Accession ARO:3000824
DefinitionRamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, rifamycin antibiotic, glycylcycline, penam, phenicol antibiotic, disinfecting agents and antiseptics, cephalosporin, fluoroquinolone antibiotic
Resistance Mechanismantibiotic efflux, antibiotic target alteration
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Efflux Regulatorprotein(s) and two-component regulatory system modulating antibiotic efflux
Classification27 ontology terms | Show
Parent Term(s)3 ontology terms | Show
2 ontology terms | Show

Kehrenberg C, et al. 2009. J Antimicrob Chemother 64(6): 1175-1180. Decreased fluoroquinolone susceptibility in mutants of Salmonella serovars other than Typhimurium: detection of novel mutations involved in modulated expression of ramA and soxS. (PMID 19778917)

Ricci V and Piddock LJ. 2009. J Antimicrob Chemother 63(5): 909-916. Ciprofloxacin selects for multidrug resistance in Salmonella enterica serovar Typhimurium mediated by at least two different pathways. (PMID 19270312)

Abouzeed YM, et al. 2008. Antimicrob Agents Chemother 52(7): 2428-2434. ramR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium. (PMID 18443112)

O'Regan E, et al. 2009. Antimicrob Agents Chemother 53(3): 1080-1087. Multiple regulatory pathways associated with high-level ciprofloxacin and multidrug resistance in Salmonella enterica serovar enteritidis: involvement of RamA and other global regulators. (PMID 19104017)