RbpA bacterial RNA polymerase-binding protein [AMR Gene Family]

Accession ARO:3004243
DefinitionRbpA is a family of bacterial RNA polymerase-binding proteins, which acts as a transcription factor and binds to the sigma subunit of RNA polymerase.
Drug Classrifamycin antibiotic
Resistance Mechanismantibiotic target protection
Classification6 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ rifampin-resistant RNA polymerase-binding protein
+ confers_resistance_to_drug_class rifamycin antibiotic [Drug Class]
1 ontology terms | Show
+ RbpA

Newell KV, et al. 2006. Mol Microbiol 60(3): 687-696. The RNA polymerase-binding protein RbpA confers basal levels of rifampicin resistance on Streptomyces coelicolor. (PMID 16629670)

Hu Y, et al. 2012. Nucleic Acids Res. 40(14):6547-57 Mycobacterium tuberculosis RbpA protein is a new type of transcriptional activator that stabilizes the σ A-containing RNA polymerase holoenzyme. (PMID 22570422)