Corynebacterium striatum tetA

Accession ARO:3004639
DefinitiontetAB genes of the Corynebacterium striatum R-plasmid which encode an ABC transporter and confer tetracycline, oxytetracycline, and oxalic resistance
AMR Gene Familymajor facilitator superfamily (MFS) antibiotic efflux pump
Drug Classtetracycline antibiotic, cephalosporin, oxazolidinone antibiotic, rhodamine, acridine dye, penam, lincosamide antibiotic, phenicol antibiotic, rifamycin antibiotic, isoniazid, diaminopyrimidine antibiotic, macrolide antibiotic, nitroimidazole antibiotic, antibacterial free fatty acids, bicyclomycin, nucleoside antibiotic, fosfomycin, fluoroquinolone antibiotic, benzalkonium chloride, glycylcycline, peptide antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification30 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ confers_resistance_to_antibiotic tetracycline [Antibiotic]
+ confers_resistance_to_antibiotic oxacillin [Antibiotic]
+ major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic oxytetracycline [Antibiotic]
Publications

Tauch A, et al. 2000. Mol Gen Genet 263(1): 1-11. The 51,409-bp R-plasmid pTP10 from the multiresistant clinical isolate Corynebacterium striatum M82B is composed of DNA segments initially identified in soil bacteria and in plant, animal, and human pathogens. (PMID 10732668)

Resistomes

Prevalence of Corynebacterium striatum tetA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 900


>gb|NP_862226.1|+|Corynebacterium striatum tetA [Corynebacterium striatum]
MKTYSWFVPPAPPADDPARLHPARWSSGNRVVRDMVGAYPGVLVLHILSYLIGSGISAFVPVVVGMIVDGLVGEEKFNAWWLFAVLVGIF
IIQFIGEATGDGLATASVRRVTHNAQQHLSSGVLRRGAGAMSPGTVLNTIDADANTVGRYRELLSFPLMAIGYAVCAMVAMWSVSPWISL
AIPASALIIALFAAWTAGPVTRVSLKRRAAEADVAGLATDASQGIRTVKGLGAGATVATRFHAETAKANGLMLTHLRVEVWLGFARFCVA
WLCNLGIVGLSAWMTLRGEITPGQLTSVALLVQPALTMAGLAFGDLASGWGRAVASGQRIEQLHHAGDDAAGPEPTDTPVPGAGLWILEP
AERSYATAAAWAQRADVLFPPHTVNVFEGTIADNVNPRGDVPEDVVKQALAAAHCQDILRRLGGINEAGELPDAPLGEAGLNLSGGQRQR
VALARALAADPEVLILDDPTTGLDSVTQADVVAAVAALRADKTTVVITGNAAWQHAGTELEVA


>gb|NC_004939.1|+|4566-6107|Corynebacterium striatum tetA [Corynebacterium striatum]
ATGAAGACGTACAGCTGGTTCGTCCCGCCCGCGCCGCCAGCGGACGATCCGGCGCGGCTCCACCCAGCACGCTGGAGCAGCGGGAACCGT
GTGGTCAGGGACATGGTAGGCGCATACCCGGGCGTGCTAGTGCTGCACATTCTGAGCTACCTCATCGGCTCCGGCATCTCCGCGTTTGTG
CCGGTGGTGGTGGGCATGATCGTGGACGGCCTGGTGGGGGAAGAAAAGTTCAACGCATGGTGGCTCTTCGCAGTATTGGTCGGCATCTTC
ATCATCCAGTTCATCGGCGAGGCCACCGGCGACGGCCTGGCCACAGCCTCGGTGCGCCGCGTGACCCACAACGCGCAGCAGCACCTGTCC
TCGGGCGTGCTGCGCCGCGGGGCGGGAGCGATGAGCCCCGGCACCGTACTCAACACCATCGACGCGGACGCGAACACCGTCGGCCGCTAC
CGCGAGCTGCTGTCGTTTCCGCTCATGGCCATCGGCTACGCGGTCTGCGCGATGGTGGCGATGTGGTCGGTCTCCCCGTGGATCTCACTG
GCCATCCCGGCCAGCGCGCTGATCATCGCTCTGTTCGCCGCGTGGACCGCGGGGCCGGTGACGCGGGTGTCGTTGAAGCGTCGCGCCGCG
GAGGCGGATGTCGCTGGCTTGGCCACGGATGCGTCGCAAGGCATTCGCACCGTCAAAGGCCTAGGCGCGGGTGCAACCGTGGCAACACGT
TTTCACGCCGAAACGGCGAAGGCGAACGGCTTGATGCTCACGCACCTGCGTGTGGAGGTGTGGCTCGGTTTCGCCAGGTTTTGCGTGGCG
TGGCTGTGCAACCTTGGCATCGTGGGCTTGAGCGCGTGGATGACGCTGCGCGGGGAGATCACCCCGGGGCAGCTGACATCCGTGGCACTG
TTGGTGCAGCCTGCGTTGACCATGGCGGGCTTAGCGTTCGGCGACCTGGCCAGCGGGTGGGGCAGGGCCGTCGCGAGTGGCCAGCGCATC
GAGCAGCTGCACCACGCGGGCGATGACGCGGCGGGGCCTGAGCCGACAGACACCCCGGTCCCAGGCGCGGGGCTGTGGATTCTCGAGCCG
GCGGAGCGTTCCTACGCCACCGCCGCCGCGTGGGCGCAGCGCGCAGACGTGCTGTTCCCGCCGCACACCGTCAACGTGTTTGAGGGCACC
ATCGCAGACAACGTGAACCCGCGCGGGGATGTGCCGGAGGACGTCGTCAAGCAGGCGCTCGCCGCCGCCCACTGCCAAGACATCCTCCGC
AGGCTCGGCGGTATCAACGAAGCAGGCGAGTTGCCGGACGCGCCGCTGGGGGAGGCCGGCCTGAACCTTTCCGGCGGGCAGCGCCAGCGC
GTCGCGCTTGCCAGGGCGCTCGCCGCCGACCCGGAGGTGCTCATCCTGGACGACCCGACCACGGGGCTCGATTCCGTGACACAGGCGGAC
GTCGTGGCAGCCGTCGCCGCGCTCAGAGCAGACAAAACCACCGTGGTCATCACCGGAAACGCCGCGTGGCAGCACGCTGGAACCGAATTG
GAGGTGGCGTAG