Accession ARO:3000770
DefinitionAdeABC is an RND multidrug efflux system in Acinetobacter species, notably A. baunmannii. AdeA is a membrane fusion protein, AdeB is the inner membrane transporter, and AdeC is the outer membrane factor. It confers resistance to tigecycline.
AMR Gene Familyresistance-nodulation-cell division (RND) antibiotic efflux pump
Drug Classtetracycline antibiotic, glycylcycline
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification8 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic tigecycline [Antibiotic]
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
5 ontology terms | Show
+ adeA part_of
+ adeB part_of
+ adeC part_of
+ adeR regulates
+ adeS regulates

Coyne S, et al. 2011. Antimicrob Agents Chemother 55(3): 947-953. Efflux-mediated antibiotic resistance in Acinetobacter spp. (PMID 21173183)

Ruzin A, et al. 2007. J Antimicrob Chemother 59(5): 1001-1004. AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex. (PMID 17363424)