oxacillin [Antibiotic]

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Accession ARO:0000056
Synonym(s)Oxacilline Prostaphlin Oxazocillin Prostaphlyn Oxacillinum Oxacilina Oxazocilline MPI-penicillin Ossacillina
DefinitionOxacillin is a penicillinase-resistant beta-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Oxacillin, especially in combination with other antibiotics, is effective against many penicillinase-producing strains of Staphylococcus aureus and Staphylococcus epidermidis.
Drug Classpenam
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ penam [Drug Class]
6 ontology terms | Show
+ beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic
+ MdtEF-TolC confers_resistance_to_antibiotic
+ Corynebacterium striatum tetA confers_resistance_to_antibiotic
+ blaS1 confers_resistance_to_antibiotic
+ mdeA confers_resistance_to_antibiotic
+ OXA beta-lactamase [AMR Gene Family] confers_resistance_to_antibiotic

Komatsuzawa H, et al. 1994. J Antimicrob Chemother 33(6): 1155-1163. Effect of combination of oxacillin and non-beta-lactam antibiotics on methicillin-resistant Staphylococcus aureus. (PMID 7928809)