWIPISHDNYKQVQGPFYHGTKANLAIGDLLTTGFISHFEDGRILKHIYFSALMEPAVWGAELAMSLSGLEGRGYIYIVEPTGPFED
DPNLTNKRFPGNPTQSYRTCEPLRIVGVVEDWEGHPVELIRGMLDSLEDLKRRGLHVIED


>gb|EU675686.1|+|1957-2409|arr-3 [Escherichia coli]
ATGGTAAAAGATTGGATTCCCATCTCTCATGATAATTACAAGCAGGTGCAAGGACCGTTCTATCATGGAACCAAAGCCAATTTGGCGATT
GGTGACTTGCTAACCACAGGGTTCATCTCTCATTTCGAGGACGGTCGTATTCTTAAGCACATCTACTTTTCAGCCTTGATGGAGCCAGCA
GTTTGGGGAGCTGAACTTGCTATGTCACTGTCTGGCCTCGAGGGTCGCGGCTACATATACATAGTTGAGCCAACAGGACCGTTCGAAGAC
GATCCGAATCTTACGAACAAAAGATTTCCCGGTAATCCAACACAGTCCTATAGAACCTGCGAACCCTTGAGAATTGTTGGCGTTGTTGAA
GACTGGGAGGGGCATCCTGTTGAATTAATAAGGGGAATGTTGGATTCGTTGGAGGACTTAAAGCGCCGTGGTTTACACGTCATTGAAGAC
TAG

Curator Acknowledgements
Curator Description Most Recent Edit