major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]

Accession ARO:0010002
Synonym(s)MFS type drug efflux
DefinitionDirected pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification4 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
86 ontology terms | Show
Publications

Li XZ and Nikaido H. 2009. Drugs 69(12): 1555-1623. Efflux-mediated drug resistance in bacteria: an update. (PMID 19678712)

Pao SS, et al. 1998. Microbiol Mol Biol Rev 62(1): 1-34. Major facilitator superfamily. (PMID 9529885)

Saier MH Jr, et al. 1999. J Mol Microbiol Biotechnol 1(2): 257-279. The major facilitator superfamily. (PMID 10943556)