rifampin [Antibiotic]

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Accession ARO:3000169
Synonym(s)rifampicin
DefinitionRifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections.
Drug Classrifamycin antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ rifamycin antibiotic [Drug Class]
Sub-Term(s)
20 ontology terms | Show
+ rifampin ADP-ribosyltransferase (Arr) [AMR Gene Family] confers_resistance_to_antibiotic
+ DnaA confers_resistance_to_antibiotic
+ RbpA confers_resistance_to_antibiotic
+ rpoB2 confers_resistance_to_antibiotic
+ sigma factor conferring resistance to rifampin confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis embB with mutation conferring resistance to rifampicin confers_resistance_to_antibiotic
+ Escherichia coli rpoB mutants conferring resistance to rifampicin confers_resistance_to_antibiotic
+ Mycobacterium leprae rpoB mutations conferring resistance to rifampicin confers_resistance_to_antibiotic
+ Mycobacterium tuberculosis rpoB mutants conferring resistance to rifampicin confers_resistance_to_antibiotic
+ Staphylococcus aureus rpoB mutants conferring resistance to rifampicin confers_resistance_to_antibiotic
+ EfrAB confers_resistance_to_antibiotic
+ efpA confers_resistance_to_antibiotic
+ AcrAB-TolC confers_resistance_to_antibiotic
+ AdeIJK confers_resistance_to_antibiotic
+ rgt1438 confers_resistance_to_antibiotic
+ iri confers_resistance_to_antibiotic
+ rphB confers_resistance_to_antibiotic
+ rphA confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnEF confers_resistance_to_antibiotic
+ rifamycin sensitive beta-subunit of RNA polymerase (rpoB) targeted_by_antibiotic
Publications

Huang DB and DuPont HL. 2005. J Infect 50(2): 97-106. Rifaximin--a novel antimicrobial for enteric infections. (PMID 15667909)

Wehrli W. 1983. Rev Infect Dis 5(SUPPL 3): S407-S411. Rifampin: mechanisms of action and resistance. (PMID 6356275)