Ontology | CARD's Antibiotic Resistance Ontology |
Accession | ARO:3000530 |
Definition | Rifabutin is a semisynthetic rifamycin used in tuberculosis therapy. It inhibits DNA-dependent RNA synthesis. |
SMILES | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(c3C2=O)C2=NC3(CCN(CC(C)C)CC3)NC2=C(NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C4=O |
PubChem | 135398743 |
ChEMBL | CHEMBL444633 |
ChEBI | 45367 |
CAS | 72559-06-9 |
Drug Class | rifamycin antibiotic |
Classification | 2 ontology terms | Show |
Parent Term(s) | 1 ontology terms | Show + rifamycin antibiotic [Drug Class] |
Sub-Term(s) | 18 ontology terms | Show + rifampin ADP-ribosyltransferase (Arr) [AMR Gene Family] confers_resistance_to_antibiotic + DnaA confers_resistance_to_antibiotic + RbpA confers_resistance_to_antibiotic + rpoB2 confers_resistance_to_antibiotic + sigma factor conferring resistance to rifampin confers_resistance_to_antibiotic + Escherichia coli rpoB mutants conferring resistance to rifampicin confers_resistance_to_antibiotic + Mycobacterium leprae rpoB mutations conferring resistance to rifampicin confers_resistance_to_antibiotic + Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin confers_resistance_to_antibiotic + Staphylococcus aureus rpoB mutants conferring resistance to rifampicin confers_resistance_to_antibiotic + rgt1438 confers_resistance_to_antibiotic + iri confers_resistance_to_antibiotic + rphB confers_resistance_to_antibiotic + rphA confers_resistance_to_antibiotic + rifampicin resistant rpoC [AMR Gene Family] confers_resistance_to_antibiotic + Mycobacterium tuberculosis rpoC mutations confer resistance to rifampicin confers_resistance_to_antibiotic + Mycobacterium tuberculosis ponA1 mutations conferring resistance to rifabutin confers_resistance_to_antibiotic + HelR confers_resistance_to_antibiotic + rifamycin sensitive beta-subunit of RNA polymerase (rpoB) targeted_by_antibiotic |
Publications | Floss HG and Yu TW. 2005. Chem Rev 105(2): 621-632. Rifamycin-mode of action, resistance, and biosynthesis. (PMID 15700959) |
Curator | Description | Most Recent Edit |
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