| Accession | ARO:3000169 |
| Synonym(s) | rifampicin |
| Definition | Rifampin is a semi-synthetic rifamycin, and inhibits RNA synthesis by binding to RNA polymerase. Rifampin is the mainstay agent for the treatment of tuberculosis, leprosy and complicated Gram-positive infections. |
| Drug Class | rifamycin antibiotic |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + rifamycin antibiotic [Drug Class] |
| Sub-Term(s) | 42 ontology terms | Show + rifampin ADP-ribosyltransferase (Arr) [AMR Gene Family] confers_resistance_to_antibiotic + DnaA confers_resistance_to_antibiotic + RbpA confers_resistance_to_antibiotic + rpoB2 confers_resistance_to_antibiotic + sigma factor conferring resistance to rifampin confers_resistance_to_antibiotic + Mycobacterium tuberculosis embB with mutation conferring resistance to rifampicin confers_resistance_to_antibiotic + Escherichia coli rpoB mutants conferring resistance to rifampicin confers_resistance_to_antibiotic + Mycobacterium leprae rpoB mutations conferring resistance to rifampicin confers_resistance_to_antibiotic + Mycobacterium tuberculosis rpoB mutations conferring resistance to rifampicin confers_resistance_to_antibiotic + Staphylococcus aureus rpoB mutants conferring resistance to rifampicin confers_resistance_to_antibiotic + EfrAB confers_resistance_to_antibiotic + efpA confers_resistance_to_antibiotic + AcrAB-TolC confers_resistance_to_antibiotic + AdeIJK confers_resistance_to_antibiotic + rgt1438 confers_resistance_to_antibiotic + iri confers_resistance_to_antibiotic + rphB confers_resistance_to_antibiotic + rphA confers_resistance_to_antibiotic + Klebsiella pneumoniae KpnEF confers_resistance_to_antibiotic + rifampicin resistant rpoC [AMR Gene Family] confers_resistance_to_antibiotic + Mycobacterium tuberculosis rpoC mutations confer resistance to rifampicin confers_resistance_to_antibiotic + Mycobacterium tuberculosis ponA1 mutations confer resistance to rifabutin confers_resistance_to_antibiotic + rifampicin resistant rpoA [AMR Gene Family] confers_resistance_to_antibiotic + Bacillus subtilis rpoB mutants conferring resistance to rifampin confers_resistance_to_antibiotic + Bifidobacterium adolescentis rpoB mutants conferring resistance to rifampicin confers_resistance_to_antibiotic + Clostridioides difficile rpoB with mutation conferring resistance to rifampicin confers_resistance_to_antibiotic + Helicobacter pylori rpoB mutation conferring resistance to rifampicin confers_resistance_to_antibiotic + arr-1 confers_resistance_to_antibiotic + arr-2 confers_resistance_to_antibiotic + arr-3 confers_resistance_to_antibiotic + arr-4 confers_resistance_to_antibiotic + arr-5 confers_resistance_to_antibiotic + arr-7 confers_resistance_to_antibiotic + arr-8 confers_resistance_to_antibiotic + Mycobacterium tuberculosis rpoA mutations confer resistance to rifampicin confers_resistance_to_antibiotic + YajC confers_resistance_to_antibiotic + HelR confers_resistance_to_antibiotic + Streptomyces venezuelae rox confers_resistance_to_antibiotic + Nocardia farcinica rox confers_resistance_to_antibiotic + LptD confers_resistance_to_antibiotic + Vibrio vulnificus rpoB mutants conferring resistance to rifampin confers_resistance_to_antibiotic + rifamycin sensitive beta-subunit of RNA polymerase (rpoB) targeted_by_antibiotic |
| Publications | Huang DB and DuPont HL. 2005. J Infect 50(2): 97-106. Rifaximin--a novel antimicrobial for enteric infections. (PMID 15667909) Wehrli W. 1983. Rev Infect Dis 5(SUPPL 3): S407-S411. Rifampin: mechanisms of action and resistance. (PMID 6356275) |
