major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]

Accession ARO:0010002
Synonym(s)MFS type drug efflux
DefinitionDirected pumping of antibiotic out of a cell to confer resistance. Major facilitator superfamily (MFS) transporters and ABC transporters comprise the two largest and most functionally diverse of the transporter superfamilies. However, MFS transporters are distinct from ABC transporters in both their primary sequence and structure and in the mechanism of energy coupling. As secondary transporters they are, like RND and SMR transporters, energized by the electrochemical proton gradient.
Drug Classtetracycline antibiotic, fluoroquinolone antibiotic, glycylcycline, acridine dye, peptide antibiotic, penam, cephalosporin, macrolide antibiotic, antibacterial free fatty acids, nucleoside antibiotic, lincosamide antibiotic, phenicol antibiotic, benzalkonium chloride, rhodamine, fosfomycin, bicyclomycin, isoniazid, rifamycin antibiotic, nitroimidazole antibiotic, oxazolidinone antibiotic, diaminopyrimidine antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification9 ontology terms | Show
Parent Term(s)22 ontology terms | Show
+ efflux pump complex or subunit conferring antibiotic resistance [Efflux Component]
+ confers_resistance_to_drug_class fluoroquinolone antibiotic [Drug Class]
+ confers_resistance_to_drug_class tetracycline antibiotic [Drug Class]
+ confers_resistance_to_drug_class glycylcycline [Drug Class]
+ confers_resistance_to_drug_class acridine dye [Drug Class]
+ confers_resistance_to_drug_class peptide antibiotic [Drug Class]
+ confers_resistance_to_drug_class penam [Drug Class]
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
+ confers_resistance_to_drug_class macrolide antibiotic [Drug Class]
+ confers_resistance_to_drug_class antibacterial free fatty acids [Drug Class]
+ confers_resistance_to_drug_class nucleoside antibiotic [Drug Class]
+ confers_resistance_to_drug_class lincosamide antibiotic [Drug Class]
+ confers_resistance_to_drug_class phenicol antibiotic [Drug Class]
+ confers_resistance_to_drug_class benzalkonium chloride [Drug Class]
+ confers_resistance_to_drug_class rhodamine [Drug Class]
+ confers_resistance_to_drug_class fosfomycin [Drug Class]
+ confers_resistance_to_drug_class bicyclomycin [Drug Class]
+ confers_resistance_to_drug_class isoniazid [Drug Class]
+ confers_resistance_to_drug_class rifamycin antibiotic [Drug Class]
+ confers_resistance_to_drug_class nitroimidazole antibiotic [Drug Class]
+ confers_resistance_to_drug_class oxazolidinone antibiotic [Drug Class]
+ confers_resistance_to_drug_class diaminopyrimidine antibiotic [Drug Class]
Sub-Term(s)
86 ontology terms | Show
Publications

Li XZ and Nikaido H. 2009. Drugs 69(12): 1555-1623. Efflux-mediated drug resistance in bacteria: an update. (PMID 19678712)

Pao SS, et al. 1998. Microbiol Mol Biol Rev 62(1): 1-34. Major facilitator superfamily. (PMID 9529885)

Saier MH Jr, et al. 1999. J Mol Microbiol Biotechnol 1(2): 257-279. The major facilitator superfamily. (PMID 10943556)