glycylcycline [Drug Class]

Accession ARO:0000042
DefinitionGlycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA.
Drug Classtetracycline antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
5 ontology terms | Show
+ tigecycline [Antibiotic]
+ 30S ribosomal subunit targeted_by
+ multidrug and toxic compound extrusion (MATE) transporter [AMR Gene Family] confers_resistance_to_drug_class
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] confers_resistance_to_drug_class
+ resistance-nodulation-cell division (RND) antibiotic efflux pump [AMR Gene Family] confers_resistance_to_drug_class
Publications

Chopra I and Roberts M. 2001. Microbiol Mol Biol Rev 65(2): 232-260. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. (PMID 11381101)