| Accession | ARO:3000384 |
| CARD Short Name | AcrAB-TolC |
| Definition | AcrAB-TolC is a tripartite RND efflux system that confers resistance to tetracycline, chloramphenicol, ampicillin, nalidixic acid, and rifampin in Gram-negative bacteria. The system spans the cell membrane (AcrB) and the outer-membrane (TolC), and is linked together in the periplasm by AcrA. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | tetracycline antibiotic, disinfecting agents and antiseptics, phenicol antibiotic, rifamycin antibiotic, penam, glycylcycline, cephalosporin, fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Classification | 15 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + beta-lactam antibiotic + mechanism of antibiotic resistance + cephem + tetracycline antibiotic [Drug Class] + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + disinfecting agents and antiseptics [Drug Class] + phenicol antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + rifamycin antibiotic [Drug Class] + penam [Drug Class] + glycylcycline [Drug Class] + cephalosporin [Drug Class] |
| Parent Term(s) | 9 ontology terms | Show + confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class] + confers_resistance_to_antibiotic tigecycline [Antibiotic] + confers_resistance_to_antibiotic tetracycline [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_antibiotic rifampin [Antibiotic] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic ampicillin [Antibiotic] + confers_resistance_to_antibiotic cefalotin [Antibiotic] + confers_resistance_to_antibiotic triclosan [Antibiotic] |
| Sub-Term(s) | 13 ontology terms | Show |
| Publications | Tikhonova EB, et al. 2011. Chem Biol 18(4): 454-463. Sequential Mechanism of Assembly of Multidrug Efflux Pump AcrAB-TolC. (PMID 21513882) Okusu H, et al. 1996. J Bacteriol 178(1): 306-308. AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. (PMID 8550435) |
Prevalence of AcrAB-TolC among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Name: AcrAB-TolC
Model Description: E. coli AcrAB-TolC model includes all components of the efflux pump system, including all of its known regulators (AcrR, MarA, RobA, SoxS, MarR, SdiA).
Escherichia coli marR mutant conferring antibiotic resistancemarAAcrSTolCacrBsdiAEscherichia coli soxS with mutation conferring antibiotic resistanceEscherichia coli acrR with mutation conferring multidrug antibiotic resistanceEscherichia coli acrAEscherichia coli rob