tetracycline [Antibiotic]

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Accession ARO:0000051
Synonym(s)Abricycline Achromycin Agromicina Ambramicina Ambramycin Biocycline Criseociclina Enterocycline Sumycin Tsiklomistsin
DefinitionTetracycline is a broad-spectrum polyketide antibiotic produced by many Streptomyces. It works by inhibiting action of the prokaryotic 30S ribosome.
SMILESN/A
PubChem54675776
Drug Classtetracycline antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
123 ontology terms | Show
+ antibiotic sensitive 16S rRNA targeted_by_antibiotic
+ EmrKY-TolC confers_resistance_to_antibiotic
+ tap confers_resistance_to_antibiotic
+ MexAB-OprM confers_resistance_to_antibiotic
+ tet(X) confers_resistance_to_antibiotic
+ tet(32) confers_resistance_to_antibiotic
+ tet(36) confers_resistance_to_antibiotic
+ tetB(P) confers_resistance_to_antibiotic
+ tet(Q) confers_resistance_to_antibiotic
+ tet(S) confers_resistance_to_antibiotic
+ tet(T) confers_resistance_to_antibiotic
+ tet(W) confers_resistance_to_antibiotic
+ tet(M) confers_resistance_to_antibiotic
+ tet(O) confers_resistance_to_antibiotic
+ tet(44) confers_resistance_to_antibiotic
+ Escherichia coli 16S rRNA (rrnB) mutation conferring resistance to tetracycline confers_resistance_to_antibiotic
+ Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to tetracycline confers_resistance_to_antibiotic
+ Helicobacter pylori 16S rRNA mutation conferring resistance to tetracycline confers_resistance_to_antibiotic
+ Cutibacterium acnes 16S rRNA mutation conferring resistance to tetracycline confers_resistance_to_antibiotic
+ MexJK-OprM confers_resistance_to_antibiotic
+ MexPQ-OpmE confers_resistance_to_antibiotic
+ MexCD-OprJ confers_resistance_to_antibiotic
+ Corynebacterium striatum tetA confers_resistance_to_antibiotic
+ tet(Z) confers_resistance_to_antibiotic
+ tet(Y) confers_resistance_to_antibiotic
+ tet(V) confers_resistance_to_antibiotic
+ tetA(P) confers_resistance_to_antibiotic
+ tet(L) confers_resistance_to_antibiotic
+ tet(K) confers_resistance_to_antibiotic
+ tet(J) confers_resistance_to_antibiotic
+ tet(H) confers_resistance_to_antibiotic
+ tet(G) confers_resistance_to_antibiotic
+ tet(E) confers_resistance_to_antibiotic
+ tet(D) confers_resistance_to_antibiotic
+ tet(C) confers_resistance_to_antibiotic
+ tet(B) confers_resistance_to_antibiotic
+ tet(A) confers_resistance_to_antibiotic
+ tet(43) confers_resistance_to_antibiotic
+ tet(42) confers_resistance_to_antibiotic
+ tet(41) confers_resistance_to_antibiotic
+ tet(40) confers_resistance_to_antibiotic
+ tet(39) confers_resistance_to_antibiotic
+ tet(38) confers_resistance_to_antibiotic
+ tet(30) confers_resistance_to_antibiotic
+ tet(35) confers_resistance_to_antibiotic
+ tet(33) confers_resistance_to_antibiotic
+ tet(31) confers_resistance_to_antibiotic
+ otr(B) confers_resistance_to_antibiotic
+ tcr3 confers_resistance_to_antibiotic
+ otr(C) confers_resistance_to_antibiotic
+ AdeABC confers_resistance_to_antibiotic
+ AdeFGH confers_resistance_to_antibiotic
+ AcrAB-TolC confers_resistance_to_antibiotic
+ AdeIJK confers_resistance_to_antibiotic
+ MexVW-OprM confers_resistance_to_antibiotic
+ SmeDEF confers_resistance_to_antibiotic
+ ykkCD confers_resistance_to_antibiotic
+ tet(45) confers_resistance_to_antibiotic
+ tetA(58) confers_resistance_to_antibiotic
+ tetB(58) confers_resistance_to_antibiotic
+ tetR(G) confers_resistance_to_antibiotic
+ tetAB(46) confers_resistance_to_antibiotic
+ tetAB(60) confers_resistance_to_antibiotic
