| Accession | ARO:3002848 |
| Synonym(s) | arr-6 |
| CARD Short Name | arr-3 |
| Definition | arr-3 is a plasmid-encoded ribosyltransferase found in Vibrio fluvialis. |
| AMR Gene Family | rifampin ADP-ribosyltransferase (Arr) |
| Drug Class | rifamycin antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter baumanniig+p+wgs+gi, Acinetobacter defluviip, Acinetobacter haemolyticusp, Acinetobacter johnsoniip+wgs, Acinetobacter juniip+wgs, Acinetobacter lwoffiip+wgs, Acinetobacter nosocomialiswgs, Acinetobacter pittiiwgs, Acinetobacter towneriwgs, Acinetobacter wuhouensiswgs, Aeromonas caviaep+wgs, Aeromonas hydrophilap+wgs, Aeromonas veroniig+wgs+gi, Citrobacter amalonaticusp+wgs, Citrobacter freundiip+wgs, Citrobacter koserip+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniip+wgs, Citrobacter youngaewgs, Comamonas testosteroniwgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia colig+p+wgs+gi, Escherichia fergusoniip+wgs, Klebsiella aerogenesg+p+wgs, Klebsiella huaxiensisg+gi, Klebsiella michiganensisp+wgs, Klebsiella oxytocag+p+wgs, Klebsiella pneumoniaeg+p+wgs+gi, Klebsiella quasipneumoniaep+wgs, Laribacter hongkongensiswgs+gi, Leclercia adecarboxylatap+wgs, Morganella morganiig+p+wgs+gi, Proteus mirabilisg+p+wgs+gi, Proteus penneriwgs, Providencia alcalifaciensg, Providencia rettgerig+p+wgs, Providencia stuartiiwgs, Pseudomonas aeruginosap+wgs+gi, Pseudomonas putidap, Raoultella planticolap+wgs, Salmonella entericag+p+wgs+gi, Serratia marcescenswgs, Shigella flexnerip+wgs, Vibrio alginolyticusg+wgs, Vibrio choleraep+wgs, Vibrio harveyiwgs, Vibrio parahaemolyticusp+wgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+p+wgs+gi, Acinetobacter defluviip, Acinetobacter haemolyticusp, Acinetobacter johnsoniip+wgs, Acinetobacter juniip+wgs, Acinetobacter lwoffiip+wgs, Acinetobacter nosocomialiswgs, Acinetobacter pittiiwgs, Acinetobacter towneriwgs, Acinetobacter wuhouensiswgs, Aeromonas caviaep+wgs, Aeromonas hydrophilap+wgs, Aeromonas veroniig+wgs+gi, Citrobacter amalonaticusp+wgs, Citrobacter freundiip+wgs, Citrobacter koserip+wgs, Citrobacter portucalensisp+wgs, Citrobacter werkmaniip+wgs, Citrobacter youngaewgs, Comamonas testosteroniwgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiip+wgs, Escherichia colig+p+wgs+gi, Escherichia fergusoniip+wgs, Klebsiella aerogenesg+p+wgs, Klebsiella huaxiensisg+gi, Klebsiella michiganensisp+wgs, Klebsiella oxytocag+p+wgs, Klebsiella pneumoniaeg+p+wgs+gi, Klebsiella quasipneumoniaep+wgs, Laribacter hongkongensiswgs+gi, Leclercia adecarboxylatap+wgs, Morganella morganiig+p+wgs+gi, Proteus mirabilisg+p+wgs+gi, Proteus penneriwgs, Providencia alcalifaciensg, Providencia rettgerig+p+wgs, Providencia stuartiiwgs, Pseudomonas aeruginosap+wgs+gi, Pseudomonas putidap, Raoultella planticolap+wgs, Salmonella entericag+p+wgs+gi, Serratia marcescenswgs, Shigella flexnerip+wgs, Vibrio alginolyticusg+wgs, Vibrio choleraep+wgs, Vibrio harveyiwgs, Vibrio parahaemolyticusp+wgs |
| Classification | 13 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + rifamycin antibiotic [Drug Class] + antibiotic inactivation enzyme + rifampin inactivation enzyme + rifampin [Antibiotic] + rifabutin [Antibiotic] + rifaximin [Antibiotic] + rifapentine [Antibiotic] + ADP-ribosylation of antibiotic conferring resistance |
