| Accession | ARO:3000245 |
| CARD Short Name | RbpA |
| Definition | RNA-polymerase binding protein which confers resistance to rifampin. |
| AMR Gene Family | RbpA bacterial RNA polymerase-binding protein |
| Drug Class | rifamycin antibiotic |
| Resistance Mechanism | antibiotic target protection |
| Resistomes with Sequence Variants | Mycobacterium aviumg+wgs, Mycobacterium colombienseg+wgs, Mycobacterium intracellulareg+wgs, Mycobacterium kansasiig+wgs, Mycobacterium lepraeg+wgs, Mycobacterium lepromatosisg+wgs, Mycobacterium marinumg+wgs, Mycobacterium tuberculosisg+wgs, Mycobacterium ulceransg+wgs, Mycolicibacterium fortuitumg+wgs, Mycolicibacterium septicumg+wgs, Rhodococcus pyridinivoransg+wgs+gi, Rhodococcus rhodochrousg+wgs+gi, Streptococcus lutetiensiswgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic target protection [Resistance Mechanism] + antibiotic molecule + antibiotic target protection protein + rifamycin antibiotic [Drug Class] + rifampin-resistant RNA polymerase-binding protein |
| Parent Term(s) | 5 ontology terms | Show + confers_resistance_to_antibiotic rifabutin [Antibiotic] + confers_resistance_to_antibiotic rifampin [Antibiotic] + confers_resistance_to_antibiotic rifapentine [Antibiotic] + confers_resistance_to_antibiotic rifaximin [Antibiotic] + RbpA bacterial RNA polymerase-binding protein [AMR Gene Family] |
| Publications | Newell KV, et al. 2006. Mol Microbiol 60(3): 687-696. The RNA polymerase-binding protein RbpA confers basal levels of rifampicin resistance on Streptomyces coelicolor. (PMID 16629670) Dey A, et al. 2011. Microbiology 157(PT 7): 2056-2071. Molecular insights into the mechanism of phenotypic tolerance to rifampicin conferred on mycobacterial RNA polymerase by MsRbpA. (PMID 21415119) |
Prevalence of RbpA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Mycobacterium avium | 100% | 0% | 91.39% | 0% |
| Mycobacterium colombiense | 100% | 0% | 100% | 0% |
| Mycobacterium intracellulare | 100% | 0% | 73.47% | 0% |
| Mycobacterium kansasii | 100% | 0% | 100% | 0% |
| Mycobacterium leprae | 100% | 0% | 100% | 0% |
| Mycobacterium lepromatosis | 100% | 0% | 100% | 0% |
| Mycobacterium marinum | 100% | 0% | 86.79% | 0% |
| Mycobacterium tuberculosis | 100% | 0% | 72.88% | 0% |
| Mycobacterium ulcerans | 100% | 0% | 100% | 0% |
| Mycolicibacterium fortuitum | 100% | 0% | 93.1% | 0% |
| Mycolicibacterium septicum | 100% | 0% | 100% | 0% |
| Rhodococcus pyridinivorans | 100% | 0% | 91.67% | 100% |
| Rhodococcus rhodochrous | 100% | 0% | 88.89% | 100% |
| Streptococcus lutetiensis | 0% | 0% | 2.04% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 200