rifabutin [Antibiotic]

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3000530
DefinitionRifabutin is a semisynthetic rifamycin used in tuberculosis therapy. It inhibits DNA-dependent RNA synthesis.
SMILESCO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(c3C2=O)C2=NC3(CCN(CC(C)C)CC3)NC2=C(NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C4=O
PubChem135398743
ChEMBLCHEMBL444633
ChEBI45367
CAS72559-06-9
Drug Classrifamycin antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ rifamycin antibiotic [Drug Class]
Sub-Term(s)
18 ontology terms | Show
+ rifampin ADP-ribosyltransferase (Arr) [AMR Gene Family] confers_resistance_to_antibiotic
+ DnaA confers_resistance_to_antibiotic
+ RbpA confers_resistance_to_antibiotic
+ rpoB2 confers_resistance_to_antibiotic
+ sigma factor conferring resistance to rifampin confers_resistance_to_antibiotic
+ Escherichia coli rpoB mutants conferring resistance to rifampicin confers_resistance_to_antibiotic
+ Mycobacterium leprae rpoB mutations conferring resistance to rifampicin confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis rpoB with mutations conferring resistance to rifampicin confers_resistance_to_antibiotic
+ Staphylococcus aureus rpoB mutants conferring resistance to rifampicin confers_resistance_to_antibiotic
+ rgt1438 confers_resistance_to_antibiotic
+ iri confers_resistance_to_antibiotic
+ rphB confers_resistance_to_antibiotic
+ rphA confers_resistance_to_antibiotic
+ rifampicin resistant rpoC [AMR Gene Family] confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis rpoC mutations confer resistance to rifampicin confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis ponA1 mutations conferring resistance to rifabutin confers_resistance_to_antibiotic
+ HelR confers_resistance_to_antibiotic
+ rifamycin sensitive beta-subunit of RNA polymerase (rpoB) targeted_by_antibiotic
Publications

Floss HG and Yu TW. 2005. Chem Rev 105(2): 621-632. Rifamycin-mode of action, resistance, and biosynthesis. (PMID 15700959)

Curator Acknowledgements
Curator Description Most Recent Edit