| Accession | ARO:3000824 |
| Definition | RamR is a repressor that regulates RamA expression. Mutations lead to the upregulation of AcrAB, which is positively regulated by RamA. |
| AMR Gene Family | resistance-nodulation-cell division (RND) antibiotic efflux pump |
| Drug Class | tetracycline antibiotic, penicillin beta-lactam, cephalosporin, disinfecting agents and antiseptics, phenicol antibiotic, rifamycin antibiotic, glycylcycline, fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic efflux, antibiotic target alteration |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Efflux Regulator | protein(s) and two-component regulatory system modulating antibiotic efflux |
| Classification | 28 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + beta-lactam antibiotic + mechanism of antibiotic resistance + tetracycline antibiotic [Drug Class] + penicillin beta-lactam [Drug Class] + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + antibiotic target alteration [Resistance Mechanism] + cephalosporin [Drug Class] + penicillin with extended spectrum + first-generation cephalosporin + disinfecting agents and antiseptics [Drug Class] + phenicol antibiotic [Drug Class] + mutation conferring antibiotic resistance + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + rifamycin antibiotic [Drug Class] + glycylcycline [Drug Class] + triclosan [Antibiotic] + cefalotin [Antibiotic] + ampicillin [Antibiotic] + chloramphenicol [Antibiotic] + rifampin [Antibiotic] + resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] + tetracycline [Antibiotic] + antibiotic resistant gene variant or mutant + tigecycline [Antibiotic] + fluoroquinolone antibiotic [Drug Class] |
| Parent Term(s) | 3 ontology terms | Show |
| Sub-Term(s) | 2 ontology terms | Show |
| Publications | Kehrenberg C, et al. 2009. J Antimicrob Chemother 64(6): 1175-1180. Decreased fluoroquinolone susceptibility in mutants of Salmonella serovars other than Typhimurium: detection of novel mutations involved in modulated expression of ramA and soxS. (PMID 19778917) Ricci V and Piddock LJ. 2009. J Antimicrob Chemother 63(5): 909-916. Ciprofloxacin selects for multidrug resistance in Salmonella enterica serovar Typhimurium mediated by at least two different pathways. (PMID 19270312) Abouzeed YM, et al. 2008. Antimicrob Agents Chemother 52(7): 2428-2434. ramR mutations involved in efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium. (PMID 18443112) O'Regan E, et al. 2009. Antimicrob Agents Chemother 53(3): 1080-1087. Multiple regulatory pathways associated with high-level ciprofloxacin and multidrug resistance in Salmonella enterica serovar enteritidis: involvement of RamA and other global regulators. (PMID 19104017) |
| Curator | Description | Most Recent Edit |
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