| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:0000042 |
| Definition | Glycylcyclines are a new class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance. Presently, there is only one glycylcycline antibiotic for clinical use: tigecycline. It works by inhibiting action of the prokaryotic 30S ribosome, preventing the binding of aminoacyl-tRNA. |
| Drug Class | tetracycline antibiotic |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + tetracycline antibiotic [Drug Class] |
| Sub-Term(s) | 3 ontology terms | Show + tigecycline [Antibiotic] + 30S ribosomal subunit targeted_by + mepA confers_resistance_to_drug_class |
| Publications | Chopra I and Roberts M. 2001. Microbiol Mol Biol Rev 65(2): 232-260. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. (PMID 11381101) |
| Curator | Description | Most Recent Edit |
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