| Parent Term(s) | 2 ontology terms | Show + rifampin ADP-ribosyltransferase (Arr) [AMR Gene Family] + confers_resistance_to_antibiotic rifampin [Antibiotic] |
| Publications | Chowdhury G, et al. 2011. Int J Antimicrob Agents 38(2): 169-173. Transferable plasmid-mediated quinolone resistance in association with extended-spectrum beta-lactamases and fluoroquinolone-acetylating aminoglycoside-6'-N-acetyltransferase in clinical isolates of Vibrio fluvialis. (PMID 21683552) |
Prevalence of arr-3 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0.35% | 0.42% | 0.2% | 0.63% |
| Acinetobacter defluvii | 0% | 12.5% | 0% | 0% |
| Acinetobacter haemolyticus | 0% | 2.44% | 0% | 0% |
| Acinetobacter johnsonii | 0% | 2.78% | 9.09% | 0% |
| Acinetobacter junii | 0% | 33.33% | 2.99% | 0% |
| Acinetobacter lwoffii | 0% | 1.39% | 2.63% | 0% |
| Acinetobacter nosocomialis | 0% | 0% | 2.3% | 0% |
| Acinetobacter pittii | 0% | 0% | 0.57% | 0% |
| Acinetobacter towneri | 0% | 0% | 3.85% | 0% |
| Acinetobacter wuhouensis | 0% | 0% | 50% | 0% |
| Aeromonas caviae | 0% | 2.6% | 3.76% | 0% |
| Aeromonas hydrophila | 0% | 1.3% | 0.81% | 0% |
| Aeromonas veronii | 3.64% | 0% | 1.69% | 12.5% |
| Citrobacter amalonaticus | 0% | 8.33% | 5.45% | 0% |
| Citrobacter freundii | 0% | 8.62% | 12.57% | 0% |
| Citrobacter koseri | 0% | 15% | 6.31% | 0% |
| Citrobacter portucalensis | 0% | 16.18% | 15.32% | 0% |
| Citrobacter werkmanii | 0% | 10% | 7.69% | 0% |
| Citrobacter youngae | 0% | 0% | 12.5% | 0% |
| Comamonas testosteroni | 0% | 0% | 7.14% | 0% |
| Enterobacter asburiae | 0% | 0.55% | 2.77% | 0% |
| Enterobacter chengduensis | 0% | 0% | 4% | 0% |
| Enterobacter cloacae | 0% | 1.12% | 3.51% | 0% |
| Enterobacter hormaechei | 0.72% | 1.67% | 5.44% | 0% |
| Enterobacter kobei | 0% | 2.07% | 3.06% | 0% |
| Enterobacter roggenkampii | 0% | 0.48% | 2.16% | 0% |
| Escherichia coli | 0.29% | 0.52% | 1.31% | 0.26% |
| Escherichia fergusonii | 0% | 0.71% | 2.17% | 0% |
| Klebsiella aerogenes | 2% | 4.35% | 1.98% | 0% |
| Klebsiella huaxiensis | 100% | 0% | 0% | 50% |
| Klebsiella michiganensis | 0% | 10.29% | 5.85% | 0% |
| Klebsiella oxytoca | 2.56% | 2.74% | 2.1% | 0% |
| Klebsiella pneumoniae | 0.3% | 2.52% | 4.62% | 1.9% |
| Klebsiella quasipneumoniae | 0% | 2.97% | 7.76% | 0% |
| Laribacter hongkongensis | 0% | 0% | 4.17% | 50% |
| Leclercia adecarboxylata | 0% | 4.76% | 4.65% | 0% |
| Morganella morganii | 19.23% | 10% | 6.13% | 15.38% |
| Proteus mirabilis | 39.45% | 11.25% | 6.27% | 25.93% |
| Proteus penneri | 0% | 0% | 25% | 0% |
| Providencia alcalifaciens | 18.18% | 0% | 0% | 0% |
| Providencia rettgeri | 11.76% | 5.41% | 2.55% | 0% |
| Providencia stuartii | 0% | 0% | 4.55% | 0% |
| Pseudomonas aeruginosa | 0% | 0.88% | 0.21% | 4.17% |
| Pseudomonas putida | 0% | 4% | 0% | 0% |
| Raoultella planticola | 0% | 13.95% | 10.26% | 0% |
| Salmonella enterica | 1.14% | 3.45% | 0.88% | 2.65% |
| Serratia marcescens | 0% | 0% | 0.79% | 0% |
| Shigella flexneri | 0% | 2.41% | 0.78% | 0% |
| Vibrio alginolyticus | 1.23% | 0% | 0.79% | 0% |
| Vibrio cholerae | 0% | 5.26% | 0.13% | 0% |
| Vibrio harveyi | 0% | 0% | 4% | 0% |
| Vibrio parahaemolyticus | 0% | 0.62% | 0.05% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 250