tetB(58)

Accession ARO:3003981
DefinitionTetracycline resistant TetB(58) efflux pump found in Paenibacillus sp. LC231, a strain of Paenibacillus isolated from Lechuguilla Cave, NM, USA. Described by Pawlowski et al. 2016.
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
Publications

Pawlowski AC, et al. 2016. Nat Commun 7:13803 A diverse intrinsic antibiotic resistome from a cave bacterium. (PMID 27929110)

Resistomes

Prevalence of tetB(58) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 500

Type of Antibiotic Resistance: Intrinsic or chromosomally-encoded


>gb|APB03215.1|+|tetB(48) [Paenibacillus sp. LC231]
MSSSMIQPGTERQLKNRTSLGQTVRNSLTMAYRGLLKLRRTPEQLFDVTFQPIIFTLMFTYIFGGAISGDVASYLPVIIPGILVQTVITT
SVVTGVQLREDMDKGVFDRFKSLPIARIAPLAGALLADTIRYTIATVLTFTMGYIMGYRPEGGLGYVALAGLVVILCSWAISWIFAFCGV
IARSASGVQGISMIVLFPLTFLSNAFVPVDTMPGWLQWFVNMNPISHLVTAVRDLTNAGTVGWDLTISLVGAAVIVAIFAPITVRAYMRR
T


>gb|KX531045.1|+|1-816|tetB(48) [Paenibacillus sp. LC231]
ATGAGCAGCTCCATGATTCAGCCTGGGACGGAACGTCAGCTTAAGAACCGCACGAGTTTGGGTCAGACGGTCCGAAATTCGTTGACGATG
GCTTACCGCGGGCTGCTGAAGCTCCGGCGCACGCCCGAGCAGTTGTTTGACGTCACGTTTCAGCCCATTATTTTTACGCTGATGTTCACC
TATATTTTTGGGGGCGCCATCTCGGGTGACGTGGCGAGTTATTTGCCCGTCATCATTCCCGGCATCCTCGTCCAGACCGTGATTACGACC
TCCGTCGTCACAGGCGTTCAGCTGCGCGAGGATATGGATAAAGGCGTATTCGACCGATTCAAATCGCTGCCGATTGCACGCATCGCACCG
CTGGCGGGTGCCCTGCTGGCAGACACGATTCGGTATACCATTGCGACAGTGCTTACCTTTACGATGGGATATATTATGGGGTATCGGCCC
GAGGGCGGCTTGGGTTATGTTGCTCTTGCGGGGTTGGTCGTCATTTTGTGCTCATGGGCCATTAGCTGGATTTTTGCTTTCTGCGGCGTG
ATTGCAAGATCTGCCTCCGGCGTGCAGGGGATATCGATGATCGTGCTGTTTCCGCTCACGTTTCTCTCCAACGCGTTCGTGCCGGTGGAT
ACGATGCCGGGCTGGCTGCAGTGGTTCGTCAATATGAATCCGATCTCGCATCTTGTGACAGCCGTTCGGGATCTCACCAACGCTGGCACC
GTGGGCTGGGATCTCACGATATCCTTGGTTGGCGCCGCGGTTATCGTGGCGATCTTTGCTCCCATTACGGTTCGTGCGTACATGCGCCGC
ACTTGA