tigecycline [Antibiotic]

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Accession ARO:0000030
Synonym(s)Tygacil
DefinitionTigecycline is an glycylcycline antibiotic. It works by inhibiting action of the prokaryotic 30S ribosome.
Drug Classtetracycline antibiotic, glycylcycline
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ glycylcycline [Drug Class]
Sub-Term(s)
9 ontology terms | Show
+ antibiotic sensitive 16S rRNA targeted_by_antibiotic
+ AdeABC confers_resistance_to_antibiotic
+ tetX confers_resistance_to_antibiotic
+ oqxAB confers_resistance_to_antibiotic
+ AcrAB-TolC confers_resistance_to_antibiotic
+ Acinetobacter baumannii AbuO confers_resistance_to_antibiotic
+ tet(A) confers_resistance_to_antibiotic
+ Tet(X3) confers_resistance_to_antibiotic
+ Tet(X4) confers_resistance_to_antibiotic
Publications

Chopra I and Roberts M. 2001. Microbiol Mol Biol Rev 65(2): 232-260. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. (PMID 11381101)

Thaker M, et al. 2010. Cell Mol Life Sci 67(3): 419-431. The tetracycline resistome. (PMID 19862477)