+ MexAB-OprM with NalD mutations conferring resistance to multiple antibiotics confers_resistance_to_antibiotic
+ MexCD-OprJ with type B NfxB mutation confers_resistance_to_antibiotic
+ MuxABC-OpmB confers_resistance_to_antibiotic
+ MexAB-OprM with MexR mutations confers resistance to multiple antibiotics confers_resistance_to_antibiotic
+ Escherichia coli mdfA confers_resistance_to_antibiotic
+ Serratia marcescens Omp1 confers_resistance_to_antibiotic
+ tet(37) confers_resistance_to_antibiotic
+ Neisseria gonorrhoeae porin PIB (por) confers_resistance_to_antibiotic
+ tet(34) confers_resistance_to_antibiotic
+ MexXY-OprM confers_resistance_to_antibiotic
+ MexXY-OprA confers_resistance_to_antibiotic
+ MexGHI-OpmD confers_resistance_to_antibiotic
+ MexAB-OprM with NalC mutations conferring resistance to aztreonam confers_resistance_to_antibiotic
+ MexAB-OprM with CpxR regulator conferring resistance to ciprofloxacin, ceftazidime, and aztreonam confers_resistance_to_antibiotic
+ hp1181 confers_resistance_to_antibiotic
+ tet(W/N/W) confers_resistance_to_antibiotic
+ tet(59) confers_resistance_to_antibiotic
+ poxtA confers_resistance_to_antibiotic
+ Klebsiella pneumoniae KpnEF confers_resistance_to_antibiotic
+ tet(X3) confers_resistance_to_antibiotic
+ tet(X4) confers_resistance_to_antibiotic
+ hp1184 confers_resistance_to_antibiotic
+ mdeA confers_resistance_to_antibiotic
+ hp1165 confers_resistance_to_antibiotic
+ VAM-1 confers_resistance_to_antibiotic
+ tet(O/32/O) confers_resistance_to_antibiotic
+ tet(O/M/O) confers_resistance_to_antibiotic
+ tet(O/W) confers_resistance_to_antibiotic
+ tet(O/W/32/O) confers_resistance_to_antibiotic
+ tet(O/W/O) confers_resistance_to_antibiotic
+ tet(W/32/O) confers_resistance_to_antibiotic
+ Streptomyces lividans otr(A) confers_resistance_to_antibiotic
+ PvrR confers_resistance_to_antibiotic
+ rpsJ confers_resistance_to_antibiotic
+ tet(47) confers_resistance_to_antibiotic
+ tet(48) confers_resistance_to_antibiotic
+ tet(49) confers_resistance_to_antibiotic
+ tet(50) confers_resistance_to_antibiotic
+ tet(51) confers_resistance_to_antibiotic
+ tet(52) confers_resistance_to_antibiotic
+ tet(53) confers_resistance_to_antibiotic
+ tet(54) confers_resistance_to_antibiotic
+ tet(55) confers_resistance_to_antibiotic
+ tet(56) confers_resistance_to_antibiotic
+ tet(57) confers_resistance_to_antibiotic
+ tet(61) confers_resistance_to_antibiotic
+ tet(X1) confers_resistance_to_antibiotic
+ tet(X5) confers_resistance_to_antibiotic
+ tet(X6) confers_resistance_to_antibiotic
+ Escherichia coli AcrAB-TolC with AcrR mutation conferring resistance to ciprofloxacin, tetracycline, and ceftazidime confers_resistance_to_antibiotic
+ Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline confers_resistance_to_antibiotic
+ Enterobacter aerogenes acrR with mutation conferring multidrug antibiotic resistance confers_resistance_to_antibiotic
+ dfrL confers_resistance_to_antibiotic
+ Enterobacter cloacae rob confers_resistance_to_antibiotic
+ tet(62) confers_resistance_to_antibiotic
+ tet(63) confers_resistance_to_antibiotic
+ tet(64) confers_resistance_to_antibiotic
+ lmrP confers_resistance_to_antibiotic
+ aadT confers_resistance_to_antibiotic
+ tet(65) confers_resistance_to_antibiotic
Publications

Chopra I and Roberts M. 2001. Microbiol Mol Biol Rev 65(2): 232-260. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. (PMID 11381101)

Thaker M, et al. 2010. Cell Mol Life Sci 67(3): 419-431. The tetracycline resistome. (PMID 19862477)
Curator Acknowledgements
Curator Description Most Recent Edit